First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX

Part of paid clinical trials in Anniston, Alabama.

Sponsor
AstraZeneca
Study ID
NCT00384176
Phase
PHASE2/PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 130 Years
Healthy Volunteers
Not accepted

Interventions

  • Cediranib — DRUG
    oral tablet once daily
  • Bevacizumab — DRUG
    intravenous infusion
  • 5-fluorouracil ( in FOLFOX) — DRUG
    intravenous infusion
  • Leucovorin (in FOLFOX) — DRUG
    intravenous infusion
  • Oxaliplatin (in FOLFOX) — DRUG
    intravenous infusion

Study Details

The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab) in combination with FOLFOX.

Key Dates

First listed
Oct 5, 2006
Start date
Aug 30, 2006
Status verified
Apr 2017
Primary completion
Nov 15, 2009
Completion
Aug 19, 2015

Study Design

Enrollment
1,814 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: 1
    Bevacizumab + FOLFOX
  • Experimental: 2
    Cediranib + FOLFOX

Primary Outcome Measure

Progression Free Survival [ Time Frame: Baseline then at Weeks 8, 16, 24 and then every 12 weeks until progression ]

Locations (44)

FacilityCityStateZIPSite coordinators
Research SiteAnnistonAlabama--
Research SiteBirminghamAlabama--
Research SiteCasa GrandeArizona--
Research SiteTucsonArizona--
Research SiteHot SpringsArkansas--
Research SitePalm SpringsCalifornia--
Research SiteSan DiegoCalifornia--
Research SiteFairfieldConnecticut--
Research SiteStamfordConnecticut--
Research SiteBay PinesFlorida--
Research SiteFort MeyersFlorida--
Research SitePort Saint LucieFlorida--
Research SiteGalesburgIllinois--
Research SitePark RidgeIllinois--
Research SiteQuincyIllinois--
Research SiteLayfayetteIndiana--
Research SiteNew AlbanyIndiana--
Research SiteAlexandriaLouisiana--
Research SiteLayfayetteLouisiana--
Research SiteHagerstownMaryland--
Research SiteAnn ArborMichigan--
Research SiteYpsilantiMichigan--
Research SiteSt LouisMissouri--
Research SiteGreat FallsMontana--
Research SiteLincolnNebraska--
Research SiteSummitNew Jersey--
Research SiteFresh MeadowsNew York--
Research SiteNorthportNew York--
Research SiteRochesterNew York--
Research SiteFayettevilleNorth Carolina--
Research SiteNew BernNorth Carolina--
Research SiteBismarckNorth Dakota--
Research SiteCincinnatiOhio--
Research SiteMiddletownOhio--
Research SiteZanesvilleOhio--
Research SiteCoos BayOregon--
Research SiteHilton Head IslandSouth Carolina--
Research SiteChattanoogaTennessee--
Research SiteKnoxvilleTennessee--
Research SiteNashvilleTennessee--
Research SiteAustinTexas--
Research SiteWhite River JunctionVermont--
Research SiteAbingdonVirginia--
Research SiteAlexandriaVirginia--

Find similar trials in Anniston, AL

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
Research Site· Anniston, ALResearch Site· Birmingham, ALResearch Site· Casa Grande, AZResearch Site· Tucson, AZResearch Site· Hot Springs, ARResearch Site· Palm Springs, CA

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