A Phase II Study of Bevacizumab + Sorafenib in Metastatic Breast Cancer

Part of paid clinical trials in Galesburg, Illinois.

Sponsor
Hoosier Cancer Research Network
Study ID
NCT00632541
Phase
PHASE2
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Sorafenib — DRUG
    Sorafenib 200mg po daily
  • Bevacizumab — DRUG
    Bevacizumab 5mg/kg every other week 1 Cycle = 4 weeks
  • Imaging — OTHER
    Imaging every third cycle

Study Details

Prior clinical trials involving bevacizumab and sorafenib have demonstrated single agent activity in previously treated advanced breast cancer. This trial will test combined VEGF inhibition with sorafenib and bevacizumab in less heavily pre-treated patients with advanced breast cancer.

Key Dates

First listed
Mar 10, 2008
Start date
Oct 31, 2007
Status verified
Feb 2018
Primary completion
Mar 31, 2009
Completion
Mar 31, 2009

Study Design

Enrollment
18 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Single Arm A
    Sorafenib 200mg po daily, Bevacizumab 5mg/kg every other week, 1 Cycle = 4 weeks. Imaging every third cycle

Primary Outcome Measure

Progression-Free Survival [ Time Frame: From the start of the treatment until the criteria for disease progression is met (or death occurs) maximum of 24 months ]

Locations (10)

FacilityCityStateZIPSite coordinators
Medical & Surgical Specialists, LLCGalesburgIllinois61401-
Oncology Hematology Associates of SW IndianaEvansvilleIndiana47714-
Fort Wayne Oncology & Hematology, IncFort WayneIndiana46815-
Indiana University Simon Cancer CenterIndianapolisIndiana46202-
Quality Cancer Center (MCGOP)IndianapolisIndiana46202-
Arnett Cancer CareLafayetteIndiana47904-
Horizon Oncology CenterLafayetteIndiana47905-
Medical Consultants, P.C.MuncieIndiana47303-
Northern Indiana Cancer Research ConsortiumSouth BendIndiana46601-
Ireland Cancer Center - University Hospitals of ClevelandClevelandOhio44106-

Find similar trials in Galesburg, IL

By condition
Breast cancer
By specialty
OncologyBreast oncologyWomen's health
By research site
Medical & Surgical Specialists, LLC· Galesburg, ILOncology Hematology Associates of SW Indiana· Evansville, INFort Wayne Oncology & Hematology, Inc· Fort Wayne, INIndiana University Simon Cancer Center· Indianapolis, INQuality Cancer Center (MCGOP)· Indianapolis, INArnett Cancer Care· Lafayette, IN

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