Randomized, Double-Blind Trial of Erlotinib/Pazopanib or Erlotinib/Placebo in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer

Part of paid clinical trials in Fort Myers, Florida.

Sponsor
SCRI Development Innovations, LLC
Study ID
NCT01027598
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Pazopanib — DRUG
    Pazopanib: 600 mg orally daily
  • Erlotinib — DRUG
    Erlotinib: 150 mg orally daily

Study Details

This randomized, placebo-controlled, Phase II trial will compare the combination of erlotinib with pazopanib (providing concurrent EGFR and VEGFR inhibition) with erlotinib alone in the second- or third-line treatment of patients with advanced NSCLC. This study will be conducted though the Sarah Cannon Research Consortium, a community-based clinical trial network.

Key Dates

First listed
Dec 8, 2009
Start date
Jan 31, 2010
Status verified
Dec 2015
Primary completion
Apr 30, 2014
Completion
Jun 30, 2014

Study Design

Enrollment
202 participants (actual)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Erlotinib + Pazopanib
    Erlotinib: 150 mg orally daily Pazopanib: 600 mg orally daily
  • Placebo Comparator: Erlotinib + Placebo
    Erlotinib: 150 mg orally daily Placebo: orally daily

Primary Outcome Measure

Progression-free Survival [ Time Frame: 14 months ]

Locations (8)

FacilityCityStateZIPSite coordinators
Florida Cancer SpecialistsFort MyersFlorida33901-
Suburban Hem OncLawrencevilleGeorgia30045-
Oncology Hematology CareCincinnatiOhio45242-
South Carolina Oncology Associates, PAColumbiaSouth Carolina29210-
Chattanooga Oncology Hematology AssociatesChattanoogaTennessee37404-
Family Cancer CenterCollervilleTennessee38119-
Tennessee Oncology, PLLCNashvilleTennessee37023-
Virginia Cancer InstituteRichmondVirginia23235-

Find similar trials in Fort Myers, FL

By condition
Lung cancer
By specialty
OncologyLung oncologyLung disease
By research site
Florida Cancer Specialists· Fort Myers, FLSuburban Hem Onc· Lawrenceville, GAOncology Hematology Care· Cincinnati, OHSouth Carolina Oncology Associates, PA· Columbia, SCChattanooga Oncology Hematology Associates· Chattanooga, TNFamily Cancer Center· Collerville, TN

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