Bevacizumab in Pats w/ Recurrent ST Brain Metas Who Have Failed Whole Brain Radiation Therapy

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT01898130
Phase
PHASE2
Status
Completed

Conditions

  • Metastatic Cancer
  • Unspecified Adult Solid Tumor, Protocol Specific

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • bevacizumab — BIOLOGICAL
    Given IV
  • quality-of-life assessment — PROCEDURE
    Ancillary studies

Study Details

This is a study to evaluate a drug called bevacizumab in patients with cancer whose disease has spread to their brain. This study will not evaluate the effect of bevacizumab on the systemic solid tumor cancer. Bevacizumab is a medication and it is thought that bevacizumab may interfere with the growth of new blood vessels; therefore it might stop tumor growth and possibly shrink the tumor by keeping it from receiving nutrients and oxygen supplied by the blood vessels.

Key Dates

First listed
Jul 12, 2013
Start date
Nov 27, 2013
Status verified
Mar 2019
Primary completion
Mar 23, 2017
Completion
Sep 5, 2018

Study Design

Enrollment
27 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Treatment (bevacizumab)
    Patients receive bevacizumab IV over 30-90 minutes every 2 weeks. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Primary Outcome Measure

Objective Radiographic Tumor Response in Patients With Recurrent Solid Tumor Brain Metastases Treated With Bevacizumab [ Time Frame: Every other cycle, starting cycle 3 (1 cycle =28 days) until off study. Range of cycles completed 1-20. ]

Locations (4)

FacilityCityStateZIPSite coordinators
Northwestern UniversityChicagoIllinois60611-
Northwestern Memorial Hospital: Lake Forest HospitalLake ForestIllinois60045-
Cadence Health - CDHWarrenvilleIllinois60555-
Columbia University Medical CenterNew YorkNew York10032-

Find similar trials in Chicago, IL

By research site
Northwestern University· Chicago, ILNorthwestern Memorial Hospital: Lake Forest Hospital· Lake Forest, ILCadence Health - CDH· Warrenville, ILColumbia University Medical Center· New York, NY

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