Optune® Plus Bevacizumab in Bevacizumab-Refractory Recurrent Glioblastoma

Part of paid clinical trials in La Jolla, California.

Sponsor
RTOG Foundation, Inc.
Study ID
NCT02743078
Phase
PHASE2
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
22 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bevacizumab — DRUG
    10 mg/kg every 2 weeks intravenously over 30 minutes.
  • TTFields Therapy — DEVICE
    Device is worn continuously at least 18 hours a day on average, with 1-3 days off every four weeks.

Study Details

This phase II trial will investigate the efficacy and safety of the addition of Optune (Tumor Treating Fields \[TTFields\] Therapy) to bevacizumab for patients with bevacizumab-refractory recurrent glioblastoma.

Key Dates

First listed
Apr 19, 2016
Start date
May 9, 2017
Status verified
Oct 2020
Primary completion
Oct 15, 2019
Completion
Oct 15, 2019

Study Design

Enrollment
3 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Bevacizumab and TTFields Therapy
    Bevacizumab starts on the first day (+/- 1 day) of Tumor Treating Fields (TTFields) therapy. Treatment is given until disease progression or the development of adverse events that require complete discontinuation.

Primary Outcome Measure

Overall Survival at 6 Months [ Time Frame: From registration to six months ]

Locations (11)

FacilityCityStateZIPSite coordinators
University of California, San DiegoLa JollaCalifornia92093-
University of California Irvine, Chao Family Comprehensive Cancer CenterOrangeCalifornia92868-
Miami Cancer Institute at Baptist HealthMiamiFlorida33176-
UF Health Cancer Center at Orlando HealthOrlandoFlorida32806-
Emory UniversityAtlantaGeorgia30322-
Washington University School of MedicineSt LouisMissouri63100-
University of RochesterRochesterNew York14642-
Cleveland Clinic FoundationClevelandOhio44195-
Thomas Jefferson UniversityPhiladelphiaPennsylvania19107-
Medical University of South CarolinaCharlestonSouth Carolina29425-
Medical College of WisconsinMilwaukeeWisconsin53226-

Find similar trials in La Jolla, CA

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By specialty
OncologyNeuro-oncology
By research site
University of California, San Diego· La Jolla, CAUniversity of California Irvine, Chao Family Comprehensive Cancer Center· Orange, CAMiami Cancer Institute at Baptist Health· Miami, FLUF Health Cancer Center at Orlando Health· Orlando, FLEmory University· Atlanta, GAWashington University School of Medicine· St Louis, MO

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