Brain cancer Clinical Trials

Recruiting brain cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat brain cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting brain cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting brain cancer trials

Within

Neurocognitive Assessment CNSL and LGG

for PCNSL

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07710131

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

for Brain Tumor

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 6 Months - 25

Code: NCT04085887·Phase 1, Phase 2

Apply to this trial

Asciminib With or Without Sildenafil for Brain Tumors

for Brain Tumor

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 39

Code: NCT07039760·EARLY_Phase 1

A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas

for Glioma

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18 - 65

Code: NCT04745156

B7-H3.CD28Z.CART in CNS Neoplasms

for Central Nervous System Neoplasms

2 sites in Boston

Sponsor: Robbie Majzner

Sex: All·Age: 2 - 21

Code: NCT07390539·Phase 1

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

for Meningioma

1 site in Nashville

Sponsor: Eben Rosenthal

Sex: All·Age: 18+

Code: NCT07493447·EARLY_Phase 1

Apply to this trial

Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

for Diffuse Intrinsic Pontine Glioma

6 sites incl. Los Angeles

Sponsor: BrainChild Bio, Inc

Sex: All·Age: 1 - 26

Code: NCT07680439·Phase 2

DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial)

for Neurosurgery

Sponsor: University of Malaya

Sex: All·Age: 18 - 65

Code: NCT07398066

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for Recurrent Glioblastoma

1 site in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 99

Code: NCT07416188·Phase 1, Phase 2

Apply to this trial

Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer

for Brain Tumor Adult

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07226466

Home-based Vision Rehabilitation Guided by Brain Imaging

for Visual Field Defect

1 site in Washington D.C.

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT07635329

Apply to this trial

Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being

for Brain Cancer

2 sites incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07628647

VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 Mutations

for Brain Cancer

1 site in Pittsburgh

Sponsor: Megan Mantica

Sex: All·Age: 18+

Code: NCT07629089·Phase 1

Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements

for Brain Tumor

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06630338

Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor

for Brain Tumor

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 18 - 75

Code: NCT07520370

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for Glioblastoma (GBM)

21 sites incl. Springdale

Sponsor: Black Diamond Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07326566·Phase 2

Apply to this trial

Precision Radiotherapy Enabled by Molecular MRI

for Brain Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07512154

Apply to this trial

Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain

for Brain Tumor

1 site in San Antonio

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18+

Code: NCT07470606·Phase 2

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

for Brain Cancer

1 site in Nashville

Sponsor: Eben Rosenthal

Sex: All·Age: 18+

Code: NCT07210632·EARLY_Phase 1

Apply to this trial

Safety and Effectiveness Evaluation of Temozolomide (Amitzo, NanoAlvand) in Patients With Grade III and IV Glioma Tumors

for Brain Tumor

Sponsor: NanoAlvand

Sex: All·Age: 18 - 80

Code: NCT07675070

Apply to this trial

A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 Gliomas

for Glioblastoma

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07003542·Phase 2

Apply to this trial

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

for Recurrent CNS Tumors

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 15 - 120

Code: NCT07374692

Apply to this trial

Home Transcranial Direct Current Stimulation (tDCS) to Enhance Functional Recovery

for Stroke

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07091396

Tumor Genomics, Individual Risk Factors, and External Drivers of Health on Health Outcomes for Patients With Meningioma

for Meningioma of Brain

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07418775

Apply to this trial

Measuring the Feasibility and Effect of a Virtual Reality Cognitive Training Intervention for Brain Cancer Survivors.

for Brain Cancer

1 site in Cincinnati

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT07313709

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

for Glioblastoma

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT06991101·Phase 2

Apply to this trial

C-SMART vs BE Well for Patients With Brain Tumors

for Brain Tumor

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT07224503

Apply to this trial

A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS

for Frozen Sections

Sponsor: VPIX Medical

Sex: All·Age: 18+

Code: NCT07254845·Phase 1

Feasibility of Mask-Free Radiotherapy for Brain Tumor Patients

for Brain Tumor

Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Sex: All·Age: 18+

Code: NCT07323966

Apply to this trial

HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)

for Brain Cancer

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT06930846

Apply to this trial

Visual Plasticity Following Brain Lesions

for Visual Field Defect

1 site in Washington D.C.

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT07105358

Apply to this trial

Head-to-Head Evaluation of the Cancer Ontology Supervised Multimodal Orchestration (COSMO) AI System Versus Pathologist-Only Review

for Brain Cancer

1 site in Boston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: All ages

Code: NCT07307157

Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.

for Frozen Sections

Sponsor: VPIX Medical

Sex: All·Age: 18+

Code: NCT06867978·Phase 1

Levetiracetam Prophylaxis in Brain Tumor Resection Pilot

for Seizures

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05897658·Phase 3

The Use of 5-ALA in Paediatric Patients With High Grade Brain Tumours

for Brain Tumor

Sponsor: University College, London

Sex: All·Age: 3 - 18

Code: NCT06678867·Phase 2

Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

15 sites incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2

Apply to this trial

Brodalumab in the Treatment of Immune-Related Adverse Events

for Breast Cancer

1 site in New York

Sponsor: Brian Henick, MD

Sex: All·Age: 18+

Code: NCT06673329·Phase 1

Apply to this trial

Brain Tumor Surgery and Postoperative Delirium

for Brain Tumor

Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Sex: All·Age: 18 - 80

Code: NCT06863064

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

for Glioblastoma

3 sites in Boston

Sponsor: Ugonma Chukwueke

Sex: All·Age: 18+

Code: NCT06552260·EARLY_Phase 1

Apply to this trial

MICRO-BRAIN 2024: Study on Pediatric Brain Tumors

for Brain Tumor

Sponsor: Meyer Children's Hospital IRCCS

Sex: All·Age: 3 - 18·Accepts healthy volunteers

Code: NCT07417085

Apply to this trial

A Study of Sotorasib in People With Brain Tumors

for Brain Tumor

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06807619·Phase 1

Apply to this trial

Tracing Brain Tumors Through Deep Time

for Brain Tumor

Sponsor: Tata Memorial Centre

Sex: All·Age: All ages

Code: NCT06381531

Apply to this trial

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

for Breast Cancer

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT06580002·Phase 2

Apply to this trial

A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients

for Glioblastoma Multiforme

Sponsor: NaviFUS Corporation

Sex: All·Age: 18 - 80

Code: NCT06496971·Phase 3

Apply to this trial

Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM)

for Glioblastoma Multiforme

1 site in Charlottesville

Sponsor: NaviFUS Corporation

Sex: All·Age: 18+

Code: NCT06329570·Phase 1, Phase 2

Apply to this trial

TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas

for Brain Tumor

Sponsor: Essen Biotech

Sex: All·Age: 16 - 90

Code: NCT06640582·Phase 1, Phase 2

Apply to this trial

Development of MRF for Characterization of Brain Tumors After Radiotherapy

for Brain Tumor

2 sites in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06101069

Apply to this trial

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

for Brain Metastases

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT06048094·Phase 1

Apply to this trial

The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies

for Brain Tumor

Sponsor: Stephen Lownie

Sex: All·Age: 18 - 80

Code: NCT06229483·Phase 3

Apply to this trial

Genetic and Molecular Characterization of Nervous System Lesions

for Brain Tumor

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT06314607

Apply to this trial

Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy

for Cognitive Impairment

Sponsor: Region Stockholm

Sex: All·Age: 5+

Code: NCT06051240·Phase 2

Apply to this trial

Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

for Brain Tumor

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05733312

Apply to this trial

CONVIVO Endomicroscopy

for Brain Tumor

1 site in Manhasset

Sponsor: Northwell Health

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06087393

Apply to this trial

Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders

for Autism Spectrum Disorder

2 sites incl. Phoenix

Sponsor: Southwest Autism Research & Resource Center

Sex: All·Age: Up to 18·Accepts healthy volunteers

Code: NCT04322734

Apply to this trial

Biological Collection of Brain Tumors

for Brain Tumor

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT05571579

Apply to this trial

Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)

for Carotid Artery Stenosis

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 18 - 80

Code: NCT05968053

Apply to this trial

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

for Brain Cancer

1 site in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06058988·Phase 2

Apply to this trial

European Prospective Investigation Into Childhood Cancer

for Acute Lymphoblastic Leukemia

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 3 - 21

Code: NCT05375617

Apply to this trial

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

for Glioma, Malignant

1 site in New York

Sponsor: Northwell Health

Sex: All·Age: 18+

Code: NCT05954858

Apply to this trial

Cognitive Training in the Virtual Reality Setting With Children Undergoing Radiotherapy for Brain Tumors

for Brain Tumor

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 8 - 22

Code: NCT05947045

Apply to this trial

Brain cancer clinical trials — common questions

Are brain cancer clinical trials free to join?

Yes. Participating in a brain cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a brain cancer clinical trial?

Each brain cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a brain cancer trial near me?

Use the location controls above. We'll show recruiting brain cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many brain cancer trials are recruiting right now?

We're currently tracking roughly 70 recruiting brain cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Brain cancer trials by city

Boston, MA Miami, FL San Francisco, CA Cincinnati, OH Cleveland, OH Los Angeles, CA Aurora, CO Detroit, MI Duarte, CA Jacksonville, FL Milwaukee, WI Orange, CA

Related specialties

Oncology Neuro-oncology