Neuro-oncology Clinical Trials

Recruiting neuro-oncology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat neuro-oncology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting neuro-oncology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting neuro-oncology trials

Within

Safety and Efficacy Study of Safusidenib in Participants With IDH1-Mutant Glioma Who Discontinued Vorasidenib Treatment Due to Progressive Disease

for Grade 2 IDH1-mutant Glioma

Sponsor: Nuvation Bio Inc.

Sex: All·Age: 18+

Code: NCT07703436·Phase 2

Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG

for High Grade Glioma

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 - 39

Code: NCT07644312·Phase 2

Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform

for Glioblastoma Multiforme

Sponsor: Olympion Medical Center

Sex: All·Age: 18+

Code: NCT01777919·Phase 2

CM93 Treatment in Subjects With Epidermal Growth Factor Receptor (EGFR)-Modified Recurrent Glioblastoma (rGBM)

for Glioblastoma

Sponsor: Crimson Biopharm Inc.

Sex: All·Age: 18+

Code: NCT04933422·Phase 1

NG101m Adjuvant Therapy in Glioblastoma Patients

for Glioblastoma Multiforme

1 site in Houston

Sponsor: NeuGATE Theranostics

Sex: All·Age: 18+

Code: NCT04373785·Phase 1, Phase 2

ctDNA-Guided Intraventricular Therapy for CNS Malignancies

for Leptomeningeal Disease

Sponsor: Alireza Mansouri

Sex: All·Age: 18 - 120

Code: NCT07689721

PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

for Glioblastoma

1 site in Los Angeles

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06448286·Phase 3

A Study for Cerebral Open Flow Microperfusion

for Glioma

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07089758

Pilot Radioembolisation Clinical Trial Assessing Safety and Efficacy in Recurrent Glioma

for Recurrent Glioblastoma IDH Wildtype

Sponsor: Olivia Newton-John Cancer Research Institute

Sex: All·Age: 18+

Code: NCT07712770·EARLY_Phase 1

A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent Glioblastoma

for Phase 1

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07579208·Phase 1

Clinical Benefit of 18F-FET in Glioma.

for Glioma

Sponsor: Primo Biotechnology Co., Ltd

Sex: All·Age: 20+·Accepts healthy volunteers

Code: NCT07698457·Phase 3

Monitoring of Neurological Symptoms, Treatment Tolerance, and Quality of Life Using the Resilience PRO Electronic Patient-reported Outcome Application in Patients With IDH-mutated Glioma

for Oncology

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07439302

Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed Glioblastoma

for Glioblastoma

Sponsor: Beijing Tricision Biotherapeutics Inc

Sex: All·Age: 18 - 70

Code: NCT07715097·Phase 2

Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-up

for Glioblastoma

Sponsor: Centre Paul Strauss

Sex: All·Age: 18+

Code: NCT07628257

A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma

for Glioblastoma

1 site in Chicago

Sponsor: Catalina Lee Chang

Sex: All·Age: 18+

Code: NCT07422896·Phase 1

Movie-Watching Functional MRI for Mapping Brain Function in Neurosurgical Patients

for Glioma

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 70

Code: NCT07650994

Neurocognitive Assessment CNSL and LGG

for PCNSL

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07710131

Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures

for Brain Tumor

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 6 Months - 25

Code: NCT04085887·Phase 1, Phase 2

Apply to this trial

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

for Newly Diagnosed Glioblastoma

1 site in Durham

Sponsor: Mustafa Khasraw, MBChB, MD, FRCP, FRACP

Sex: All·Age: 18+

Code: NCT04903795·Phase 1

Asciminib With or Without Sildenafil for Brain Tumors

for Brain Tumor

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18 - 39

Code: NCT07039760·EARLY_Phase 1

Language Network Prehab Via fMRI Neurofeedback

for Glioma

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07488780

Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent Glioblastomas

for Glioblastoma

2 sites incl. Rochester

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07620548·Phase 2

A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas

for Glioma

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18 - 65

Code: NCT04745156

MeDex: No Perioperative Dexamethasone in Brain Metastases

for Brain Metastases

1 site in Louisville

Sponsor: University of Louisville

Sex: All·Age: 18+

Code: NCT07044557

Apply to this trial

EEG-Guided Cognitive Function Preservation in Patients With Brain Tumors

for Glioma

Sponsor: Bo Wang

Sex: All·Age: 18 - 75

Code: NCT07699172

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

for Brain Metastases

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07248228·Phase 2

Apply to this trial

B7-H3.CD28Z.CART in CNS Neoplasms

for Central Nervous System Neoplasms

2 sites in Boston

Sponsor: Robbie Majzner

Sex: All·Age: 2 - 21

Code: NCT07390539·Phase 1

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

for Meningioma

1 site in Nashville

Sponsor: Eben Rosenthal

Sex: All·Age: 18+

Code: NCT07493447·EARLY_Phase 1

Apply to this trial

IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases

for Brain Metastases

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 80

Code: NCT07569263·Phase 1

A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma

for Glioblastoma

3 sites incl. Phoenix

Sponsor: Myosin Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07604285·Phase 1, Phase 2

Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG).

for Diffuse Intrinsic Pontine Glioma

6 sites incl. Los Angeles

Sponsor: BrainChild Bio, Inc

Sex: All·Age: 1 - 26

Code: NCT07680439·Phase 2

Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG

for Glioma

1 site in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 - 21

Code: NCT05555550·EARLY_Phase 1

Apply to this trial

DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial)

for Neurosurgery

Sponsor: University of Malaya

Sex: All·Age: 18 - 65

Code: NCT07398066

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

for Recurrent Glioblastoma

1 site in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 99

Code: NCT07416188·Phase 1, Phase 2

Apply to this trial

AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors

for Pediatric Brain Tumors

Sponsor: Huashan Hospital

Sex: All·Age: 0 - 17

Code: NCT07703605

A Clinical Trial Evaluating the Tolerability, Safety, and Preliminary Efficacy of NRG-103 Injection in Patients With Recurrent or Progressive High-grade Glioma

for HGG

Sponsor: Neuregen Therapeutics Co., Ltd.

Sex: All·Age: 18+

Code: NCT07710690·Phase 1

Apply to this trial

Phase I Trial of pH Resections of GBM at VA

for Glioblastoma

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07218367·Phase 1

Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer

for Brain Tumor Adult

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07226466

Home-based Vision Rehabilitation Guided by Brain Imaging

for Visual Field Defect

1 site in Washington D.C.

Sponsor: Georgetown University

Sex: All·Age: 18+

Code: NCT07635329

Apply to this trial

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

for Breast Cancer

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: Female·Age: 18+

Code: NCT07454668·Phase 1

Oral Gallium Maltolate for Recurrent Glioblastoma

for Glioblastoma

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT07515924·EARLY_Phase 1

Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being

for Brain Cancer

2 sites incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07628647

VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 Mutations

for Brain Cancer

1 site in Pittsburgh

Sponsor: Megan Mantica

Sex: All·Age: 18+

Code: NCT07629089·Phase 1

Evaluation of [⁶⁸Ga/¹⁷⁷Lu]HT547: Safety, Biodistribution, and Dosimetry in Solid Tumors

for Breast Cancer

Sponsor: Hua Pang

Sex: All·Age: 18 - 90

Code: NCT07639970·EARLY_Phase 1

Exploratory Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Tumor Neoantigen-pulsed Autologous Dendritic Cell Injection (YS247, Beijing YSCell Biotech Co., Ltd. [Abbreviated as YS])in Patients With Recurrent or Progressive Glioblastoma

for Glioblastoma

Sponsor: Huanhu Hospital Affiliated to Tianjin Medical University

Sex: All·Age: 18 - 75

Code: NCT07678138

A Study of HF1K16 Combined With Bevacizumab in Patients With Recurrent or Progressive Glioma

for Glioma

Sponsor: HighField Biopharmaceuticals Corporation

Sex: All·Age: 18 - 75

Code: NCT07678684·Phase 2

Apply to this trial

Vortioxetine for Newly Diagnosed Glioblastoma

for Glioblastoma

Sponsor: University of Zurich

Sex: All·Age: 18+

Code: NCT07284628·Phase 2

Apply to this trial

Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent Glioblastoma

for Recurrent Glioblastoma (WHO-Grade IV Glioma)

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 18 - 80

Code: NCT07648823·EARLY_Phase 1

Apply to this trial

Imaging Acetadote Metabolism in Glioblastoma

for Glioblastoma

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT07387666·EARLY_Phase 1

Apply to this trial

Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent Glioblastoma

for Glioblastoma

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07392957·Phase 1, Phase 2

Apply to this trial

Impact of Fluorescence-Guided Resection and Chemoradiotherapy on the Systemic Immune Response in Glioblastoma: A Kinetic Analysis of Immune Biomarkers.

for Glioblastoma

Sponsor: University Hospital, Lille

Sex: All·Age: 18+

Code: NCT07568782

Sitagliptin in Recurrent/Progressive Grade 4 Glioma

for Glioma

1 site in Iowa City

Sponsor: Kailin Yang, MD, PhD

Sex: All·Age: 18+

Code: NCT07541781·Phase 1

Apply to this trial

Using the Epitranscriptome to Diagnose and Treat Gliomas

for Glioma

Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06575452

Apply to this trial

Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements

for Brain Tumor

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06630338

Pharmacoscopy for Patients With Refractory Primary Brain Tumors

for Brain (Nervous System) Cancers

Sponsor: University of Zurich

Sex: All·Age: 18+

Code: NCT06804655·Phase 2

Pilot Study of Navigated Focused Ultrasound and Pembrolizumab in the Treatment of Recurrent WHO Grade 4 IDH-Wildtype Glioblastoma With Mismatch Repair Deficiency

for Glioblastoma

1 site in Cincinnati

Sponsor: Jennifer Leddon

Sex: All·Age: 18+

Code: NCT07385846·Phase 1

Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain Tumor

for Brain Tumor

Sponsor: Beijing Tiantan Hospital

Sex: All·Age: 18 - 75

Code: NCT07520370

Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases

for Breast Cancer

Sponsor: Nanfang Hospital, Southern Medical University

Sex: Female·Age: 18 - 75

Code: NCT07539753·Phase 2

Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)

for High Grade Glioma (HGG) of the Brain With BRAF Aberration

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT07206849·Phase 2

MRinRT: Swansea University and SWWCC Collaboration Study.

for Carcinoma

Sponsor: Swansea Bay University Health Board

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07365124

Neuro-oncology clinical trials — common questions

Are neuro-oncology clinical trials free to join?

Yes. Participating in a neuro-oncology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a neuro-oncology clinical trial?

Each neuro-oncology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a neuro-oncology trial near me?

Use the location controls above. We'll show recruiting neuro-oncology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many neuro-oncology trials are recruiting right now?

We're currently tracking roughly 370 recruiting neuro-oncology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Neuro-oncology trials by city

San Francisco, CA Boston, MA Los Angeles, CA Miami, FL Aurora, CO Birmingham, AL Cleveland, OH Cincinnati, OH Gainesville, FL Chicago, IL Columbus, OH Duarte, CA

Conditions in this area

Glioblastoma Glioma Brain cancer Brain metastases