Investigating Cabozantinib in Patients With Refractory Metastatic Colorectal Cancer

Part of paid clinical trials in Tucson, Arizona.

Sponsor
Academic Thoracic Oncology Medical Investigators Consortium
Study ID
NCT03542877
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • Oral Tablet: Cabozantinib — DRUG
    Patients will take 60mg cabozantinib, by mouth, once daily, every day for 12 weeks. This medication should be taken on an empty stomach. Patients should not eat 2 hours before or 1 hour after taking cabozantinib. Only water is permitted during this 3 hour time frame.

Study Details

This study seeks to use Cabozantinib to treat those with Metastatic Colorectal Cancer who have not previously responded to treatment.

Key Dates

Start date
Jun 1, 2018
Status verified
Jun 2022
Primary completion
Oct 19, 2020
Completion
Mar 7, 2022

Study Design

Enrollment
44 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Oral Cabozantinib
    Patients will be enrolled to take 60mg of cabozantinib, by mouth, once a day, every day, for 12 weeks. If less than three patients have Progression Free Survival (PFS) lasting at least 12 weeks, the study will be terminated.

Primary Outcome Measure

12-Week Progression Free Survival [ Time Frame: This outcome was assessed at the 12-week assessment. Subjects without the 12-week assessment but who had at least 11 weeks of treatment were included. ]

Locations (10)

FacilityCityStateZIPSite coordinators
University of ArizonaTucsonArizona85724-
Kenneth Norris Jr. Comprehensive Cancer CenterLos AngelesCalifornia90033-
Universtiy of Colorado DenverAuroraColorado80045-
Lone Tree Health CenterLone TreeColorado80124-
Massachusetts General Hospital Cancer CenterBostonMassachusetts02114-
Rutgers Cancer Institute of New JerseyNew BrunswickNew Jersey08903-
Jefferson Abington HospitalAbingtonPennsylvania19001-
Fox Chase Cancer CenterPhiladelphiaPennsylvania19111-
Thomas Jefferson UniversityPhiladelphiaPennsylvania19107-
Swedish Medical CenterSeattleWashington98122-

Find similar trials in Tucson, AZ

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
University of Arizona· Tucson, AZKenneth Norris Jr. Comprehensive Cancer Center· Los Angeles, CAUniverstiy of Colorado Denver· Aurora, COLone Tree Health Center· Lone Tree, COMassachusetts General Hospital Cancer Center· Boston, MARutgers Cancer Institute of New Jersey· New Brunswick, NJ

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