PAlliative RAdioTherapy to Lung Cancer A Randomized Multicentre Phase III Study

Sponsor
University of Aarhus
Study ID
NCT03632603
Phase
PHASE3
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • No intervention — RADIATION
    No intervention during study period.

Study Details

The aim of this study is to examine if a shorter palliative radiotherapy fractionation scheme of 20 Gy / 4 F can reduce the early oesophageal toxicity compared to 30 Gy / 10 F in patients with lung cancer in performance status (PS) 0-2. Secondary aims are to examine the effect on lung cancer symptoms, quality of life (QoL) and survival. Furthermore, the investigators aim at standardizing the quality of palliative thoracic radiotherapy in all Danish centres at the highest technical level.

Key Dates

Start date
Nov 22, 2018
Status verified
May 2024
Primary completion
Aug 31, 2025
Completion
Aug 31, 2025

Study Design

Enrollment
1,184 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Radiotherapy 20 Gy / 4 F
    Radiotherapy 20 Gy / 4 F
  • Active Comparator: Radiotherapy 30 Gy/ 10 F
    Radiotherapy 30 Gy/ 10 F

Primary Outcome Measure

Early oesophagitis [ Time Frame: 2 weeks after completion of radiotherapy ]

Central Contacts

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