A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT04118374
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Standard Carb Diet — OTHER
    Approximately 50% of caloric intake will come from carbohydrate consumption.
  • Low Carb Diet — OTHER
    Approximately 25% of caloric intake will come from carbohydrate consumption.

Study Details

The investigators will test the hypothesis that reducing insulin doses using a low carbohydrate diet (LCD) will be associated with with improved insulin sensitivity (Aim 1) and blood vessel health (Aim 2).

Key Dates

Start date
Nov 24, 2021
Status verified
Sep 2025
Primary completion
Jun 21, 2024
Completion
Jun 21, 2024

Study Design

Enrollment
14 participants (actual)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Standard Carb Diet then Low Carb Diet
  • Experimental: Low Carb Diet then Standard Carb Diet

Primary Outcome Measure

Change in Insulin Sensitivity Assessed as Glucose Infusion Rates [ Time Frame: week 1 and week 5 ]

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37232-

Find similar trials in Nashville, TN

By condition
Type 1 diabetes
By specialty
Endocrinology
By research site
Vanderbilt University Medical Center· Nashville, TN

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