Pathogenic Study of Adult Immune Enteropathies

Conditions

• Autoimmune Enteropathy
• Celiac Disease
• Inflammatory Bowel Diseases

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Blood sample collection; gastrointestinal biopsy — GENETIC
  Targeted Next generation sequencing and whole exome sequencing Phenotyping of intestinal lymphocytes, single cell analyses, cytokines dosage...

Study Details

The study focuses the mechanisms underlying the loss of intestinal homeostasis in celiac disease, refractory celiac disease and other immune diseases such as monogenic enteropathy, inflammatory bowel diseases or drug induced intestinal diseases. Mechanisms of transformation of lymphocytes leading to onset of lymphomatous complications of immune enteropathies will be investigated. Mechanisms of loss of hepatic lymphocytic homeostasis will also be assessed in liver associated diseases.

Key Dates

First listed

Feb 21, 2020

Start date

Feb 27, 2020

Status verified

Sep 2025

Primary completion

Feb 27, 2030

Completion

Feb 27, 2033

Study Design

Enrollment

200 participants (estimated)

Arms

• Arm: Active coeliac patients
  Patients with active coeliac disease
• Arm: Treated coeliac patients
  Patients with coeliac disease on gluten free diet
• Arm: Sprue type I
  Patients with refractory coeliac disease of type I
• Arm: Sprue type II
  Patients with refractory coeliac disease of type II
• Arm: Intestinal Lymphoproliferations
  Patients with intestinal lymphoproliferations
• Arm: Non coeliac enteropathies
  Patients with non coeliac immune-mediated enteropathy
• Arm: Patients without neoplastic or inflammatory intestinal disease
  Patients without neoplastic or inflammatory intestinal disease

Primary Outcome Measure

Intestinal Lymphocytes count [ Time Frame: Baseline ]

Central Contacts

• Georgia MALAMUT, MD, PhD
  33 1 58 41 41 76
  [email protected]
• Anaïs LEVESCOT, MD, PhD
  33 1 42 75 42 77
  [email protected]

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