Autoimmune disease Clinical Trials

Recruiting autoimmune disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat autoimmune disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting autoimmune disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting autoimmune disease trials

Within

Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients

for Atopic Dermatitis

1 site in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 6+

Code: NCT06397781·Phase 4

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease

for Crohn's Disease

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06510296

Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 5 - 17

Code: NCT05976802·Phase 4

Exercise With and Without Cognitive Training

for Multiple Sclerosis

1 site in Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: 55 - 85

Code: NCT07447115

Apremilast and Adalimumab in Psoriatic Arthritis Patients

for Psoriatic Arthritis

Sponsor: Tanta University

Sex: All·Age: 18 - 70

Code: NCT07398651

Lead Exposure and Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07423312

Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Baylx Inc.

Sex: All·Age: 18 - 70

Code: NCT03828344·Phase 1

Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tianjin Medical University General Hospital

Sex: All·Age: 18 - 60

Code: NCT06228781

Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care

for Multiple Sclerosis

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT06386133

Ex Vivo Study of hAMSC Secretome in Inflammatory Bowel Disease: Effects on Inflammation and Fibrosis (TARGET)

for Inflammatory Bowel Diseases

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07721207

A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus

for Multiple Sclerosis

Sponsor: Polpharma Biologics International AG

Sex: All·Age: 18 - 65

Code: NCT07606521·Phase 1

Study to Characterise Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Anifrolumab Administered Subcutaneously (SC) or Intravenously (IV)

for Systemic Lupus Erythematosus

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT07688980·Phase 1

A Study of Early Secukinumab Treatment in Moderate to Severe Hidradenitis Suppurativa Patients

for Hidradenitis Suppurativa

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07690319

Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease

for Crohn Disease

Sponsor: Nantes University Hospital

Sex: All·Age: 18 - 70

Code: NCT05584228

Saphnelo Use in Females of Child-bearing Potential

for Systemic Lupus Erythematosus

Sponsor: AstraZeneca

Sex: Female·Age: 15 - 50

Code: NCT07431775

Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hunter College of City University of New York

Sex: All·Age: 18+

Code: NCT07552428

Evaluation of Serum IL-41 Level in Patients With Ankylosing Spondylitis and Psoriatic Arthritis

for Ankylosing Spondylitis

Sponsor: Assiut University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07648836

A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in Dermatology

for Chronic Dermatological Conditions

Sponsor: National University Hospital, Singapore

Sex: All·Age: 16+

Code: NCT07481019

A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body

for Rheumatoid Arthritis

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07649265·Phase 1

Safety and Efficacy of ONT01 in Lupus

for Lupus Nephritis (LN)

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT07107659·EARLY_Phase 1

Apply to this trial

OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis

for Multiple Sclerosis

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 65

Code: NCT07221799·Phase 1

Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project

for Multiple Sclerosis

1 site in Boca Raton

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT07472413·Phase 3

Multicenter Prospective Study Analyzing the Occurrence of Multiple Sclerosis Relapses Without Radiological Evidence: Myth or Reality?

for Multiple Sclerosis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18 - 70

Code: NCT07545889

Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Sharjah

Sex: All·Age: 18+

Code: NCT07555379

My MS Toolkit: An Internet-Based Depression Self-Management Program for Adults Living With Multiple Sclerosis

for Multiple Sclerosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07636434

Nailfold Capillaroscopic Changes in Psoriasis

for Psoriasis

Sponsor: Al-Azhar University

Sex: All·Age: All ages

Code: NCT07693595

Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool

for Optic Neuritis

Sponsor: King's College London

Sex: All·Age: 16+

Code: NCT07704294

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in Children With Generalized Myasthenia Gravis (gMG)

for Generalized Myasthenia Gravis

1 site in Austin

Sponsor: Amgen

Sex: All·Age: 2 - 17

Code: NCT06987539·Phase 2

Apply to this trial

Emerging Indications for Hyperbaric Oxygen Treatment

for Post-COVID-19 Condition

Sponsor: Jay C. Buckey Jr.

Sex: All·Age: All ages

Code: NCT07240649·Phase 4

The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health

for Preterm Birth

Sponsor: GrowBaby Life Project

Sex: Female·Age: 18+

Code: NCT07559773

Opzelura Experience Study

for Atopic Dermatitis

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 2+

Code: NCT07661979·Phase 4

Treatment of Chinese Adult Subjects With Moderate to Severe Crohn's Disease With Tabellvi®

for Crohn's Disease

Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Sex: All·Age: 18 - 70

Code: NCT07663526·Phase 4

Online Pain Education for Crohn's Disease and Ulcerative Colitis

for Crohn's Disease

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT07671313

Inspiratory Muscle Training in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18 - 65

Code: NCT07672535

Efficacy and Tolerability of a Probiotic Ointment

for Atopic Dermatitis

Sponsor: BioGaia AB

Sex: All·Age: 6 Months - 15

Code: NCT07701447

Personalized Approach to Celiac Disease Diagnosis

for Celiac Disease

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07701655

FES: Effect on Walking in the Real World and Participation in Daily Life in People With Multiple Sclerosis.

for Multiple Sclerosis

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 22 - 75

Code: NCT07706114

A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy

for Multiple Sclerosis

10 sites incl. Birmingham

Sponsor: Genentech, Inc.

Sex: All·Age: 18 - 65

Code: NCT07609719·Phase 4

Combined Fractional CO₂ Laser and Topical Corticosteroid Versus Topical Corticosteroid Only in the Treatment of Palmoplantar Psoriasis

for Psoriasis

Sponsor: Cairo University

Sex: All·Age: 18 - 60

Code: NCT07713212·Phase 4

Simultaneous T2-FLAIR and T1 Brain MRI With ENRAGED FLAIR in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Region Stockholm

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07687693

Xylitol Use for Decolonization of C. Difficile in Patients With IBD

for Inflammatory Bowel Diseases

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05852587·Phase 1

Efficacy and Safety of CDED With Anti-TNF-α Biologics in Crohn's Disease

for Crohn Disease

Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07344428

Utilization of a Microdevice for Psoriasis and Atopic Dermatitis

for Psoriasis

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07352566·Phase 4

Augmented Reality-Based Dual-Task Training in People With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Sharjah

Sex: All·Age: 18+

Code: NCT07434934

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

for Multiple Sclerosis

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 64

Code: NCT07475377

Microbiome-targeted Diet Therapy in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07520461

Retrospective Observational Multicenter Study on the Treatment Patterns, Extra-Intestinal Manifestations, Resource Utilisation, and Outcomes of Patients With Inflammatory Bowel Disease in Dutch Hospitals

for Crohn Disease

Sponsor: LOGEX

Sex: All·Age: 18+

Code: NCT07682038

Azithromycin in Atopic Dermatitis

for Atopic Dermatitis

Sponsor: Cairo University

Sex: All·Age: 3 - 12

Code: NCT07713186·Phase 4

US Zamto-cel Autoimmune Diseases

for Lupus Nephritis

1 site in Milwaukee

Sponsor: Miltenyi Biomedicine GmbH

Sex: All·Age: 18+

Code: NCT06708845·Phase 1

Apply to this trial

Assessing Psoriasis Treatment Outcomes

for Psoriasis

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07391423

A Real-world Study of Patients With Hidradenitis Suppurativa and High Cardiovascular Risk or Established Coronary Plaque Treated With Secukinumab

for Hidradenitis Suppurativa

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT07454889

Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07456566

Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation

for Ulcerative Colitis

1 site in Ann Arbor

Sponsor: Muhammad N Aslam, MD

Sex: All·Age: 5 - 80

Code: NCT07501078·Phase 2

Apply to this trial

An Online Nurse-Led Purpose-Focused Group Program for Adult Women With Multiple Sclerosis: Effects on Meaning and Quality of Life

for Multiple Sclerosis

1 site in Denton

Sponsor: Texas Woman's University

Sex: Female·Age: 18+

Code: NCT07555015

Apply to this trial

The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hacettepe University

Sex: All·Age: 18+

Code: NCT07578740

RD06-05 Universal CD19/BCMA CAR-T for Refractory Pediatric Autoimmune Diseases

for Autoimmune Diseases

Sponsor: The Children's Hospital of Zhejiang University School of Medicine

Sex: All·Age: 5 - 20

Code: NCT07674147·EARLY_Phase 1

A Study of C-CAR168 in the Treatment of Autoimmune Diseases Refractory to Standard Therapy

for Multiple Sclerosis (MS)

Sponsor: The Affiliated Hospital of Qingdao University

Sex: All·Age: 18 - 70

Code: NCT07676266·Phase 1

A Clinical Study of HRS-8797 in Healthy Participants

for Atopic Dermatitis

Sponsor: Chengdu Suncadia Medicine Co., Ltd.

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07698756·Phase 1

Efficacy and Safety of Ravulizumab in Chinese Adults Participants With Generalized Myasthenia Gravis (gMG)

for Generalized Myasthenia Gravis

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 130

Code: NCT07596784·Phase 3

Autoimmune disease clinical trials — common questions

Are autoimmune disease clinical trials free to join?

Yes. Participating in a autoimmune disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a autoimmune disease clinical trial?

Each autoimmune disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a autoimmune disease trial near me?

Use the location controls above. We'll show recruiting autoimmune disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many autoimmune disease trials are recruiting right now?

We're currently tracking roughly 663 recruiting autoimmune disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Autoimmune disease trials by city

Birmingham, AL Boston, MA Chicago, IL San Francisco, CA Los Angeles, CA Aurora, CO Ann Arbor, MI La Jolla, CA Seattle, WA Sacramento, CA Miami, FL Orange, CA

Conditions in this area

Rheumatoid arthritis Psoriatic arthritis Lupus (SLE)Psoriasis Atopic dermatitis / eczema Hidradenitis suppurativa Autoimmune diseases (general)Multiple sclerosis Crohn's disease Ulcerative colitis Inflammatory bowel disease (IBD)Myasthenia gravis Celiac disease