Autoimmune disease Clinical Trials

Recruiting autoimmune disease studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat autoimmune disease. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting autoimmune disease studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting autoimmune disease trials

Within

Effect of S. Aureus Skin Decolonization on Disease Severity in Atopic Dermatitis Patients

for Atopic Dermatitis

1 site in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 6+

Code: NCT06397781·Phase 4

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease

for Crohn's Disease

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06510296

Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 5 - 17

Code: NCT05976802·Phase 4

Autoimmune Disease Treatment With Mesenchymal Stem Cells (MSCs) and CAR-T Cells

for Autoimmune Diseases

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 18 - 75

Code: NCT06435897·Phase 1, Phase 2

CAR-T Cells Targeting Autoimmune Diseases

for Autoimmune Diseases

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 18 - 75

Code: NCT05459870·Phase 1, Phase 2

Determine the Dose-dependent Efficacy and Safety of EC-18 in Patients With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

Sponsor: Enzychem Lifesciences Corporation

Sex: All·Age: 19 - 79

Code: NCT06487000·Phase 2

LMT503 First-in-human SAD, MAD, and FE Study

for Inflammatory Bowel Disease

Sponsor: Lmito Therapeutics Inc.

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05659953·Phase 1

Exercise With and Without Cognitive Training

for Multiple Sclerosis

1 site in Decatur

Sponsor: VA Office of Research and Development

Sex: All·Age: 55 - 85

Code: NCT07447115

Safety and Preliminary Efficacy of HN2302 in Patients With Autoimmune Diseases

for Autoimmune Disease

Sponsor: Shenzhen MagicRNA Biotechnology Co., Ltd

Sex: All·Age: 18 - 69

Code: NCT07523282·Phase 1

Efficacy and Safety of HN2301 in Patients With Generalized Myasthenia Gravis (MG)

for Generalized Myasthenia Gravis

Sponsor: Shenzhen MagicRNA Biotechnology Co., Ltd

Sex: All·Age: 18 - 80

Code: NCT07556120·Phase 1

MIRICURE: Mirikizumab With Curettage and Repair (Closure) for Perianal Fistulizing Crohn's Disease

for Crohn's Disease

2 sites incl. Louis

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT07782021·Phase 4

Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers

for Systemic Lupus Erythematosus

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 4 - 75

Code: NCT07791199·Phase 3

Apremilast and Adalimumab in Psoriatic Arthritis Patients

for Psoriatic Arthritis

Sponsor: Tanta University

Sex: All·Age: 18 - 70

Code: NCT07398651

Lead Exposure and Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Assiut University

Sex: All·Age: 20 - 50·Accepts healthy volunteers

Code: NCT07423312

Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Baylx Inc.

Sex: All·Age: 18 - 70

Code: NCT03828344·Phase 1

Autologous Hematopoietic Stem Cell Transplantation for Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tianjin Medical University General Hospital

Sex: All·Age: 18 - 60

Code: NCT06228781

Chronic Fatigue in Multiple Sclerosis: MS Copilot Boost Solution Compared to Standard Care

for Multiple Sclerosis

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT06386133

An AI-Based Erythema Measurement System for Psoriasis Lesions

for Psoriasis

Sponsor: Khon Kaen University

Sex: All·Age: 18 - 100

Code: NCT07494396

Ex Vivo Study of hAMSC Secretome in Inflammatory Bowel Disease: Effects on Inflammation and Fibrosis (TARGET)

for Inflammatory Bowel Diseases

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07721207

Assessing Psoriasis Treatment Outcomes

for Psoriasis

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07391423

A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus

for Multiple Sclerosis

Sponsor: Polpharma Biologics International AG

Sex: All·Age: 18 - 65

Code: NCT07606521·Phase 1

A Study of SL-325 in Crohn's Disease Patients

for Crohn's Disease

Sponsor: Shattuck Labs, Inc.

Sex: All·Age: 18 - 80

Code: NCT07753850·Phase 2

Serum Asprosin, Metabolic Syndrome, and Cardiometabolic Risk in Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793747

Disease Impact and Its Correlation With Disease Activity in Psoriatic Arthritis

for Psoriatic Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793773

Subclinical Hypothyroidism and Disease Activity in Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793786

Study to Characterise Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Anifrolumab Administered Subcutaneously (SC) or Intravenously (IV)

for Systemic Lupus Erythematosus

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT07688980·Phase 1

A Study to Evaluate the Equivalence of IBI3027 and Dupilumab Injection in Participants With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

Sponsor: Innovent Biologics (Suzhou) Co. Ltd.

Sex: All·Age: 18 - 75

Code: NCT07754786·Phase 3

A Study of Early Secukinumab Treatment in Moderate to Severe Hidradenitis Suppurativa Patients

for Hidradenitis Suppurativa

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07690319

Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease

for Crohn Disease

Sponsor: Nantes University Hospital

Sex: All·Age: 18 - 70

Code: NCT05584228

A Study to Investigate the Efficacy and Safety Profile of GM-XANTHO [GM-XAN003] in Patients With Psoriasis

for Psoriasis

Sponsor: Xantho Biotechnology Co., LTD

Sex: All·Age: 20+

Code: NCT06620692·Phase 2

Saphnelo Use in Females of Child-bearing Potential

for Systemic Lupus Erythematosus

Sponsor: AstraZeneca

Sex: Female·Age: 15 - 50

Code: NCT07431775

Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hunter College of City University of New York

Sex: All·Age: 18+

Code: NCT07552428

Evaluation of Serum IL-41 Level in Patients With Ankylosing Spondylitis and Psoriatic Arthritis

for Ankylosing Spondylitis

Sponsor: Assiut University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07648836

Combination CurQD and Vedolizumab in Ulcerative Colitis

for Ulcerative Colitis

1 site in New York

Sponsor: Ryan C Ungaro

Sex: All·Age: 18 - 80

Code: NCT07665294·Phase 4

Physical Activity Intervention for Individuals Newly Diagnosed With MS

for Multiple Sclerosis

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07731659

Development and Evaluation of the Effectiveness of the SMART-HAND Protocol for Hand Rehabilitation in Patients With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18+

Code: NCT07754552

Cone Evasion Walk Test in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Hacettepe University

Sex: All·Age: 18 - 70

Code: NCT07786987

Artificial Intelligence For Outcomes Research in Crohn's Disease: Digital Pathology Assessment of Fibrosis and Association With Patient History and Clinical Outcomes

for Crohn Disease

Sponsor: PharmaNest, Inc

Sex: All·Age: 18 - 80

Code: NCT07795476

Capillary Sampling in Clinical Populations Undergoing Monitoring

for Chronic Kidney Disease

Sponsor: University of Edinburgh

Sex: All·Age: 6+

Code: NCT07802665

Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study

for Inflammatory Bowel Disease (IBD)

Sponsor: University of British Columbia

Sex: All·Age: 19+

Code: NCT06109961·Phase 1, Phase 2

A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in Dermatology

for Chronic Dermatological Conditions

Sponsor: National University Hospital, Singapore

Sex: All·Age: 16+

Code: NCT07481019

Disulfiram in Rheumatoid Arthritis

for Rheumatoid Arthritis

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 75

Code: NCT07534332·Phase 2

Effectiveness of Upadacitinib and Biologics for the Achievement of Minimal Disease Activity in Adults With Moderate-to-Severe Atopic Dermatitis (RAMpUp)

for Atopic Dermatitis

Sponsor: AbbVie

Sex: All·Age: 18 - 64

Code: NCT07741838

A Study of Continued Use of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting

for Crohn Disease

Sponsor: Janssen Sciences Ireland UC

Sex: All·Age: 18+

Code: NCT07746765

Evaluating the Use of Oral Indapamide to Reduce Disabiltiy Progression in Progressive Multiple Sclerosis (MS)

for Multiple Sclerosis

Sponsor: Eva M.M. Strijbis

Sex: All·Age: 18 - 65

Code: NCT07765212·Phase 2

Effects of Kefir on Celiac Disease

for Celiac Disease

Sponsor: University Maribor

Sex: All·Age: 18+

Code: NCT07777666

Inflammation, Autoimmunity and Healthy Ageing in Menopause Transition. An Observational, Cross-sectional Study

for Autoimmune Diseases

Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Sex: Female·Age: 40 - 60

Code: NCT07784400

Inflammatory Biomarkers and Disease Activity in Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07788131

Mediterranean Dietary Intervention for HS

for Hidradenitis Suppurativa

1 site in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07800416

Randomized, Double-blind, Placebo-controlled Study of Nemolizumab in Chinese Subjects With Moderate-to-severe Atopic Dermatitis

for Atopic Dermatitis

Sponsor: Galderma R&D

Sex: All·Age: 12+

Code: NCT07762833·Phase 3

A Study on Infections in Adults With Ulcerative Colitis/Crohn's Disease

for Ulcerative Colitis

1 site in Cambridge

Sponsor: Takeda

Sex: All·Age: 65+

Code: NCT07250815

Phase Ib/II Study of SYS6020 in Relapsing/Refractory Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Tongji Hospital

Sex: All·Age: 18 - 65

Code: NCT07756268·Phase 1, Phase 2

A Real-world Study of Patients With Hidradenitis Suppurativa and High Cardiovascular Risk or Established Coronary Plaque Treated With Secukinumab

for Hidradenitis Suppurativa

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT07454889

A Trial in Healthy Adult Participants and Adults With Autoimmune Disease to Test How HBM7020 is Tolerated and Absorbed in the Body

for Rheumatoid Arthritis

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07649265·Phase 1

A Study of Guselkumab Given After Ustekinumab in Participants With Moderate to Severe Psoriasis in Routine Clinical Practice

for Psoriasis

Sponsor: Janssen-Cilag Kft.

Sex: All·Age: 18+

Code: NCT07746583

Apply to this trial

PLasmatic Extracellular Vesicles AS Biomarkers of nEural Tissue Damage

for Multiple Sclerosis

Sponsor: Roberto Furlan

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07769294

Effects of Face-to-Face Versus Telerehabilitation-Based Circuit Training in People With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18 - 65

Code: NCT07770620

A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune Diseases

for Systemic Lupus Erythematosus

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT07782450·Phase 1, Phase 2

Deciphering the Genetic Architecture of Autoimmune Diseases

for Autoimmune Diseases

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 18 - 115

Code: NCT06948110

Apply to this trial

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Autoimmune disease clinical trials — common questions

Are autoimmune disease clinical trials free to join?

Yes. Participating in a autoimmune disease clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a autoimmune disease clinical trial?

Each autoimmune disease study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a autoimmune disease trial near me?

Use the location controls above. We'll show recruiting autoimmune disease trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many autoimmune disease trials are recruiting right now?

We're currently tracking roughly 663 recruiting autoimmune disease trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Autoimmune disease trials by city

Birmingham, AL Boston, MA Chicago, IL San Francisco, CA Los Angeles, CA Aurora, CO Seattle, WA Ann Arbor, MI La Jolla, CA Cleveland, OH Lancaster, CA Miami, FL

Conditions in this area

Rheumatoid arthritis Psoriatic arthritis Lupus (SLE)Psoriasis Atopic dermatitis / eczema Hidradenitis suppurativa Autoimmune diseases (general)Multiple sclerosis Crohn's disease Ulcerative colitis Inflammatory bowel disease (IBD)Myasthenia gravis Celiac disease