Gastroenterology Clinical Trials

Recruiting gastroenterology studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat gastroenterology. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting gastroenterology studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting gastroenterology trials

Within

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Liver Steatosis in Pediatric CD Patients

for Celiac Disease in Children

Sponsor: University of Palermo

Sex: All·Age: 1 - 14

Code: NCT06206616

Apply to this trial

Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease

for Crohn's Disease

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06510296

Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Bausch Health Americas, Inc.

Sex: All·Age: 5 - 17

Code: NCT05976802·Phase 4

SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 site in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 12 - 20

Code: NCT03867487·Phase 2

Effect Of Percutaneous Electrical Nerve Field Stimulation on Symptom Control/Nervous System Activity in Patients w/Diabetes Types 1/2

for Diabetes

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18 - 60

Code: NCT06783504

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

Erlotinib for Hepatocellular Carcinoma Chemoprevention

for Cirrhosis, Liver

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT04172779·Phase 2

Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy

for Reflux Disease, Gastro-Esophageal

Sponsor: Hospital de Mataró

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07607067

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07206589

Ex Vivo Study of hAMSC Secretome in Inflammatory Bowel Disease: Effects on Inflammation and Fibrosis (TARGET)

for Inflammatory Bowel Diseases

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18+

Code: NCT07721207

Microbiota trAnSplant ThERaPy In hEpatiC Encephalopathy (MASTERPIECE)

for Hepatic Encephalopathy

3 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT07528690·Phase 2

Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease

for Crohn Disease

Sponsor: Nantes University Hospital

Sex: All·Age: 18 - 70

Code: NCT05584228

Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 20 - 78

Code: NCT07670871

Emerging Indications for Hyperbaric Oxygen Treatment

for Post-COVID-19 Condition

Sponsor: Jay C. Buckey Jr.

Sex: All·Age: All ages

Code: NCT07240649·Phase 4

Palatable Elemental Diet for Gastrointestinal Symptoms in Chronic Pancreatitis

for Chronic Pancreatitis

1 site in Redwood City

Sponsor: Stanford University

Sex: All·Age: 18 - 75

Code: NCT07559448

Treatment of Chinese Adult Subjects With Moderate to Severe Crohn's Disease With Tabellvi®

for Crohn's Disease

Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Sex: All·Age: 18 - 70

Code: NCT07663526·Phase 4

Online Pain Education for Crohn's Disease and Ulcerative Colitis

for Crohn's Disease

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT07671313

Personalized Approach to Celiac Disease Diagnosis

for Celiac Disease

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07701655

Xylitol Use for Decolonization of C. Difficile in Patients With IBD

for Inflammatory Bowel Diseases

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05852587·Phase 1

Efficacy and Safety of CDED With Anti-TNF-α Biologics in Crohn's Disease

for Crohn Disease

Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07344428

Microbiome-targeted Diet Therapy in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07520461

Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy

for Cirrhosis

Sponsor: Hospital do Divino Espírito Santo de Ponta Delgada

Sex: All·Age: 18+

Code: NCT07668778·Phase 3

Retrospective Observational Multicenter Study on the Treatment Patterns, Extra-Intestinal Manifestations, Resource Utilisation, and Outcomes of Patients With Inflammatory Bowel Disease in Dutch Hospitals

for Crohn Disease

Sponsor: LOGEX

Sex: All·Age: 18+

Code: NCT07682038

Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07456566

Aquamin® for Prevention of Ulcerative Colitis J-Pouch-associate Intestinal Inflammation

for Ulcerative Colitis

1 site in Ann Arbor

Sponsor: Muhammad N Aslam, MD

Sex: All·Age: 5 - 80

Code: NCT07501078·Phase 2

Apply to this trial

Gastric Electrical Stimulation for Abdominal Pain in Patients With Gastroparesis

for Gastroparesis

1 site in Louisville

Sponsor: University of Louisville

Sex: All·Age: 18+

Code: NCT07556237

EUS Procedures Using RIVOS™ EUS Access Device

for Pancreatic Fluid Collections

1 site in Orlando

Sponsor: Orlando Health, Inc.

Sex: All·Age: 18+

Code: NCT07696572

Apply to this trial

Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Disease

1 site in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 85

Code: NCT07619547

Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis

for Crohn's Disease

9 sites incl. Lakeland

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT07697456·Phase 2

VR Pilot for Pancreatitis

for Chronic Pancreatitis

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 75

Code: NCT06362187

Virtual Poetry Workshops to Enhance Patient Well Being and Reduce Anxiety

for Dyspepsia

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT07717541

Apply to this trial

A Study on Infections in Adults With Ulcerative Colitis/Crohn's Disease

for Ulcerative Colitis

1 site in Cambridge

Sponsor: Takeda

Sex: All·Age: 65+

Code: NCT07250815

A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease

for Crohn's Disease

Sponsor: Takeda

Sex: All·Age: 18 - 75

Code: NCT07403968·Phase 2

A Phase II Study of H021 Enteric-coated Tablets for Moderately to Severely Active Crohn's Disease

for Crohn's Disease

3 sites incl. Hamden

Sponsor: Jiangsu Carephar Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07677514·Phase 2

A Surgical Procedure (Total Pancreatectomy) With a Transplant Procedure (Islet Cell Autotransplantation) for the Treatment of Chronic Pancreatitis and Benign Pancreatic Tumors

for Benign Pancreatic Neoplasm

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18+

Code: NCT05453851·Phase 1, Phase 2

Effect of Insulin Lowering on Lipogenesis

for Hyperinsulinemia

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT07403604·Phase 1

Apply to this trial

Molecular Characterization of Autoimmune Hepatitis: A Lipidomic Approach

for Autoimmune Hepatitis

Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

Sex: All·Age: 18+

Code: NCT07644936

Development of a Predictive Score for the Risk of Infection in the Immediate Post-liver-transplant Period

for Cirrhosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07647978

Stopping PPI Therapy in Inactive IBD

for Ulcerative Colitis (UC)

Sponsor: University of Nottingham

Sex: All·Age: 16+

Code: NCT07691138·Phase 4

Apply to this trial

Heart Rate Variability (HRV) Biofeedback to Treat Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18 - 65

Code: NCT05892159

Proof of Concept Study Evaluating the Efficacy and Safety of ATH-063 Treatment in Patients With Relapsed/Refractory Moderately to Severely Active Ulcerative Colitis (UC)

for Ulcerative Colitis

2 sites incl. Miami

Sponsor: Athos Therapeutics Inc

Sex: All·Age: 18 - 75

Code: NCT07513181·Phase 2

Impact of Propranolol on the Prognosis of Patients With Decompensated Cirrhosis and MELD Score > 9

for Cirrhosis

Sponsor: General Hospital of Shenyang Military Region

Sex: All·Age: 18+

Code: NCT07652203

Combination CurQD and Vedolizumab in Ulcerative Colitis

for Ulcerative Colitis

1 site in New York

Sponsor: Ryan C Ungaro

Sex: All·Age: 18 - 80

Code: NCT07665294·Phase 4

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

6 sites incl. Kansas City

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2

Apply to this trial

A Study of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis

for Crohn Disease

Sponsor: Janssen-Cilag Pharma GmbH

Sex: All·Age: 18+

Code: NCT07606339

Personalized Nutritional Intervention in Patients Undergoing TIPS Insertion for Refractory Ascites to Prevent Overt Hepatic Encephalopathy

for Cirrhosis

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All·Age: 18 - 70

Code: NCT07634237

NaviCam Patency Capsule to Verify Gastrointestinal Patency

for Intestinal Stricture

1 site in Downers Grove

Sponsor: AnX Robotica Corp.

Sex: All·Age: 22+

Code: NCT07649720

A Study to Assess Concentration of TREMFYA in Breast Milk of Lactating Women Who Are Receiving TREMFYA Therapeutically

for Psoriasis

1 site in Chapel Hill

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18+

Code: NCT07654751·Phase 4

Role of Bile Acids and Microbiota in Clostridioides Difficile Infection in Ulcerative Colitis

for Ulcerative Colitis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: Up to 17

Code: NCT06228352

Apply to this trial

Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD

for Ulcerative Colitis

1 site in San Antonio

Sponsor: Spyre Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07652294·Phase 2

Bumetanide vs. Furosemide in Cirrhosis

for Cirrhosis

1 site in Salt Lake City

Sponsor: Stacy Johnson

Sex: All·Age: 18+

Code: NCT06941415·Phase 3

Apply to this trial

A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurrence and the Effect of Risk Profile Disclosure on Patient Quality of Life and Fear of Cancer

for Barrett Esophagus

Sponsor: University Hospital, Antwerp

Sex: All·Age: 18+

Code: NCT07455422

4D-Flow MRI Assessment of Portal Hypertension and TIPS Outcomes in Cirrhosis

for Cirrhosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07554183

Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM

for Type 2 Diabetes

Sponsor: Shanghai Jiao Tong University School of Medicine

Sex: All·Age: 18 - 65

Code: NCT07570810

A Multi-Center Randomized Controlled Trial on the Impact of Disease Subtype-Based Active Video Education on Bowel Preparation Quality in Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

Sponsor: Jie Liang

Sex: All·Age: 18 - 75

Code: NCT07582731

Immune Repertoire Decoding for Chronic Pancreatitis-to-Pancreatic Cancer Risk Stratification

for Chronic Pancreatitis

Sponsor: Changhai Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07612566

Venous Resection in Patients Undergoing Pancreatic Surgery

for IPMN, Pancreatic

Sponsor: Sahlgrenska University Hospital

Sex: All·Age: 18+

Code: NCT07621029

IBDminds - Mapping the Influence of aNxiety and DepreSsion on IBD

for Inflammatory Bowel Diseases

Sponsor: The Royal Wolverhampton Hospitals NHS Trust

Sex: All·Age: 16+

Code: NCT07175454

Disposable Endoscope Platform in Third Space Endoscopic Procedures

for Achalasia

1 site in Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT06738628

Gastroenterology clinical trials — common questions

Are gastroenterology clinical trials free to join?

Yes. Participating in a gastroenterology clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a gastroenterology clinical trial?

Each gastroenterology study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a gastroenterology trial near me?

Use the location controls above. We'll show recruiting gastroenterology trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many gastroenterology trials are recruiting right now?

We're currently tracking roughly 370 recruiting gastroenterology trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Gastroenterology trials by city

Boston, MA Los Angeles, CA Indianapolis, IN Chicago, IL Ann Arbor, MI Cleveland, OH Orlando, FL Aurora, CO Birmingham, AL Miami, FL La Jolla, CA Palo Alto, CA

Conditions in this area

Crohn's disease Ulcerative colitis Inflammatory bowel disease (IBD)Cirrhosis / liver disease Non-alcoholic fatty liver disease (NAFLD)Chronic pancreatitis Gastroparesis Barrett's esophagus Celiac disease