DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTance

Sponsor
NHS Greater Glasgow and Clyde
Study ID
NCT04860011
Phase
PHASE3
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

To assess the effect of dapagliflozin compared with metolazone, added to furosemide, on diuresis and decongestion in hospitalised heart failure patients with diuretic resistance, and renal impairment. The primary analysis will be in patients with HFrEF but patients with HFpEF will also be recruited in an ancillary study and included in supplementary analyses.

Key Dates

Start date
Apr 27, 2021
Status verified
Apr 2023
Primary completion
Oct 30, 2022
Completion
Apr 3, 2023

Study Design

Enrollment
61 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: SGLT2i
    Sodium-glucose Co-transporter-2 inhibitors
  • Experimental: Thiazide
    Thiazide or thiazide like diuretic

Primary Outcome Measure

Diuretic effect [ Time Frame: from randomisation to 48 hours ]

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