Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis
- Sponsor
- Second Affiliated Hospital of Nanchang University
- Study ID
- NCT04944069
- Status
- Unknown
Conditions
- EGFR Activating Mutation
- Leptomeningeal Metastasis
- NSCLC
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 75 Years
- Healthy Volunteers
- Not accepted
Interventions
- Almonertinib — DRUG110 mg oral once daily
- Bevacizumab — DRUG15 mg/kg intravenous on Day 1 of 21 day cycles (every 3 weeks)
Study Details
A prospective, open-label, multi-center, single-arm study of Almonertinib combined With Bevacizumab for EGFR-mutant NSCLC patients with leptomeningeal metastasis.
Key Dates
- First listed
- Jun 29, 2021
- Start date
- Jul 31, 2021
- Status verified
- May 2021
- Primary completion
- Mar 31, 2024
- Completion
- Mar 31, 2025
Study Design
- Enrollment
- 69 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: Almonertinib With BevacizumabAlmonertinib 110 mg oral once daily with Bevacizumab 15 mg/kg intravenous on Day 1 of 21 day cycles (every 3 weeks)
Primary Outcome Measure
Overall Survival (OS) [ Time Frame: From date of enrollment until the date of death, up to 2 years ]
Central Contacts
- Liu Anwen, PhD+8613767120022
- Huang Long, PhD+8613699549060
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