Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University
Study ID
NCT05596474
Status
Recruiting
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Conditions

  • Health Care Utilization
  • Healthy Aging

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Beet-root juice — DIETARY_SUPPLEMENT
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.
  • red-light therapy — RADIATION
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.
  • Placebo — DIETARY_SUPPLEMENT
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.
  • sham light — RADIATION
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Study Details

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question: Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement? Does red light therapy improve forearm muscle endurance compared to a sham light exposure? Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Key Dates

Start date
Sep 9, 2022
Status verified
Mar 2024
Primary completion
Aug 31, 2024
Completion
Aug 31, 2024

Study Design

Enrollment
10 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Beet-root juice plus red-light therapy
  • Sham Comparator: Beet-root juice plus sham light therapy
  • Placebo Comparator: Placebo plus red-light therapy
  • Active Comparator: Placebo plus sham light therapy

Primary Outcome Measure

Total forearm work performed [ Time Frame: During the forearm exercise fatigue protocol lasting up to 45 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wake Forest UnivesityWinston-SalemNorth Carolina27106
Andrew D Wells, Ph.D.
[email protected]
336-758-5837

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By research site
Wake Forest Univesity· Winston-Salem, NC

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