Mind and Skin - the Neurocutaneous Axis in Atopic Eczema

Sponsor
King's College London
Study ID
NCT05790330
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
12 Years - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Methotrexate — DRUG
    As per usual standard of care
  • Dupilumab — DRUG
    As per usual standard of care

Study Details

'Mind and Skin': A prospective cohort study evaluating the impact of inflammation, itch and sleep disturbance on the brain, mental health and cognition, in patients with severe atopy.

Key Dates

Start date
Mar 10, 2023
Status verified
May 2024
Primary completion
Dec 1, 2025
Completion
Jun 1, 2027

Study Design

Enrollment
90 participants (estimated)

Arms

  • Arm: Severe eczema
    Patients aged 12-18 who have been diagnosed with atopic eczema and require starting systemic therapy.
  • Arm: Less severe eczema
    Patients aged 12-18 who have been diagnosed with atopic eczema and require topical steroid therapy only.
  • Arm: Healthy controls
    Patients ages 12-18 who do not have atopic eczema.

Primary Outcome Measure

Eczema Area and Severity Index (EASI) Score [ Time Frame: 6 months ]

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