Comparing the Diagnostic Sensitivity and Specificity of Pleural Fluid N-Terminal Pro B-type Natriuretic Peptide (NT-proBNP) and Other Biochemical Gradient Criteria in Distinguishing Heart Failure and Non-heart Failure Related Pleural Effusions (CENTRE Study)

Sponsor
Chinese University of Hong Kong
Study ID
NCT05797649
Status
Recruiting
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Conditions

  • Cirrhosis
  • Fluid Overload
  • Heart Failure
  • Hypoalbuminemia
  • Infections
  • Malignant Neoplasm
  • Pleural Effusion
  • Renal Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

To assess the discriminative properties of pleural fluid (PF) N-terminal-proB-type-natriuretic-peptide (NTproBNP) levels in identifying heart failure (HF)-associated pleural effusions (PE).

Key Dates

First listed
Apr 4, 2023
Start date
Jul 1, 2023
Status verified
Nov 2024
Primary completion
Nov 30, 2025
Completion
Nov 30, 2025

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Heart Failure-Associated Pleural Effusion
    Patients with pleural effusion with an underlying aetiology of heart failure
  • Arm: Control group
    Patients with pleural effusion due to exudative, or non-fluid overload causes

Primary Outcome Measure

Comparison of the diagnostic performance of PF NTproBNP level in the diagnosis of HF-associated pleural effusions with other conventional biochemical criteria [ Time Frame: 24 months ]

Central Contacts

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