Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Sponsor
Nantes University Hospital
Study ID
NCT06059313
Status
Recruiting
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Conditions

  • Behavioral Variant of Frontotemporal Disorder (bvFTD)
  • Bipolar Disorder
  • Frontal Variant of Alzheimer Disease
  • Phenocopy Frontotemporal Dementia (phFTD)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Submission of the NEO-PI-3 questionnaire — OTHER
    The questionnaire contains 240 statements. For each statement, the patient chooses the answer that best corresponds to their choice (FD: strongly disagree - D: disagree - N: neutral - A: agree - FA: strongly agree).
  • Submission of the Interpersonal Reactivity Index questionnaire (IRI) — OTHER
    The test assesses two cognitive and two affective components of empathy that influence each other and affect attitudes and behaviors toward others.

Study Details

Damages in frontal area present in neurodegenerative disease (frontotemporal degeneration, frontal variant of Alzheimer disease) and in psychiatric disease (bipolar disorder) can affect behavior and cognition including social cognition. Symptoms vary both quantitatively and qualitatively from disease to another and from person to person. It cannot be completely excluded that in some cases, factors of susceptibility such as premorbid personality traits lead to frontal fragility. The study will assess the relationship between premorbid profile using NEO-PI 3 inventory and cognitive and behavioral/psychobehavioral manifestations in patients with behavioral variant of frontotemporal disorder (bvFTD), phenocopy frontotemporal dementia (phFTD), frontal variant of Alzheimer disease, bipolar disorder characterized with frontal damages.

Key Dates

First listed
Sep 28, 2023
Start date
Dec 14, 2023
Status verified
Jun 2026
Primary completion
Dec 14, 2026
Completion
Dec 14, 2026

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Behavioral variant of frontotemporal disorder (bvFTD)
    A group of participants who fulfill Rascovsky criteria (2011) for behavioural variant Frontotemporal Dementia
  • Arm: Phenocopy frontotemporal dementia (phFTD)
    A group of participants who fulfill who fulfill Rascovsky criteria (2011) for possible behavioural variant Frontotemporal Dementia and have no imaging abnormalities.
  • Arm: Frontal variant of Alzheimer disease
    A group of participants who fulfill Ossenkopele criteria (2022)
  • Arm: Bipolar disorder
    A group of participants who fulfill CIM 10 criteria

Primary Outcome Measure

Premorbid personality traits [ Time Frame: Baseline ]

Central Contacts

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