Effects of Heart Rate Oscillations During Meditation on Plasma Biomarkers of Alzheimer's Disease

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT06210035
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Belly-focus meditation — BEHAVIORAL
    Participants will engage in concentration meditation for 40 minutes every day for a week. They will focus on the sensations around the belly.
  • Belly-focus meditation with slow breathing — BEHAVIORAL
    Participants will engage in concentration meditation and slow breathing for 40 minutes every day for a week. They will focus on the sensations around the belly while breathing slowly.

Study Details

In the current study, we will examine how two types of concentration meditation practices affect plasma biomarkers of Alzheimer's Disease (AD). We will also examine the effects of the two types of meditation practices on emotional well-being and episodic memory. Healthy adults aged 18-35 who meet all eligibility criteria will be invited to this study. Participants will be asked to engage in one week of daily meditation practice or no-intervention control task at home. They will also be asked to visit the lab twice, once before and once after the intervention, to provide blood samples to assess plasma biomarkers of AD and to complete emotion questionnaires and a memory test.

Key Dates

Start date
Jan 29, 2024
Status verified
Dec 2025
Primary completion
May 3, 2024
Completion
May 3, 2024

Study Design

Enrollment
94 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Belly-focus concentration meditation
    Participants will engage in concentration meditation for 40 minutes every day for a week while recording heart rate. They will focus on the sensations around the belly.
  • Experimental: Belly-focus concentration meditation with slow breathing
    Participants will engage in concentration meditation and slow breathing for 40 minutes every day for a week while recording heart rate. They will focus on the sensations around the belly while breathing slowly.
  • No Intervention: No-intervention control
    Participants will rest quietly for 40 minutes every day for a week while recording heart rate.

Primary Outcome Measure

Change in Plasma Amyloid Beta (Aβ) Levels [ Time Frame: Measured from blood draws before and after a one-week intervention ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Southern CaliforniaLos AngelesCalifornia90089-

Find similar trials in Los Angeles, CA

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
University of Southern California· Los Angeles, CA

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