Inflammation in Acute Cardiovascular Diseases - the CArdiovascular Inflammation Registry (CAIR)

Sponsor
King's College London
Study ID
NCT06411340
Status
Not Yet Recruiting

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Conditions

  • Cardiovascular Diseases
  • Heart Diseases
  • Heart Failure
  • Inflammation
  • Myocardial Infarction
  • Myocarditis
  • Pericarditis

Eligibility Criteria

Sex
ALL
Age
13 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Observation — OTHER
    Observation

Study Details

Following acute cardiovascular injury, inflammation is vital to activate reparative mechanisms. However, there is compelling evidence implicating excessive inflammation and dysregulated resolution in fibrosis, ventricular remodelling, and heart failure (HF). Recently, the anti-inflammatory agent colchicine reduced cardiovascular events after myocardial infarction (MI) compared to placebo, indicating that targeting inflammation in acute cardiovascular conditions is feasible. Several acute cardiovascular conditions are characterised by inflammation, including myocarditis, MI, and acute heart failure. However, there is large variability in definition, epidemiology, clinical presentation, pathophysiology, and natural history of acute inflammatory cardiovascular diseases. This relates, in part, to the difficulty in performing adequately powered studies. Clinical studies that include sufficient patients and extended observation periods are necessary to address some of these knowledge gaps. This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases characterised by inflammation in an observational-based registry. By doing so, the investigators hope to understand the contribution of inflammation to the pathophysiology of acute cardiovascular disease, improve risk stratification, and identify potential novel therapeutic targets.

Key Dates

First listed
May 13, 2024
Start date
Jul 31, 2024
Status verified
May 2024
Primary completion
Jul 31, 2034
Completion
Jul 31, 2039

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Acute inflammatory cardiac disease
    This registry aims to collate routinely collected clinical data on patients with acute cardiovascular diseases.

Primary Outcome Measure

All-cause mortality [ Time Frame: 1 year ]

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