Investigation of VAP-1 Expression and Tissue Blood Flow by PET-MRI in Patients With Crohn's Disease

Sponsor
Turku University Hospital
Study ID
NCT06555042
Status
Recruiting
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Conditions

  • Crohn Colitis
  • Crohn Disease
  • Crohn Disease in Remission
  • Crohn Disease of Small Intestine
  • Crohn's Ileocolitis
  • Inflammatory Bowel Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Study Details

This is an observational, single center, imaging study. The CD patients with active disease will be assessed by \[68Ga\]Ga-DOTA-Siglec-9 and \[15O\]H2O PET/MRE. Patients with high clinical suspicion of small intestine's CD in outpatient gastroenterology clinic of Turku University Hospital will be recruited. The patients must fulfil the eligibility criteria and give their signed approvement prior to their enrolment into the study. 20 patients with high suspicion of active small bowels CD will be enrolled to being evaluated for potential participation in this study. In patients with diagnosed small bowels CD, PET-MRE will be repeated 3 months after the initial imaging (and based on clinical diagnostic started medication) to verify disease remission/inadequacy of the treatment. Assessments for CD clinical disease activity will be performed at screening and \[68Ga\]Ga-DOTA-Siglec-9 and \[15O\]H2O PET/MRE assessments will be performed within a month for each patient. After PET/MRE all patients can be treated according to patients' needs with immunosuppressive drugs. Follow-up visits are organized at after PET/MRE imaging at gastroenterology outpatient clinic.

Key Dates

First listed
Aug 15, 2024
Start date
Sep 30, 2024
Status verified
Aug 2024
Primary completion
Jan 1, 2026
Completion
Jun 6, 2026

Study Design

Enrollment
20 participants (estimated)

Primary Outcome Measure

VAP-1 expression in the small bowel of patients with Crohn's disease [ Time Frame: 18 months ]

Central Contacts

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