Characterization of the Fungal Immunopeptidome Involved in the Immunopathological Mechanisms of Psoriasis

Sponsor
Assistance Publique - Hôpitaux de Paris
Study ID
NCT06610942
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Psoriasis is a chronic immune-mediated skin disorder characterized by inflammatory cutaneous plaques and, occasionally, arthritis, affecting 60 million adults and children worldwide. Although a variety of treatments have been developed aimed to relieve the associated symptoms, there is yet no permanent cure for psoriasis. TH17 type immunity, via the production of IL-17A and other pro-inflammatory cytokines, are considered to play a central role in the pathogenesis of this disease. Moreover, experimental evidence obtained in animal models, points to human mycobiota as a trigger for the initiation and/or progression of psoriasis. Therefore, human studies are required to better characterize the major fungi implicated in the local and systemic inflammatory responses, as well as to determine the immunopeptidome that shapes the pathogenic T cell receptor repertoire. We will explore the hypothesis that commensal fungi could participate in the chronic inflammatory immune response underlying the pathogenesis of human psoriasis via the recognition of cutaneous fungal antigens and/or via a gut-skin mycobiome cross-reactive mechanism

Key Dates

First listed
Sep 24, 2024
Start date
Oct 31, 2025
Status verified
Aug 2025
Primary completion
Oct 31, 2027
Completion
Oct 31, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Adult patients with psoriasis who have failed local treatment
  • Arm: "Healthy" controls (skin)
  • Arm: "Healthy" controls (stools)

Primary Outcome Measure

Determining the commensal fungi responsible for the immunopathological response in psoriasis. [ Time Frame: 2 years ]

Central Contacts

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