Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study

Sponsor
University Hospital, Grenoble
Study ID
NCT06626308
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • brain functional MRI — OTHER
    visual protocol stimulation during brain functional MRI

Study Details

The goal of this clinical trial is to investigate if new, early biomarkers of the disease are available in presymptomatic genetic carriers of Huntington\'s diesase compared to healthy subjects. The main questions it aims to answer are: Does functional brain MRI is able to detect early biomarkers of the disease in genetic carriers? Does gait study by a virtual reality device can detect early biomarkers of the disease in genetic carriers? Researchers will compare genetic carriers and healthy subjects to see if new, early biomarkers of the disease can be detected .

Key Dates

First listed
Oct 3, 2024
Start date
Feb 20, 2025
Status verified
Jan 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: neuroimaging assessment
    visual stimulation protocol during functional MRI session

Primary Outcome Measure

Brain functional MRI biomarker investigation [ Time Frame: from the enrollement to the end of the investigation: 2 months ]

Central Contacts

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