fMRI and Opioid Abstinence

Part of paid clinical trials in Hartford, Connecticut.

Sponsor
Yale University
Study ID
NCT06651333
Status
Recruiting
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Conditions

  • Drug Use Disorder
  • Opioid Abuse
  • Opioid Dependence
  • Opioid Use
  • Opioid-Related Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • fMRI — DIAGNOSTIC_TEST
    Participants will be performing tasks while undergoing fMRI. Tasks include Stroop task, Emotion-regulation task and an Ambiguity reward task, Drug cue task, and Cognitive behavioral therapy task. Participants are not presented with any specific stimulus.

Study Details

This project examines functional connectivity patterns associated with subsequent relapse to illicit opioids during treatment for OUD.

Key Dates

First listed
Oct 21, 2024
Start date
Dec 12, 2024
Status verified
Aug 2026
Primary completion
Nov 30, 2029
Completion
Nov 30, 2029

Study Design

Enrollment
240 participants (estimated)

Arms

  • Arm: Methadone
    Participants initiated into methadone within the past 6 months will receive fMRI and cognitive assessment battery.
  • Arm: Buprenorphrine
    Participants initiated into buprenorphine within the past 6 months will receive fMRI and cognitive assessment battery.

Primary Outcome Measure

Illicit opioid-use [ Time Frame: At monthly visits for 6 months following neuroimaging ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Hartford HealthcareHartfordConnecticut06102
Monica Holler
[email protected]
203-278-1107
Vaughn Steele (PRINCIPAL_INVESTIGATOR)
The APT FoundationNew HavenConnecticut06520-

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By research site
Hartford Healthcare· Hartford, CTThe APT Foundation· New Haven, CT

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