Addiction medicine Clinical Trials

Recruiting addiction medicine studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat addiction medicine. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting addiction medicine studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting addiction medicine trials

Within

Dynamic Treatment Regimes for Opioid Use Disorder

for Opioid Use Disorder

1 site in Irvine

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07011758·Phase 2

Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans

for Opioid Use Disorder

1 site in Northport

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06766331

A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver Disease

for Alcohol Use Disorder

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07553377

A Mindfulness-based Intervention for Sexual Assault Survivors

for Alcohol Misuse

1 site in Atlanta

Sponsor: Georgia State University

Sex: All·Age: 18 - 24

Code: NCT07515586

Family-Focused Study to Support Medication for Opioid Use Disorder

for Opioid Use Disorder

2 sites incl. Chicago

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07451197

Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania

for Alcohol Use Disorder

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07475988

Permanent Supportive Housing Overdose Prevention+ Study

for Overdose

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07214519

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

for Alcohol Use Disorder

1 site in Portland

Sponsor: Washington State University

Sex: All·Age: 18+

Code: NCT07171359

Apply to this trial

A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults

for Alcohol Use Disorder

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 29

Code: NCT07214831

Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT

for Prevention

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT07672457

Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon

for Alcohol Use Disorder

Sponsor: University of Buea

Sex: All·Age: 18+

Code: NCT07677449

Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder

for Cannabis Use

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 15 - 21

Code: NCT07634835

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

for Tobacco Use Disorder

1 site in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07714200

Yuva Sath: A Peer-led Behavioral Intervention to Support Substance Use Treatment and HIV Prevention Among Young People Who Inject Drugs in India

for Hiv

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 29

Code: NCT06510192

ETSF for Latinx Young Adults with Alcohol Use Disorder

for Alcohol Use Disorder (AUD)

Sponsor: Tulane University

Sex: All·Age: 18 - 29

Code: NCT06722690

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

for Substance Use

3 sites incl. Los Angeles

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07409350

Improving HIV Prevention and Substance Use Post-Sexual Assault Services

for HIV Infections

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 17 - 25

Code: NCT07225062

Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care

for Smoking

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06839729·Phase 1

Daridorexant for Alcohol Use Disorder

for Alcohol Use Disorder

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT07532252·Phase 2

Pomegranate Dietary Supplements in AUD and ALD

for Alcohol Use Disorder

1 site in Louisville

Sponsor: University of Louisville

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07678567

Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders

for Alcohol Use Disorder (AUD)

Sponsor: University of Pittsburgh

Sex: Male·Age: 18 - 59

Code: NCT06652802

Chatbot for Online Support Groups to Treat Tobacco Addiction

for Tobacco Dependence

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06952725

Testing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery (CalmiFy II)

for Alcohol Use Disorder (AUD)

Sponsor: Washington State University

Sex: All·Age: 18 - 35

Code: NCT07088237

Evaluating a Digital Toolkit for IPV

for Opioid Use Disorder

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07600307

Trial of Tirzepatide for the Treatment of Cannabis Use Disorder

for Cannabis Use Disorder

Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All·Age: 18 - 70

Code: NCT07468552·Phase 2

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

for Opioid Use Disorder

4 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07361432·Phase 3

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

for Opioid Use Disorder

1 site in Detroit

Sponsor: Wayne State University

Sex: All·Age: 21 - 60

Code: NCT04231708·Phase 2

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

Apply to this trial

Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

for Opioid Use Disorder

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT07148206·Phase 3

Preventing Overdose and Promoting Recovery Through Court Navigation

for Substance Use Disorder (SUD)

2 sites incl. South Bend

Sponsor: RTI International

Sex: All·Age: 18 - 100

Code: NCT07700407

Developing and Testing an Online Intervention for Alcohol and Cannabis Misuse and Healthy Relationship Skills Among Young Adult Couples

for Alcohol Drinking

Sponsor: University of Washington

Sex: All·Age: 18 - 29·Accepts healthy volunteers

Code: NCT06422299

Mindfulness-Based Substance Use Prevention (MINDS-UP)

for Substance Use

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 10 - 14·Accepts healthy volunteers

Code: NCT06593470

ChatGPT-Supported Text Messaging Program for Smoking Cessation

for Smoking Cessation

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07079306

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

for Homelessness

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07141394

Facilitation to Increase Tobacco Treatment

for Serious Mental Illness

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07455526

Improving Hospital-To-Methadone Clinic Connection Using Implementation Support for Patients With Opioid Use Disorder

for Opioid Use Disorder

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07568847

Development of a Mobile Health Intervention to Support Functioning of Veterans With Substance Use Disorders

for Substance Use

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07645131

Combination Therapy for Alcohol Use Disorder

for Alcohol Use Disorder

1 site in Havre de Grace

Sponsor: Johns Hopkins University

Sex: All·Age: 21 - 65

Code: NCT07249554·Phase 2

Deaf CBT-TS to Reduce Suicide Risk

for Depression - Major Depressive Disorder

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT07279363

Remote Interventions for Menthol Cigarette Use

for Cigarette Smoking

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07356297

Smart Talk: Cannabis Awareness and Prevention Curriculum Evaluation

for Cannabis Use

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 10 - 20·Accepts healthy volunteers

Code: NCT07357454

Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)

for Opioid Use Disorder

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07607743

Pregnenolone for Cannabis Use Disorder and Depression

for Cannabis Use Disorder

2 sites incl. Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 50

Code: NCT07685964·Phase 1, Phase 2

Emotion Regulation Program for Substance Use Disorders

for Substance Use Disorder (SUD)

Sponsor: The Catholic University of Korea

Sex: All·Age: 19 - 65

Code: NCT07698821

Methadone Expansion in Detention Though the Hospital/Clinic Designation

for Opioid Use Disorder

Sponsor: Brendan Saloner

Sex: All·Age: 18+

Code: NCT07707934

Improving Access to Opioid Use Disorder Treatment Among Marginalized Patients With a Tailored Telehealth Intervention

for Opioid Use Disorder

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06341608

A Bundled Intervention to End Opioid Overdoses

for Opioid Use Disorder

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 19+

Code: NCT07485335·Phase 4

Pilot Study: Effects of Nimodipine on Alcohol Drinking

for Alcohol Use Disorder

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 21 - 50

Code: NCT06900998·Phase 2

The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study

for Opioid Use Disorder

4 sites incl. Miami

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07216963

Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

for Obesity

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07224087·Phase 1

A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

for Obesity

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07398404·Phase 1, Phase 2

High Intensity Use of Urgent and Emergency Care: A Mixed-Methods Study

for High Intensity Use of Urgent and Emergency Care

Sponsor: Bournemouth University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07630012

Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs

for HEPATITIS C (HCV)

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07631559

LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School

for Substance-related Disorders

Sponsor: Prevention Strategies, LLC

Sex: All·Age: 15 - 21·Accepts healthy volunteers

Code: NCT07655609

Effects of Nimodipine on Alcohol Drinking

for Alcohol Use Disorder

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 21 - 50

Code: NCT07681869·Phase 2

CBITS-RTM Pilot Study

for PTSD - Post Traumatic Stress Disorder

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 13+

Code: NCT07682441

Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

for Cannabis Use

1 site in Lexington

Sponsor: Hannah Harris

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07694466·EARLY_Phase 1

Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid

for Tobacco Use Cessation

1 site in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07694492

Daridorexant for People With Insomnia and Alcohol Use Disorder Study

for Alcohol Use Disorder

1 site in Spokane

Sponsor: Sterling McPherson

Sex: All·Age: 18+

Code: NCT07701928·Phase 2

Evaluation of Clinical Decision Support in Opioid Tapering

for Medication Abuse

Sponsor: University of Colorado, Denver

Sex: All·Age: 12 - 89·Accepts healthy volunteers

Code: NCT06527079

Addiction medicine clinical trials — common questions

Are addiction medicine clinical trials free to join?

Yes. Participating in a addiction medicine clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a addiction medicine clinical trial?

Each addiction medicine study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a addiction medicine trial near me?

Use the location controls above. We'll show recruiting addiction medicine trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many addiction medicine trials are recruiting right now?

We're currently tracking roughly 812 recruiting addiction medicine trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Addiction medicine trials by city

Boston, MA San Francisco, CA Chicago, IL Indianapolis, IN Los Angeles, CA Birmingham, AL Columbus, OH Seattle, WA Ann Arbor, MI Aurora, CO Oklahoma City, OK San Diego, CA

Conditions in this area

Opioid use disorder Alcohol use disorder Cannabis use / cannabis use disorder Tobacco / nicotine use Substance use disorder