Addiction medicine Clinical Trials

Recruiting addiction medicine studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat addiction medicine. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting addiction medicine studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting addiction medicine trials

Within

Dynamic Treatment Regimes for Opioid Use Disorder

for Opioid Use Disorder

1 site in Irvine

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07011758·Phase 2

Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans

for Opioid Use Disorder

1 site in Northport

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06766331

A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver Disease

for Alcohol Use Disorder

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07553377

A Mindfulness-based Intervention for Sexual Assault Survivors

for Alcohol Misuse

1 site in Atlanta

Sponsor: Georgia State University

Sex: All·Age: 18 - 24

Code: NCT07515586

Family-Focused Study to Support Medication for Opioid Use Disorder

for Opioid Use Disorder

2 sites incl. Chicago

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07451197

Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania

for Alcohol Use Disorder

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07475988

Behavioral Pharmacology of THC and Beta-Myrcene

for Cannabis Use

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT05432284·Phase 1

Permanent Supportive Housing Overdose Prevention+ Study

for Overdose

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07214519

TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD)

for Alcohol Use Disorder

1 site in Portland

Sponsor: Washington State University

Sex: All·Age: 18+

Code: NCT07171359

Apply to this trial

A Feasibility and Acceptability Study of a Large Language Model-based Chatbot for Brief Alcohol Intervention Among Emerging Adults

for Alcohol Use Disorder

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 29

Code: NCT07214831

Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT

for Prevention

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT07672457

Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon

for Alcohol Use Disorder

Sponsor: University of Buea

Sex: All·Age: 18+

Code: NCT07677449

Transcranial Magnetic Stimulation for Adolescents and Young Adults With Cannabis Use Disorder

for Cannabis Use

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 15 - 21

Code: NCT07634835

Abstinence Reinforcement Therapy for Veterans Who Smoke Tobacco and Are Experiencing Homelessness

for Tobacco Use Disorder

1 site in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07714200

Healing After Injury to Reduce Opioid Use and Pain Through Preventive Engagement

for Pain

Sponsor: Henry Ford Health System

Sex: All·Age: 18+

Code: NCT07741201

Yuva Sath: A Peer-led Behavioral Intervention to Support Substance Use Treatment and HIV Prevention Among Young People Who Inject Drugs in India

for Hiv

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 29

Code: NCT06510192

ETSF for Latinx Young Adults with Alcohol Use Disorder

for Alcohol Use Disorder (AUD)

Sponsor: Tulane University

Sex: All·Age: 18 - 29

Code: NCT06722690

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

for Substance Use

3 sites incl. Los Angeles

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07409350

Clinician Practice Companion to Address Youth Substance Use

for Substance Use

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 24·Accepts healthy volunteers

Code: NCT07725289

Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea

for Cigarette Smoking

Sponsor: Sung-il Cho

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT07755891

Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder

for Opioid Use Disorder

2 sites in Pittsburgh

Sponsor: Payel Roy

Sex: All·Age: 22 - 70

Code: NCT07770555

Substance Use in Pregnancy - Optimizing Retention in Treatment by Maximizing Opportunities for Management

for Pregnancy

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: Female·Age: 18+

Code: NCT07776457·Phase 2

Improving HIV Prevention and Substance Use Post-Sexual Assault Services

for HIV Infections

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 17 - 25

Code: NCT07225062

Addressing Parental Tobacco Use in Somali Immigrant Families: Adapting an Evidence-Based Intervention in Primary Care

for Smoking

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06839729·Phase 1

Daridorexant for Alcohol Use Disorder

for Alcohol Use Disorder

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT07532252·Phase 2

Pomegranate Dietary Supplements in AUD and ALD

for Alcohol Use Disorder

1 site in Louisville

Sponsor: University of Louisville

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07678567

Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders

for Alcohol Use Disorder (AUD)

Sponsor: University of Pittsburgh

Sex: Male·Age: 18 - 59

Code: NCT06652802

Chatbot for Online Support Groups to Treat Tobacco Addiction

for Tobacco Dependence

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06952725

Testing a Music Listening mHealth Intervention for Stress Reduction in Early Recovery (CalmiFy II)

for Alcohol Use Disorder (AUD)

Sponsor: Washington State University

Sex: All·Age: 18 - 35

Code: NCT07088237

Evaluating a Digital Toolkit for IPV

for Opioid Use Disorder

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07600307

Lemborexant for Cannabis Use Disorder

for Cannabis Use Disorder

Sponsor: University of Calgary

Sex: All·Age: 18 - 65

Code: NCT07802990·Phase 1, Phase 2

Trial of Tirzepatide for the Treatment of Cannabis Use Disorder

for Cannabis Use Disorder

Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All·Age: 18 - 70

Code: NCT07468552·Phase 2

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

for Opioid Use Disorder

4 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07361432·Phase 3

GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease

for Adiposity

Sponsor: Insel Gruppe AG, University Hospital Bern

Sex: All·Age: 18 - 80

Code: NCT06546384

OEA for Young Adults With Alcohol Use Disorder

for Alcohol Use Disorder (AUD)

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 25

Code: NCT07503782·Phase 2

Effects of Pharmacological Stress and rTMS on Executive Function in Opioid Use Disorder

for Opioid Use Disorder

1 site in Detroit

Sponsor: Wayne State University

Sex: All·Age: 21 - 60

Code: NCT04231708·Phase 2

Opioid Dispenser for Microdiscectomy/Laminectomy

for Opioid Use

1 site in New York

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 18+

Code: NCT06358040

Apply to this trial

Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial

for Opioid Use Disorder

1 site in The Bronx

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT07148206·Phase 3

Methylphenidate and Response to Alcohol Cues

for Alcohol Use Disorder

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 25·Accepts healthy volunteers

Code: NCT07306078·Phase 2

Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation

for Drug Discontinuation

1 site in Dallas

Sponsor: The University of Texas at Dallas

Sex: All·Age: 18 - 70

Code: NCT07387796

Apply to this trial

Examining Analgesic Synergy and Efficacy in Trauma Care

for Opioid Use Disorder

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT07435077·Phase 4

Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors

for Survivors of Childhood Cancer

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 15+

Code: NCT07516301

Apply to this trial

THCV Treatment for Smokers

for Tobacco Use Disorder

Sponsor: University of California, Los Angeles

Sex: All·Age: 21 - 65

Code: NCT07636356·Phase 2

Preventing Overdose and Promoting Recovery Through Court Navigation

for Substance Use Disorder (SUD)

2 sites incl. South Bend

Sponsor: RTI International

Sex: All·Age: 18 - 100

Code: NCT07700407

Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder

for Alcohol Use Disorder (AUD)

2 sites incl. Dallas

Sponsor: Sherwood Brown, MD, PhD

Sex: All·Age: 21 - 55

Code: NCT07734701·Phase 2

Reducing Cardiovascular Risks: The Role of Alcohol Use

for Alcohol Drinking

1 site in Arlington

Sponsor: The University of Texas at Arlington

Sex: All·Age: 26 - 49

Code: NCT07783061

Sensory and Physical Reactions to Beverage Cues

for Alcohol Use Disorder (AUD)

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 21 - 70

Code: NCT07788716

Apply to this trial

Implementing a Digital Alcohol Intervention to Raise Women's Awareness of Alcohol-related Breast Cancer Risk During Routine Screening Visits

for Breast Cancer

1 site in Miami

Sponsor: University of Miami

Sex: Female·Age: 40+

Code: NCT07799467

Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance

for Cannabis Use

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06351540·Phase 1

Developing and Testing an Online Intervention for Alcohol and Cannabis Misuse and Healthy Relationship Skills Among Young Adult Couples

for Alcohol Drinking

Sponsor: University of Washington

Sex: All·Age: 18 - 29·Accepts healthy volunteers

Code: NCT06422299

Mindfulness-Based Substance Use Prevention (MINDS-UP)

for Substance Use

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 10 - 14·Accepts healthy volunteers

Code: NCT06593470

ChatGPT-Supported Text Messaging Program for Smoking Cessation

for Smoking Cessation

1 site in Washington D.C.

Sponsor: George Washington University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07079306

Development of an Opioid Withdrawal Clinical Outcome Assessment

for Opioid Use Disorder

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT07094672

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

for Homelessness

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07141394

Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving

for Alcohol Use Disorder (AUD)

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 21 - 65

Code: NCT07148843·Phase 2, Phase 3

Facilitation to Increase Tobacco Treatment

for Serious Mental Illness

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07455526

Improving Hospital-To-Methadone Clinic Connection Using Implementation Support for Patients With Opioid Use Disorder

for Opioid Use Disorder

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07568847

Development of a Mobile Health Intervention to Support Functioning of Veterans With Substance Use Disorders

for Substance Use

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07645131

Cannabis and Opioid Use Disorder, Study 2

for Opioid Use Disorders

1 site in Lexington

Sponsor: University of Kentucky

Sex: All·Age: 18 - 55

Code: NCT07661446·Phase 1

Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis

for Cannabis Use

1 site in Lexington

Sponsor: Hannah Harris

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07694466·EARLY_Phase 1

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Addiction medicine clinical trials — common questions

Are addiction medicine clinical trials free to join?

Yes. Participating in a addiction medicine clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a addiction medicine clinical trial?

Each addiction medicine study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a addiction medicine trial near me?

Use the location controls above. We'll show recruiting addiction medicine trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many addiction medicine trials are recruiting right now?

We're currently tracking roughly 812 recruiting addiction medicine trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Addiction medicine trials by city

Boston, MA San Francisco, CA Chicago, IL Indianapolis, IN Los Angeles, CA Birmingham, AL Columbus, OH Ann Arbor, MI Oklahoma City, OK Aurora, CO Seattle, WA Detroit, MI

Conditions in this area

Opioid use disorder Alcohol use disorder Cannabis use / cannabis use disorder Tobacco / nicotine use Substance use disorder