Substance use disorder Clinical Trials

Recruiting substance use disorder studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat substance use disorder. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting substance use disorder studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting substance use disorder trials

Within

Permanent Supportive Housing Overdose Prevention+ Study

for Overdose

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07214519

Substance Use Prevention for Recently Displaced Adults - SUPRA (R33) RCT

for Prevention

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT07672457

Yuva Sath: A Peer-led Behavioral Intervention to Support Substance Use Treatment and HIV Prevention Among Young People Who Inject Drugs in India

for Hiv

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 29

Code: NCT06510192

A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs

for Substance Use

3 sites incl. Los Angeles

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07409350

Improving HIV Prevention and Substance Use Post-Sexual Assault Services

for HIV Infections

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 17 - 25

Code: NCT07225062

Preventing Overdose and Promoting Recovery Through Court Navigation

for Substance Use Disorder (SUD)

2 sites incl. South Bend

Sponsor: RTI International

Sex: All·Age: 18 - 100

Code: NCT07700407

Mindfulness-Based Substance Use Prevention (MINDS-UP)

for Substance Use

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 10 - 14·Accepts healthy volunteers

Code: NCT06593470

Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing

for Homelessness

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07141394

Development of a Mobile Health Intervention to Support Functioning of Veterans With Substance Use Disorders

for Substance Use

1 site in West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07645131

Emotion Regulation Program for Substance Use Disorders

for Substance Use Disorder (SUD)

Sponsor: The Catholic University of Korea

Sex: All·Age: 19 - 65

Code: NCT07698821

Pilot Study of an Adapted Partner Navigation Intervention Booster Session for Sustained Healthcare Engagement Among People Who Inject Drugs

for HEPATITIS C (HCV)

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07631559

LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School

for Substance-related Disorders

Sponsor: Prevention Strategies, LLC

Sex: All·Age: 15 - 21·Accepts healthy volunteers

Code: NCT07655609

CBITS-RTM Pilot Study

for PTSD - Post Traumatic Stress Disorder

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 13+

Code: NCT07682441

Craving Management Program for Substance Use Disorders

for Substance Use Disorder (SUD)

Sponsor: The Catholic University of Korea

Sex: All·Age: 19 - 65

Code: NCT07698808

Interprofessional Simulation Program for Clinical Resilience and Empathy: Project INSPIRE

for Substance Use Disorders

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT07707115

Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

for Treatment Resistant Depression

2 sites in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18 - 70

Code: NCT07499583·Phase 1, Phase 2

Supporting Treatment Access and Recovery in Re-entry (STAR-R)

for Mental Health

2 sites incl. Northampton

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT07555145

Combining Social Network Strategies and Routine Substance Use Screening

for HIV

1 site in Chicago

Sponsor: University of California, San Diego

Sex: Male·Age: 18+

Code: NCT07414459

Feasibility of Incorporating a Standardized Substance Use Measure With Linked-Brief Intervention Into Routine Psychosocial Care of Adult Childhood Cancer Survivors

for Survivors of Childhood Cancer

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 15+

Code: NCT07516301

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Justice Community Overdose Innovation Network II TCU Hub

for Substance Use Disorder (SUD)

1 site in Fort Worth

Sponsor: Texas Christian University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07528846

Safety and Feasibility of Next-Generation Dome Helmet (NGDH) for Focused Ultrasound Neuromodulation in Substance Use Disorder (SUD)

for Substance Use Disorder (SUD)

Sponsor: Sunnybrook Health Sciences Centre

Sex: All·Age: 18 - 70

Code: NCT07684976

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Testing and Evaluation of the Returning to the Land Intervention to Address and Prevent Substance Misuse

for Substance Use

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 14 - 19

Code: NCT07695818

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

for Alcoholism

1 site in Baltimore

Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All·Age: 18 - 120

Code: NCT06676059

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Research Investigating Drug Effects-2 (RiDE-2)

for Cannabis Use

1 site in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 21·Accepts healthy volunteers

Code: NCT06758596·EARLY_Phase 1

Engaging Family Members During Early SUD Treatment: A Hybrid Trial

for Substance Use Disorder (SUD)

1 site in San Diego

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07579299

Anabolic-Androgenic Steroid Use Among Gym-Goers

for Anabolic Androgenic Steroid Use

Sponsor: Alaa Yousif Ayed Ahmed

Sex: Male·Age: 18 - 60

Code: NCT07702110

Enhancing Addiction Treatment Through Psychoeducation

for Substance Use Disorders

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18 - 65

Code: NCT07178158

Unified Junction of Care, Integrated Treatments and Team Coordination for ADHD in Prison Settings With Substance Use Disorder

for Attention Deficit Disorder With Hyperactivity (ADHD)

Sponsor: University Hospital, Brest

Sex: All·Age: 18+

Code: NCT07487155

Recovery Inspired Support Engagement (RISE) Pilot

for Support Persons

Sponsor: Mclean Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07519759

mHealth Service Linkage for Young Adults Impacted by the Criminal Legal System

for HIV Prevention

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 29·Accepts healthy volunteers

Code: NCT07599722

The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder

for Tiletamine Use Disorder

Sponsor: Shanghai Mental Health Center

Sex: All·Age: 18 - 60

Code: NCT07689981

Impact of Federal and State Medications for Opioid Use Disorder (MOUD) Policy Changes During the Pandemic

for Substance Use Disorders

1 site in Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT07232641

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Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation

for Drug Discontinuation

1 site in Dallas

Sponsor: The University of Texas at Dallas

Sex: All·Age: 18 - 70

Code: NCT07387796

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Mechanisms of Written Exposure Therapy in Residential SUD Treatment

for PTSD - Post Traumatic Stress Disorder

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 55

Code: NCT07397507

Linking Individuals Needing Care for Substance Use Disorders to Peer Coaches & Across INcarceration Settings

for Substance Use

3 sites incl. Atlanta

Sponsor: Emory University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07563517

First Step Program for Substance Use Disorders

for Substance Use Disorder (SUD)

Sponsor: The Catholic University of Korea

Sex: All·Age: 19 - 65

Code: NCT07658963

The Effect of Comorbid Alcohol/Substance Use

for Alcohol Abuse

Sponsor: Abant Izzet Baysal University

Sex: All·Age: 18 - 65

Code: NCT07692984

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Neuroimaging of Adolescent Cannabis Use Treatment

for Cannabis Use

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 14 - 17

Code: NCT07340554

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Feasibility of an Interdisciplinary Intervention to Improve Care Transitions for Hospitalized Patients With Substance Use Disorders

for Substance Use Disorders

1 site in Salt Lake City

Sponsor: Michael Incze

Sex: All·Age: 18+

Code: NCT07575373

Home Visitation Enhancing Linkages Project in Kansas

for Substance Use

Sponsor: The National Center on Addiction and Substance Abuse at Columbia University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06624332

Reducing Parental Substance Use and Enhancing Family Resilience Among Rural Families Through Ohio START

for Substance Use Disorder (SUD)

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT07278427

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Dynamic Multilevel Processes of Recovery in Therapeutic Communities in Mexico (DICO Model)

for Substance Use Disorder (SUD)

Sponsor: Under The Tree Therapeutic Community

Sex: Male·Age: 18+

Code: NCT07588516

Project REACH: A Comprehensive Telehealth Intervention at Syringe Service Programs to Engage People Who Use Drugs

for Substance Use

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07433712

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Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use

for Opioid Use

1 site in Houston

Sponsor: Christopher D. Verrico

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07218549·Phase 1

Peer-Delivered Behavioral Activation in a CCBHC

for Major Depressive Disorder

1 site in Detroit

Sponsor: Wayne State University

Sex: All·Age: 18+

Code: NCT07219394

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A Study to Investigate Health Related Quality of Life With a Pharmacist Intervention Compared to Treatment as Usual in Participants With Severe Mental Illness and Substance Use Disorder Receiving Treatment From FACT Teams.

for Severe Mental Illness

Sponsor: Sykehuset Innlandet HF

Sex: All·Age: 18+

Code: NCT07597863

Evaluation of the ADD'Pro Vocational Reintegration Program (ADD-PRO-EVAL)

for Addiction

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 16 - 70

Code: NCT07520617

Implementation of TBI-RECOVER in Substance Use Treatment

for Traumatic Brain Injury

1 site in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT07215221

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Pre-Pilot WINGS+++: mHealth to Improve MOUD Uptake in Women Experiencing Intimate Partner Violence and PTSD

for Opioid-Related Disorders

2 sites incl. New York

Sponsor: Dawn A. Goddard-Eckrich

Sex: Female·Age: 18+

Code: NCT07665502

The Trans-Led Care Study

for Substance Abuse

1 site in Chicago

Sponsor: Illinois Institute of Technology

Sex: All·Age: 18+

Code: NCT06880705

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Prevention of Relapse in Behavioral Disorders

for Substance-related Disorders

Sponsor: Clínica Nuestra Señora de la Paz

Sex: All·Age: 18 - 90

Code: NCT07052175

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Efficacy of Digital Problem Solving Application in Reduction of Anxiety, Depression and Substance Use Disorder Symptoms

for Anxiety

Sponsor: 7 Generation Games

Sex: All·Age: 18 - 50

Code: NCT06346431·EARLY_Phase 1

Assessments of Obsessive-compulsive Symptoms in Patients With Substances Use Disorder

for Obsessive - Compulsive Disorder

Sponsor: Assiut University

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07395453

Finding Emotional Empowerment and Lifelong Strength

for Trauma and Stressor Related Disorders

1 site in Piscataway

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07378254

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Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services

for Language Delay

1 site in Eugene

Sponsor: University of Oregon

Sex: All·Age: 18+

Code: NCT07529327

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Incentives and Long-Acting Injectable Adherence After Involuntary Hospitalization

for Schizophrenia Disorder

5 sites in Pittsburgh

Sponsor: Stanford University

Sex: All·Age: 18 - 65

Code: NCT07130500

Adolescent Stress and Substance Intervention Subsequent to Trauma

for PTSD

1 site in Providence

Sponsor: Rhode Island Hospital

Sex: All·Age: 12 - 17·Accepts healthy volunteers

Code: NCT07197476

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Options for Navigating Talking About Risk and Adolescent Choices

for Substance Use (Drugs, Alcohol)

Sponsor: Rhode Island Hospital

Sex: All·Age: 12 - 15·Accepts healthy volunteers

Code: NCT06754527

Transcranial Direct Current Stimulation (tDCS) for Treatment of Cocaine Use Disorder

for Cocaine Use Disorder

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18 - 60

Code: NCT07318480

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Correctional Service of Canada Pilot Trial of Digital Substance Use Disorder Interventions (PROCESS)

for Substance Use Disorder (SUD)

Sponsor: St. Joseph's Healthcare Hamilton

Sex: All·Age: 18 - 55

Code: NCT07342218

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Substance use disorder clinical trials — common questions

Are substance use disorder clinical trials free to join?

Yes. Participating in a substance use disorder clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a substance use disorder clinical trial?

Each substance use disorder study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a substance use disorder trial near me?

Use the location controls above. We'll show recruiting substance use disorder trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many substance use disorder trials are recruiting right now?

We're currently tracking roughly 132 recruiting substance use disorder trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Substance use disorder trials by city

Boston, MA Indianapolis, IN San Francisco, CA Chicago, IL San Diego, CA Birmingham, AL Columbus, OH Eugene, OR Little Rock, AR Los Angeles, CA Oklahoma City, OK Salt Lake City, UT

Related specialties

Behavioral health Addiction medicine