Huntington's Disease and Pain

Sponsor
Leiden University Medical Center
Study ID
NCT06693466
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Facial expression block — OTHER
    Data will be collected to assess the facial expression, body movements and vocalization of (non-) painful heat stimuli. The experiment includes individually tailored and randomly administered painful (perceived as moderate pain) and non-painful heat stimuli.
  • Conditioned pain modulation block — OTHER
    The conditioned pain modulation will be tested according to internationally agreed standards and includes a painful phasic heat (test stimulus) and a painful tonic cold stimulus (conditioning stimulus).
  • Pain facilitation block — OTHER
    Pain facilitation will be assessed by using painful mechanical pinprick stimuli. The magnitude of pain experienced after a single mechanical pinprick stimulus is compared to that of a train of 10 pinprick stimuli of the same force.

Study Details

The primary objective of this pilot study is to assess the feasibility of three internationally agreed pain test batteries in patients with Huntington Disease. The pain test batteries are developed to collect data about the facial expression of pain, body movements and vocalization of (non-) painful stimuli, and to collect data for testing the pain inhibition and facilitation. The study population will include 20 patients with genetically confirmed, adult-onset HD, in stage 1 (n=10) and stages 2 - 3 of HD (n = 10).

Key Dates

First listed
Nov 18, 2024
Start date
Jan 31, 2025
Status verified
Nov 2024
Primary completion
Dec 31, 2025
Completion
Jul 31, 2026

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Adult-onset HD stage 1
    The adult-onset HD stage 1 group (total function capacity 11-13) include 10 participants. The subjects will be undergo three different pain test batteries .
  • Arm: Adult-onset HD stage 2-3
    The adult-onset HD stage 2-3 group (total function capacity 3-10) include 10 participants. The subjects will be undergo three different pain test batteries .

Primary Outcome Measure

The feasibility of a comprehensive experimental design including three different experimental pain protocols in patients with Huntington's Disease [ Time Frame: Baseline assessment ]

Central Contacts

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