Stroke Cerebral Reorganization Pathways (SPECTRE)

Sponsor
Rennes University Hospital
Study ID
NCT06784518
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Clinical scores and functional MRI — OTHER
    Motor evoked potentials between Day 3-Day 7 of the stroke, for a equal distribution of patients into three prognostic groups according to the PREP2 algorithm (good, limited and poor). Longitudinal follow-up with clinical scores and functional MRI at Day 7-Day 10, Day 30, Month 3 and Month 6 of stroke.

Study Details

SPECTRE is a prospective longitudinal study in order to identify whether patients with different degrees of motor recovery are distinguished by distinct brain post-stroke plasticity patterns in the acute and sub-acute phases. This study allows close longitudinal follow-up of patients with severe clinical motor impairment using functional MRI to study cerebral neuroplasticity after ischemic stroke in the acute and sub-acute phase in patients with upper limb motor impairement, taking into account prognostic criteria used in current practice.

Key Dates

First listed
Jan 20, 2025
Start date
Sep 1, 2026
Status verified
Mar 2026
Primary completion
Mar 1, 2029
Completion
Mar 31, 2029

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Patients
    Three prognostic groups according to the PREP2 algorithm (good, limited and poor). 21 evaluable patients divided into 3 balanced prognostic groups.

Primary Outcome Measure

Changes in effective connectivity of Brain data (fMRI activity and CST tractography) [ Time Frame: 6 months ]

Central Contacts

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