Investigating the Neural Signature of Freezing of Gait in Parkinson's Disease

Sponsor
KU Leuven
Study ID
NCT06841718
Status
Enrolling By Invitation

Conditions

  • Basal Ganglia Diseases
  • Brain Disease
  • Freezing of Gait
  • Movement Disorders
  • Neurodegenerative Disease
  • Parkinson Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Freezing of Gait (FOG) is a disabling symptom of Parkinson's disease (PD) and a leading cause for falls. Current medical management is inadequate to alleviate FOG so there is need for improved treatments. A major draw-back in the development of better treatments for FOG is the difficulty in detecting episodes and our poor understanding of its underlying pathophysiology. This study will investigate the cortical signature of FOG using ambulatory electroencephalography (EEG) to help improve FOG detection algorithms and provide novel insights into the underlying pathophysiology, which together will guide therapy development.

Key Dates

First listed
Feb 24, 2025
Start date
Nov 4, 2024
Status verified
Feb 2025
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
28 participants (estimated)

Arms

  • Arm: Home assessment
    All 28 participants will undergo a single home based assessment including a gait protocol as well as administering clinimetrics and questionnaires. Patients will be tested early in the morning after at least 12 hours without the anti-parkinsonian medication (= 'partial' OFF medication) and then about 1 hour after the intake of the first morning medication dose, when the subject reports reaching self-reported ON state (= ON medication). The gait protocol consist out of A) a trajectory in the participants home from the living room towards the bathroom and back, including a 360° turn as well as a figure-8 turn and going through a doorway and B) a daily living task. All tests will be conducted in a fixed order. The protocol will be conducted as a single task, with a dual task (serial subtraction task), with voluntary stops during different parts of the trajectory, and with an auditory cue (rhythm set 10% slower then typical cadence).

Primary Outcome Measure

Power spectral density (Watts/hertz) of beta frequencies [ Time Frame: During walking protocol (duration 15-20 minutes) ]

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