Characteristics of Papez Loop Neural Network in T2DM （Type 2 Diabetes Mellitus）

Sponsor
Nanjing First Hospital, Nanjing Medical University
Study ID
NCT06912321
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
45 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • No Intervention: Observational Cohort — OTHER
    No intervention：all participants did not receive any intervention measures throughout the study

Study Details

This is a cross-sectional and longitudinal study to investigate the characteristic changes in Papez's circuit neural network activity and connectivity based on multimodal MRI, and through follow-up study of the interaction between the internal brain regions of Papez circuit and the function of the external neural network, a prediction model of the characteristic changes of Papez circuit neural network was constructed based on machine learning technology.

Key Dates

First listed
Apr 4, 2025
Start date
May 1, 2024
Status verified
Feb 2025
Primary completion
May 1, 2030
Completion
Dec 31, 2030

Study Design

Enrollment
400 participants (estimated)

Arms

  • Arm: Type 2 Diabetes
    These patients must have a definite diagnosis of type 2 diabetes mellitus (T2DM) according to the American Diabetes Association (ADA) standards
  • Arm: Healthy control
    These participants have normal glucose tolerance and normal cognition

Primary Outcome Measure

Baseline brain structural MRI scan [ Time Frame: Within 1 week after neuropsychological tests ]

Central Contacts

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