Metabolic health Clinical Trials

Recruiting metabolic health studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat metabolic health. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting metabolic health studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting metabolic health trials

Within

MEDBRIDGE-Guided NCM/CHW Post-Discharge Support for High-Risk T2D Patients

for Type 2 Diabetes

2 sites in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07599852

Adiposity Distribution in Acute Respiratory Failure

for Acute Hypoxemic Respiratory Failure

1 site in Boston

Sponsor: Maurizio F. Cereda, MD

Sex: All·Age: 18 - 80

Code: NCT07019987

Liver Steatosis in Pediatric CD Patients

for Celiac Disease in Children

Sponsor: University of Palermo

Sex: All·Age: 1 - 14

Code: NCT06206616

Apply to this trial

Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes

for Gestational Diabetes Mellitus (GDM)

1 site in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18 - 65

Code: NCT07797036·Phase 2, Phase 3

South Asians With Type 2 Diabetes at Risk for Depression

for Type 2 Diabetes

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 75

Code: NCT07219667

SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 site in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 12 - 20

Code: NCT03867487·Phase 2

Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation

for Hypertension (HTN)

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07536919

Simplifying Diet Tracking in a Digital Weight Loss Intervention

for Overweight

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07601061

Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose

for Nutrition, Healthy

1 site in Athens

Sponsor: University of Georgia

Sex: All·Age: 25 - 75·Accepts healthy volunteers

Code: NCT07696403

Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

for Obesity & Overweight

Sponsor: Knut Mai

Sex: All·Age: 18 - 70

Code: NCT07711548

Adaptive Dietary Intervention (ADI) for Asian Americans With Type 2 Diabetes

for Type 2 Diabetes

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07278531

Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults

for Obesity & Overweight

Sponsor: Lumos Pharma

Sex: All·Age: 60 - 84

Code: NCT07754045·Phase 2

SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer

for Endometrial Cancer

Sponsor: Hospital Universitari de Bellvitge

Sex: Female·Age: 18+

Code: NCT07462663·Phase 4

Nutrition Intervention Optimization to Better Utilize Resources and Support Health

for Diabete Type 2

1 site in Dallas

Sponsor: Tufts University

Sex: All·Age: 18+

Code: NCT07713836

Insulin Icodec Initiation Strategies and Day-4 Supplemental Dosing in Type 2 Diabetes

for Type 2 Diabetes

Sponsor: Xi'an International Medical Center Hospital

Sex: All·Age: 18+

Code: NCT07747402·Phase 4

Chrono-Fasting in Overweight and Obese Adolescents

for Obesity

Sponsor: University of Thessaly

Sex: All·Age: 12 - 18

Code: NCT07759414

AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight

for Obesity

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07668401·Phase 3

Target Physiotherapy Versus Exercise Support Intervention for Bladder-bowel Dysfunction in Adolescents With Obesity

for Bladder-Bowel Dysfunction

Sponsor: University of Lisbon

Sex: All·Age: 13 - 18

Code: NCT07724158

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

Digitally Enhanced Cognitive-Behavioral Therapy

for Depression in Adolescence

1 site in Aurora

Sponsor: Colorado State University

Sex: All·Age: 12 - 17

Code: NCT07569991

The Simplified Total-body Resistance Exercise for Muscular Hypertrophy for Diabetic Population (D-STORM)

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Universiti Teknologi Mara

Sex: All·Age: 18 - 65

Code: NCT07664501

GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry

for Heart Failure With Preserved Ejection Fraction

Sponsor: Miedziowe Centrum Zdrowia SA

Sex: All·Age: 18+

Code: NCT07787936

Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity

for Type 1 Diabetes Mellitus

Sponsor: Royal North Shore Hospital

Sex: All·Age: 18 - 70

Code: NCT06180616·Phase 2

A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health Problems

for Obesity

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07790861·Phase 3

Digital Self-Management Education and Support for Young Adults With Type 2 Diabetes (DSMESYAT2DM)

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Recep Turan

Sex: All·Age: 18 - 45

Code: NCT07325838

Effect of a Mobile App for Obese Children on Eating Attitudes, Eating Awareness, and Healthy Eating Self-Efficacy

for Obesity

Sponsor: Cumhuriyet University

Sex: All·Age: 8 - 10

Code: NCT07289425

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

for Cardiovascular Diseases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06320951·Phase 2

Effects of Vibration-Assisted Physical Activity in Type-2 Diabetes

for Diabetes Mellitus, Type 2

Sponsor: University of Central Lancashire

Sex: All·Age: 18 - 65

Code: NCT07350473

HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide

for Type 2 Diabetes Mellitus (T2DM)

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 65 - 85

Code: NCT07760948·Phase 2

Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome

for Schizophrenia Disorder

Sponsor: All India Institute of Medical Sciences, Bhubaneswar

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07770282·Phase 3

Study on Improving Blood Glucose Homeostasis With Dorzagliatin Tablets in the Treatment of Type 2 Diabetes Mellitus Patients With Moderate to Severe Chronic Renal Insufficiency

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 80

Code: NCT07786571

Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy

for Painful Diabetic Neuropathy (PDN)

Sponsor: Wah Medical college , POF hospital

Sex: All·Age: 30 - 70

Code: NCT07800468·Phase 4

Efficacy of the Use of Real-time Continuous Glucose Monitoring on Glycemic Control in Patients With Type 2 Diabetes and Stage 3 and 4 Chronic Kidney Disease.

for Type 2 Diabetes

Sponsor: Hospital Universitario San Ignacio

Sex: All·Age: 18+

Code: NCT07668219

Effect of Molar Replacement on Glycemic Control in Adults With Uncontrolled Type 2 Diabetes

for Type 2 Diabetes

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 75

Code: NCT07666529

Obesity and Oral Diseases in Adult Patients

for Obesity

Sponsor: University of Bergen

Sex: All·Age: 20 - 70

Code: NCT04602572

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

for Weight Loss

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07535892

Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals

for Obesity

Sponsor: Acibadem University

Sex: All·Age: 18 - 65

Code: NCT07609160

Switching to Oral Weight Management Pharmacotherapy to Prevent Weight Regain After GLP-1 Therapy Discontinuation

for Obesity

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT07729332·Phase 4

Mazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer

for Obesity

Sponsor: Tongji Hospital

Sex: Female·Age: 18 - 45

Code: NCT07781150·Phase 2

Digital Resistance Training for Midlife Women Using GLP-1

for Women's Health

1 site in Baton Rouge

Sponsor: Louisiana State University and A&M College

Sex: Female·Age: 40 - 59

Code: NCT07787533

Incisionless Suture Plications in a POSE2.0 Obesity Study

for Obesity

Sponsor: USGI Medical

Sex: All·Age: 22 - 65

Code: NCT06272201

Theoretically Informed Behavioral Intervention

for HIV

1 site in Orange

Sponsor: Yale University

Sex: Male·Age: 18+

Code: NCT06580184

Inhaled Nitric Oxide in Severe Obesity

for Obesity

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06675435

Vibegron for ENergy Thinking and Resilience in Aging

for Obesity

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 45 - 75

Code: NCT06987383·Phase 3

Experience With the Use of Continuous Glucose Monitoring (CGM) Devices in People With Type 2 Diabetes Mellitus

for Patient Satisfaction

Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina

Sex: All·Age: 18+

Code: NCT07019753

Associations Between Dietary Patterns, LDL Aggregation, and Cardiometabolic Health

for Atherosclerosis Cardiovascular Disease

Sponsor: Liverpool John Moores University

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT07474233

PLAY2CONTROL Study

for Type 2 Diabetes

1 site in Miami

Sponsor: University of Miami

Sex: All·Age: 5 - 21

Code: NCT07556679

Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

for Obesity (BMI>30)

1 site in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07653464·EARLY_Phase 1

Phase II Study of Switching From Dulaglutide to PG-102(MG12) in Type 2 Diabetes Mellitus

for Type 2 Diabetes

Sponsor: ProGen. Co., Ltd.

Sex: All·Age: 19 - 75

Code: NCT07677891·Phase 2

Blood-based sEV Proteins for Early Detection of 2 Diabetes

for Obesity & Overweight

Sponsor: Hong Kong Baptist University

Sex: All·Age: 40 - 59·Accepts healthy volunteers

Code: NCT07728591

A Study of Macupatide (LY3532226) in Participants With Obesity or Overweight Without Type 2 Diabetes

for Obesity

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07765511·Phase 1

Hypothyroidism and Liver Fibrosis Severity in MASLD

for Metabolic Dysfunction-Associated Steatotic Liver Disease

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793279

Serum Asprosin, Metabolic Syndrome, and Cardiometabolic Risk in Rheumatoid Arthritis

for Rheumatoid Arthritis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07793747

Polydextrose Functional Gummies for Weight Management in Adults With Overweight or Obesity

for Obesity & Overweight

Sponsor: Nutris We Care About You S.L.

Sex: All·Age: 18 - 70

Code: NCT07758387

Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity

for Severe Adolescent Obesity

Sponsor: Fondation Santé des Étudiants de France

Sex: All·Age: 12 - 20

Code: NCT07652190

Study Evaluating the Safety and Feasibility of Endoscopic Duodenal Injections of Autologous Mesenchymal Stem Cells

for Diabete Type 2

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT07344324

Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury

for Metabolic Syndrome

1 site in Gunnison

Sponsor: Gary Van Guilder

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06825143·EARLY_Phase 1

GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward

for Obesity, Childhood

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 12 - 18

Code: NCT06977438·Phase 4

Enhancing Mental and Physical Health of Women Veterans 3.0

for Cardiovascular Diseases

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07356479

"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"

for Diabetes Mellitus, Type 2

Sponsor: Escuela Universitaria de Osuna

Sex: All·Age: 30 - 65

Code: NCT07685080

New trials in Birmingham, AL?

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Metabolic health clinical trials — common questions

Are metabolic health clinical trials free to join?

Yes. Participating in a metabolic health clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a metabolic health clinical trial?

Each metabolic health study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a metabolic health trial near me?

Use the location controls above. We'll show recruiting metabolic health trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many metabolic health trials are recruiting right now?

We're currently tracking roughly 930 recruiting metabolic health trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Metabolic health trials by city

Birmingham, AL Boston, MA Chicago, IL Los Angeles, CA Aurora, CO Miami, FL Ann Arbor, MI Cleveland, OH La Jolla, CA Orlando, FL Palo Alto, CA San Diego, CA

Conditions in this area

Obesity / overweight Type 2 diabetes Insulin resistance Metabolic syndrome Non-alcoholic fatty liver disease (NAFLD)