Weight loss Clinical Trials

Recruiting weight loss studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat weight loss. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting weight loss studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting weight loss trials

Within

MEDBRIDGE-Guided NCM/CHW Post-Discharge Support for High-Risk T2D Patients

for Type 2 Diabetes

2 sites in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07599852

Adiposity Distribution in Acute Respiratory Failure

for Acute Hypoxemic Respiratory Failure

1 site in Boston

Sponsor: Maurizio F. Cereda, MD

Sex: All·Age: 18 - 80

Code: NCT07019987

South Asians With Type 2 Diabetes at Risk for Depression

for Type 2 Diabetes

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 75

Code: NCT07219667

Integrating Care for Hypertension-Diabetes MULTImorbidity in Guatemala Through HEARTS Implementation

for Hypertension (HTN)

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07536919

Simplifying Diet Tracking in a Digital Weight Loss Intervention

for Overweight

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07601061

Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?

for Obesity & Overweight

Sponsor: Knut Mai

Sex: All·Age: 18 - 70

Code: NCT07711548

SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer

for Endometrial Cancer

Sponsor: Hospital Universitari de Bellvitge

Sex: Female·Age: 18+

Code: NCT07462663·Phase 4

Nutrition Intervention Optimization to Better Utilize Resources and Support Health

for Diabete Type 2

1 site in Dallas

Sponsor: Tufts University

Sex: All·Age: 18+

Code: NCT07713836

AMAZE 13: A Research Study Investigating How Well the Medicine Zenagamtide Helps People in Asia With Excess Body Weight Lose Weight

for Obesity

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07668401·Phase 3

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

Digitally Enhanced Cognitive-Behavioral Therapy

for Depression in Adolescence

1 site in Aurora

Sponsor: Colorado State University

Sex: All·Age: 12 - 17

Code: NCT07569991

The Simplified Total-body Resistance Exercise for Muscular Hypertrophy for Diabetic Population (D-STORM)

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Universiti Teknologi Mara

Sex: All·Age: 18 - 65

Code: NCT07664501

Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity

for Type 1 Diabetes Mellitus

Sponsor: Royal North Shore Hospital

Sex: All·Age: 18 - 70

Code: NCT06180616·Phase 2

Effect of a Mobile App for Obese Children on Eating Attitudes, Eating Awareness, and Healthy Eating Self-Efficacy

for Obesity

Sponsor: Cumhuriyet University

Sex: All·Age: 8 - 10

Code: NCT07289425

VITAL-IMPACT: Improving Cardiometabolic Health in Black Individuals Through Therapeutic Augmentation of Cyclic Guanosine Mono-Phosphate Signaling Pathway

for Cardiovascular Diseases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06320951·Phase 2

Effects of Vibration-Assisted Physical Activity in Type-2 Diabetes

for Diabetes Mellitus, Type 2

Sponsor: University of Central Lancashire

Sex: All·Age: 18 - 65

Code: NCT07350473

Efficacy of the Use of Real-time Continuous Glucose Monitoring on Glycemic Control in Patients With Type 2 Diabetes and Stage 3 and 4 Chronic Kidney Disease.

for Type 2 Diabetes

Sponsor: Hospital Universitario San Ignacio

Sex: All·Age: 18+

Code: NCT07668219

Effect of Molar Replacement on Glycemic Control in Adults With Uncontrolled Type 2 Diabetes

for Type 2 Diabetes

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 75

Code: NCT07666529

Obesity and Oral Diseases in Adult Patients

for Obesity

Sponsor: University of Bergen

Sex: All·Age: 20 - 70

Code: NCT04602572

Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation

for Weight Loss

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT07535892

Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals

for Obesity

Sponsor: Acibadem University

Sex: All·Age: 18 - 65

Code: NCT07609160

Incisionless Suture Plications in a POSE2.0 Obesity Study

for Obesity

Sponsor: USGI Medical

Sex: All·Age: 22 - 65

Code: NCT06272201

Theoretically Informed Behavioral Intervention

for HIV

1 site in Orange

Sponsor: Yale University

Sex: Male·Age: 18+

Code: NCT06580184

Inhaled Nitric Oxide in Severe Obesity

for Obesity

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06675435

Phase II Study of Switching From Dulaglutide to PG-102(MG12) in Type 2 Diabetes Mellitus

for Type 2 Diabetes

Sponsor: ProGen. Co., Ltd.

Sex: All·Age: 19 - 75

Code: NCT07677891·Phase 2

Comparison of Day Hospitalization Versus Full-Time Hospitalization in the Treatment of Severe Adolescent Obesity

for Severe Adolescent Obesity

Sponsor: Fondation Santé des Étudiants de France

Sex: All·Age: 12 - 20

Code: NCT07652190

Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion Injury

for Metabolic Syndrome

1 site in Gunnison

Sponsor: Gary Van Guilder

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06825143·EARLY_Phase 1

GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward

for Obesity, Childhood

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 12 - 18

Code: NCT06977438·Phase 4

Enhancing Mental and Physical Health of Women Veterans 3.0

for Cardiovascular Diseases

1 site in West Los Angeles

Sponsor: VA Office of Research and Development

Sex: All·Age: All ages

Code: NCT07356479

"Effectiveness of Supervised and Unsupervised mHealth-based Exercise Interventions on Clinical Outcomes in Adults With Type 2 Diabetes and Obesity Within a Primary Care Context"

for Diabetes Mellitus, Type 2

Sponsor: Escuela Universitaria de Osuna

Sex: All·Age: 30 - 65

Code: NCT07685080

Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, and Cognition in Post-Menopausal Women

for Obesity & Overweight

1 site in Little Rock

Sponsor: University of Arkansas

Sex: Female·Age: 50 - 65·Accepts healthy volunteers

Code: NCT07705724

Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss

for Obesity

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65

Code: NCT06299644

COMPASS 65+ - Community-based Physical Activity Snacks for Healthy Aging in Overweight and Obese Aged Adults

for Obesity & Overweight

Sponsor: University of Coimbra

Sex: All·Age: 65+

Code: NCT07289529

Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud

for Normal Weight Obesity

Sponsor: Pomeranian Medical University Szczecin

Sex: Female·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07358533

Effects of Whole Fruit on Blood Sugar in People With Type 2 Diabetes

for Type 2 Diabetes

1 site in Boston

Sponsor: Harvard School of Public Health (HSPH)

Sex: All·Age: 18+

Code: NCT07376226

Ultrasound Assessment of Tongue Characteristics in Adolescents With Obesity and Obstructive Sleep Disorders

for Obesity & Overweight Sleep

Sponsor: Vrije Universiteit Brussel

Sex: All·Age: 12 - 18·Accepts healthy volunteers

Code: NCT07613944

BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity

for Obesity & Overweight

Sponsor: Carnot Laboratories

Sex: All·Age: 18+

Code: NCT07622810·Phase 3

BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Carnot Laboratories

Sex: All·Age: 18+

Code: NCT07628985·Phase 3

PLEASURE (Pleasing Lovers, Efficacy, Arousal, Satisfaction, and Uptake Research on Eroxon)

for Type 2 Diabetes

1 site in Miami

Sponsor: University of Miami

Sex: Male·Age: 18 - 40

Code: NCT07636161·Phase 4

A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes

for Diabetes Mellitus, Type 2

17 sites incl. Sacramento

Sponsor: Eli Lilly and Company

Sex: All·Age: 10 - 17

Code: NCT07668336·Phase 3

Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 20 - 78

Code: NCT07670871

A Mediterranean Diet-Based Culinary Intervention in Adults With Metabolic Syndrome

for Metabolic Syndrome

Sponsor: Fundacion Clinic per a la Recerca Biomédica

Sex: All·Age: 30 - 60

Code: NCT07702695

A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

for Overweight

46 sites incl. Lancaster

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07668414·Phase 3

A Phase I Study of Single and Multiple Doses of HS-20136-2 Injection in Healthy or Obese Participants

for Obesity

Sponsor: Jiangsu Hansoh Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07716241·Phase 1

Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes

for Obesity

Sponsor: University Hospital, Toulouse

Sex: All·Age: 45 - 70·Accepts healthy volunteers

Code: NCT07075133

Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semaglutide

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Tianjin Medical University

Sex: All·Age: 18 - 60

Code: NCT07713992

Effect of Prebiotics in Saudi Adults With Type 2 Diabetes

for Type 2 Diabetes

Sponsor: Princess Nourah Bint Abdulrahman University

Sex: All·Age: 45 - 60·Accepts healthy volunteers

Code: NCT07464691

Puerto Rican Obesity Intervention for Men

for Obesity

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: Male·Age: 35+·Accepts healthy volunteers

Code: NCT06440551

Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

for Obesity

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07224087·Phase 1

Impact of Lifestyle on Health Maintenance: A Randomized Controlled Trial

for Metabolic Syndrome

Sponsor: University of Zadar

Sex: All·Age: 20+·Accepts healthy volunteers

Code: NCT07314957

A Multiple Health Behavior Change (MHBC) Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients

for Obesity

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT07398404·Phase 1, Phase 2

The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity

for Pre Diabetic

Sponsor: University of Primorska

Sex: All·Age: 18 - 70

Code: NCT07423065

Apply to this trial

Inherited and Environmental Risks Acting on Body Weight

for Genetics

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 20 - 45·Accepts healthy volunteers

Code: NCT07430852

The Role of Autoantibodies Against G-protein Coupled Receptors in Obesity

for Obesity

Sponsor: Claus Bogh Juhl

Sex: All·Age: 18 - 60

Code: NCT07542327

Diet and WB-EMS Effects in Obesity

for Obesity & Overweight

Sponsor: Firat University

Sex: All·Age: 18 - 65

Code: NCT07562724

eHealth Lifestyle Intervention To Enhance Outcomes in HFpEF

for Heart Failure and Preserved Ejection Fraction

Sponsor: Maimónides Biomedical Research Institute of Córdoba

Sex: All·Age: 18+

Code: NCT07661732

Trauma Therapy for Weight-Based Bullying in Children

for Pediatric Obesity

Sponsor: Western University

Sex: All·Age: 10 - 17

Code: NCT07685990

Sleep Evaluation Before and After Metabolic Surgery

for Obesity & Overweight

Sponsor: Catharina Ziekenhuis Eindhoven

Sex: All·Age: 18+

Code: NCT07693491

Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients

for Atrial Fibrillation

Sponsor: Yunlong Wang

Sex: All·Age: 18 - 75

Code: NCT07715929·Phase 4

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

for Overweight

42 sites incl. Anniston

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07720271·Phase 3

Weight loss clinical trials — common questions

Are weight loss clinical trials free to join?

Yes. Participating in a weight loss clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a weight loss clinical trial?

Each weight loss study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a weight loss trial near me?

Use the location controls above. We'll show recruiting weight loss trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many weight loss trials are recruiting right now?

We're currently tracking roughly 867 recruiting weight loss trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Weight loss trials by city

Birmingham, AL Boston, MA Aurora, CO Los Angeles, CA Chicago, IL Ann Arbor, MI Miami, FL Cleveland, OH La Jolla, CA Palo Alto, CA San Diego, CA Milwaukee, WI

Conditions in this area

Obesity / overweight Type 2 diabetes Metabolic syndrome