Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)

Part of paid clinical trials in Richmond, Virginia.

Sponsor
Virginia Commonwealth University
Study ID
NCT07013396
Status
Not Yet Recruiting

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Conditions

  • Acute Ischemic Stroke
  • Anterior Cerebral Artery Stroke
  • Anterior Cerebral Artery Syndrome
  • Cardioembolic Stroke
  • Vasogenic Cerebral Edema

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Doppler (TCD) examination — OTHER
    Serial non-invasive TCD monitoring will be performed as soon as possible after EVT, daily for 72 hours, and when possible, close to any neurological deterioration or head CT obtained within 72 hours after EVT. TCD parameters include PSV, EDV, MFV, and PI measured in bilateral MCA, ACA, PCA, carotid siphon, vertebrobasilar arteries, and ophthalmic artery territories. Collateralization patterns, including ACA flow reversal, ophthalmic artery flow reversal, and high-flow ACA or PCA patterns relative to MCA flow, will also be assessed.

Study Details

Endovascular thrombectomy (EVT) improves outcomes in acute ischemic stroke caused by large vessel occlusion. Despite successful recanalization, early neurological deterioration (END) remains frequent and is associated with poor outcomes. Transcranial Doppler (TCD) provides noninvasive, real-time assessment of cerebral blood flow velocities and may identify hemodynamic patterns associated with deterioration after EVT. PRECISE-TCD is a prospective, single-center observational study enrolling 180-300 patients undergoing EVT for anterior circulation large vessel occlusion at a tertiary academic medical center. Serial TCD examinations are performed immediately after EVT, daily for 72 hours, and as close as possible to early neurological deterioration events or clinically indicated head CT within 72 hours. The primary outcome is the association between TCD-derived hemodynamic parameters and END within 72 hours. Secondary outcomes include NIHSS at 24 hours and discharge, discharge disposition, and modified Rankin Scale at 90 days.

Key Dates

First listed
Jun 10, 2025
Start date
Aug 31, 2026
Status verified
Jul 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Anterior circulation LVO stroke treated with EVT
    Patients with anterior circulation large vessel occlusion, including ACA, MCA, or ICA stroke, with tandem occlusions included, treated with endovascular thrombectomy at VCU Medical Center.

Primary Outcome Measure

Occurrence of early neurological deterioration (END) within 72 hours after EVT [ Time Frame: Within 72 hours after EVT ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Commonwealth UniversityRichmondVirginia23235
Tarun Srivastava
[email protected]
804-828-9499
Aarti Sarwal
[email protected]
Aarti Sarwal (PRINCIPAL_INVESTIGATOR)

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By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Virginia Commonwealth University· Richmond, VA

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