Role of Mitochondrial Bioenergetics in Resilience for Gynecologic Cancer

Conditions

• Gynecologycal Cancer

Eligibility Criteria

Sex

FEMALE

Age

50 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• muscle sample — DIAGNOSTIC_TEST
  For participants undergoing standard of care interval cytoreductive surgery via laparotomy, a skeletal muscle biopsy from the rectus abdominis muscle (1 cm x 1 cm x 1 cm, \~300 mg) will be collected. For participants who undergo standard of care interval cytoreductive surgery with a laparoscopic approach, a skeletal muscle biopsy will be taken from either the rectus abdominis (1 cm x 1 cm x 1 cm, \~300 mg) or the psoas (1 cm x 0.5 cm x 0.5 cm, \~200 mg) muscle.
• blood draw — OTHER
  A total of approximately 60mL or 4 tablespoons of blood will be collected throughout the study

Study Details

The purpose of this research study is to see if patients with endometrial and ovarian cancer are willing to complete physical and cognitive assessments before treatment and again after treatment has ended.

Key Dates

First listed

Jul 2, 2025

Start date

Mar 10, 2026

Status verified

Jul 2026

Primary completion

Apr 30, 2027

Completion

Apr 30, 2027

Study Design

Enrollment

30 participants (estimated)

Arms

• Arm: Advanced gynecological cancers
  Participants 50 years and older with suspected or newly diagnosed advanced gynecological cancer (ovarian/primary peritoneal/fallopian tube or endometrial carcinoma of any histological subtype) who are planned to undergo SOC treatment.

Primary Outcome Measure

Screening rate [ Time Frame: Screening ]

Central Contacts

• Brandy Baker
  (336) 713-8941
  [email protected]

Locations (2)

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