Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

Part of paid clinical trials in New York, New York.

Sponsor: NYU Langone Health
Study ID: NCT07111390
Status: Recruiting

Apply to this trial

Conditions

Depression
MDD
Major Depressive Disorder
Major Depressive Episode

Eligibility Criteria

Sex: ALL
Age: 24 Years - 65 Years
Healthy Volunteers: Not accepted

Interventions

60Hz Intermittent Light Therapy — DEVICE
Intermittent 60 Hz flickering white light delivered via a wearable headset.
Sham Light Therapy — DEVICE
Constant white light delivered via a wearable headset.

Study Details

This pilot study evaluates the feasibility, safety, and preliminary efficacy of home-based 60Hz intermittent light therapy in adults with a major depressive episode (MDE). Participants will be randomized in a 2:1 ratio to receive either active or sham 60Hz intermittent light stimulation for 30 minutes daily (Monday through Friday) over three weeks. The light is delivered through a wearable headset. Clinical assessments will be conducted remotely at baseline, mid-point, post-treatment, and follow-up to measure changes in depressive symptoms.

Key Dates

First listed: Aug 8, 2025
Start date: Aug 18, 2025
Status verified: Jun 2026
Primary completion: Jan 1, 2027
Completion: Feb 1, 2027

Study Design

Enrollment: 40 participants (estimated)
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Arms

Experimental: Active Home-Based Intermittent Light Therapy
Adults with a major depressive episode (MDE) randomized to receive active home-based 60Hz intermittent light therapy, delivered five days per week for three weeks for a total of 15x30-minute daily sessions.
Sham Comparator: Sham Home-Based Light Therapy
Adults with a major depressive episode (MDE) randomized to receive sham home-based light therapy, delivered five days per week for three weeks for a total of 15x30-minute daily sessions.