Depression Clinical Trials

Recruiting depression studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat depression. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting depression studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting depression trials

Within

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Pilot Randomized Trial of BA-GSH in VA PC-MHI

for Depression

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07541482

Prevalence of Depression Among Patients With Alopecia Areata

for Alopecia Areata Depression

Sponsor: Sohag University

Sex: All·Age: 18 - 100

Code: NCT07711574

Mental Health INtervention With Digital APPlications (MIND-APP): Randomized Controlled Researcher Blinded Trial Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps

for Anxiety

Sponsor: University Hospital, Akershus

Sex: All·Age: 16+

Code: NCT07627204

Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks"

for Anxiety

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13 - 24

Code: NCT07539636

Stony Brook Medicine Anti-Inflammatory Trial

for Major Depressive Disorder

Sponsor: Stony Brook University

Sex: All·Age: 18 - 65

Code: NCT06699966·Phase 4

Technology dRiven Enhancement to Engage & Connect

for Depression

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 50 - 80

Code: NCT06910683

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Community Health Worker Implementation of Transdiagnostic Evidence-based Mental Health Intervention for Spanish-speaking Latine Parents

for Depression

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07390630

Benefits of Exergames on Neurocognitive Functions in Adults Suffering From Depression

for Depression

Sponsor: MAP Institute

Sex: All·Age: 18 - 65

Code: NCT06536530

Personalizing Mental Health Treatment for Youth and Families

for Anxiety

Sponsor: University of Oregon

Sex: All·Age: 5 - 15

Code: NCT07425366

Group PACBT for Depression

for Depression - Major Depressive Disorder

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 21 - 60

Code: NCT07566104·Phase 2

A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients

for Major Depressive Disorder

1 site in Los Angeles

Sponsor: BioLite, Inc.

Sex: All·Age: 21 - 85

Code: NCT03833206·Phase 1, Phase 2

Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications

for Schizophrenia

Sponsor: Central South University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07444463

Accelerated iTBS for Depression and Suicidality

for Major Depressive Disorder

Sponsor: University of Iowa

Sex: All·Age: 18 - 90

Code: NCT04441008

Sham-Controlled Rapid-Acting Neuromodulation for Depression

for Depression - Major Depressive Disorder

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18 - 65

Code: NCT07487454

Treatment of Depression Post-SCI

for Depression

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT04263285

Apply to this trial

Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms

for Depression

2 sites incl. Syracuse

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07202325

Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression

for Major Depressive Disorder (MDD)

Sponsor: First Affiliated Hospital of Chongqing Medical University

Sex: All·Age: 12 - 18

Code: NCT07645157·Phase 2

Apply to this trial

Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-

for Depression

Sponsor: University Hospital, Tours

Sex: All·Age: 60+

Code: NCT06382389·Phase 2

Sedation and Guided Education for Depression Study

for Major Depressive Disorder (MDD)

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06705270

Deaf CBT-TS to Reduce Suicide Risk

for Depression - Major Depressive Disorder

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT07279363

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

for Fibromyalgia

Sponsor: Hospital Ambroise Paré Paris

Sex: All·Age: 18 - 80

Code: NCT07642882

Apply to this trial

Pregnenolone for Cannabis Use Disorder and Depression

for Cannabis Use Disorder

2 sites incl. Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 50

Code: NCT07685964·Phase 1, Phase 2

Cognitive Stimulation Program With Virtual Reality for Older Adults With Depressive Symptoms

for Depressive Symptoms

Sponsor: Grupo Lusófona

Sex: All·Age: 65+

Code: NCT07710222

Study on Mental Health Promoting Effects of Natural Psychotherapy for Adolescents

for Anxiety Disorders

Sponsor: Beijing HuiLongGuan Hospital

Sex: All·Age: 7 - 18·Accepts healthy volunteers

Code: NCT07639476

Fasting, Exercise, and Diet to Activate Autophagy in Depression

for Depression - Major Depressive Disorder

Sponsor: University of Zurich

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07664540

AcceXible Speech-Based Screening for Depression and Anxiety in University Students (UAQ, Mexico)

for Depression - Major Depressive Disorder

Sponsor: Accexible

Sex: All·Age: 16 - 25·Accepts healthy volunteers

Code: NCT07578142

Mindfulness in High Risk Pregnancies

for Stress

Sponsor: University of Alberta

Sex: Female·Age: 18+

Code: NCT04496115

PET Biomarker Study for Antidepressant Response Prediction in Major Depressive Disorder

for Major Depressive Disorder

Sponsor: Central Hospital, Nancy, France

Sex: All·Age: 18+

Code: NCT06452290

Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder

for Major Depressive Disorder

Sponsor: Centre Psychothérapique de Nancy

Sex: All·Age: 18+

Code: NCT06532604

Use of Virtual Reality as a Tool for Cognitive Remediation in Elderly Depressed Patients

for Virtual Reality

Sponsor: University Hospital, Brest

Sex: All·Age: 70+

Code: NCT07119008

A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial

for Treatment Resistant Depression

3 sites incl. Sarasota

Sponsor: NeuroRx, Inc.

Sex: All·Age: 18 - 80

Code: NCT07227103·Phase 2, Phase 3

MindfulCityU-- A Mindfulness Mobile Application for Promoting University Students' Mental Health

for Depressive Symptoms

Sponsor: City University of Hong Kong

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT07392632

Cognitive Enhancement in Recurrent Depression (The COG-D-R Study)

for Aging

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 60+

Code: NCT07527273

Examining the Health Effects of NPOWER365 Among Black Same Gender Loving Men

for Sexual and Gender Minorities

Sponsor: Rutgers, The State University of New Jersey

Sex: All·Age: 18+

Code: NCT06315218

Reduction of Depression in People With Disabilities Through Dual Treatment: Digital CBT & NBHWC Coaching

for Hearing Disability

4 sites incl. Dover

Sponsor: Toivoa Inc

Sex: All·Age: 22+

Code: NCT07195292

A Study of a Mental Fitness Intervention for Anesthesiology Resident Wellbeing and Self-Compassion

for Wellness

2 sites in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07639827

Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health.

for Hepatitis B

Sponsor: Eunice Dube

Sex: All·Age: 13 - 45·Accepts healthy volunteers

Code: NCT06786429·Phase 4

Sleep Disturbances and Their Association With Serum Magnesium Level in Patients With Major Depressive Disorder

for Depressive Disorder

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07198477

Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium - Maintenance

for Major Depressive Disorder (MDD)

Sponsor: Motif Neurotech, Inc.

Sex: All·Age: 22 - 85

Code: NCT07684794

Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET)

for Depression

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: All ages

Code: NCT06811454

Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial

for Major Depressive Disorder (MDD)

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 22 - 80

Code: NCT07043738

Multimodal Differences in Effort-based Decision-Making in Depression

for Depression

1 site in Atlanta

Sponsor: Georgia Institute of Technology

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06648460

Efficacy and Safety of Accelerated Intermittent Theta-burst Stimulation (a-iTBS) in Adolescents With Depressive Disorder

for Depression - Major Depressive Disorder

Sponsor: First Affiliated Hospital of Chongqing Medical University

Sex: All·Age: 12 - 18

Code: NCT07369713

Task-Shifting Adapted IPT-A for Youth Suicide Prevention

for Suicidal Ideation

1 site in Chestnut Hill

Sponsor: Boston College

Sex: All·Age: 12 - 17

Code: NCT07383831

Effect of Virtual Reality on Depression in Adolescent Females

for Depression

Sponsor: Cairo University

Sex: Female·Age: 13 - 18

Code: NCT07452341

Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

for Treatment Resistant Depression

2 sites in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18 - 70

Code: NCT07499583·Phase 1, Phase 2

Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis

for Psychosis

1 site in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 50

Code: NCT07503093

Inhaled DMT for Major Depressive Disorder

for MDD

Sponsor: Universidade Federal do Rio Grande do Norte

Sex: All·Age: 18+

Code: NCT07562191·Phase 2

Apply to this trial

Multi-site Feasibility of an Integrated Treatment for the Biology and Experience of Depression: The MULTIBED Study

for Major Depressive Disorder

3 sites incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07596914

Comparing Outcomes of Theta Burst Stimulation in Depression Using Advanced PET Imaging

for Depression

Sponsor: The Royal Ottawa Mental Health Centre

Sex: All·Age: 18 - 55

Code: NCT07620288

The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

for Depression

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT06206226

Online Intervention for Transgender/Nonbinary Young Adults' Experiences With Alcohol and Romantic Relationships

for Alcohol Use, Unspecified

1 site in Boston

Sponsor: Boston University

Sex: All·Age: 18 - 30

Code: NCT06392542

Yoga, Meditation and Mindful Eating Intervention in University Students

for Stress, Psychological

Sponsor: Universidad de Antioquia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07280078

Auditory Stimulation for Insomnia and Depression

for Depression - Major Depressive Disorder

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 20 - 50

Code: NCT07553364

Regulated Stimulation for Optimized Network Activity and Therapeutic Equilibrium

for Major Depressive Disorder

Sponsor: Motif Neurotech, Inc.

Sex: All·Age: 22 - 85

Code: NCT07594483

Assessing the Impact of the Personalized Medicine Clinic on Mental Health Outcomes

for Mental Health

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07601477

The Efficacy of Psilocybin Therapy for Depression in Parkinson's Disease

for Depression

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 40 - 80

Code: NCT07610369·Phase 2

Apply to this trial

Depression clinical trials — common questions

Are depression clinical trials free to join?

Yes. Participating in a depression clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a depression clinical trial?

Each depression study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a depression trial near me?

Use the location controls above. We'll show recruiting depression trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many depression trials are recruiting right now?

We're currently tracking roughly 680 recruiting depression trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Depression trials by city

Boston, MA Los Angeles, CA Chicago, IL San Francisco, CA San Diego, CA Ann Arbor, MI Birmingham, AL Madison, WI Stanford, CA Aurora, CO Miami, FL Palo Alto, CA

Related specialties

Psychiatry Mental health Behavioral health