Depression Clinical Trials

Recruiting depression studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat depression. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting depression studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting depression trials

Within

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

ACT for Veterans With IBD and Mental Health Challenges

for Inflammatory Bowel Diseases

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07397195

Pilot Randomized Trial of BA-GSH in VA PC-MHI

for Depression

1 site in Houston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07541482

Whole Selves User Testing and Feasibility Study

for Alcohol Use, Unspecified

1 site in Boston

Sponsor: Boston University

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06392542

Prevalence of Depression Among Patients With Alopecia Areata

for Alopecia Areata Depression

Sponsor: Sohag University

Sex: All·Age: 18 - 100

Code: NCT07711574

iMORE+ Study: A Multi-Omics Cohort Study of Major Depressive Disorder

for Major Depressive Disorder (MDD)

Sponsor: Shanghai Mental Health Center

Sex: All·Age: 14 - 45·Accepts healthy volunteers

Code: NCT07735143

Mental Health INtervention With Digital APPlications (MIND-APP): Randomized Controlled Researcher Blinded Trial Evaluating the Effectiveness of the Tankevirus and Grubl Mental Health Apps

for Anxiety

Sponsor: University Hospital, Akershus

Sex: All·Age: 16+

Code: NCT07627204

Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks"

for Anxiety

Sponsor: University of Illinois at Chicago

Sex: All·Age: 13 - 24

Code: NCT07539636

Stony Brook Medicine Anti-Inflammatory Trial

for Major Depressive Disorder

Sponsor: Stony Brook University

Sex: All·Age: 18 - 65

Code: NCT06699966·Phase 4

Technology dRiven Enhancement to Engage & Connect

for Depression

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 50 - 80

Code: NCT06910683

Role of Kynurenine Pathway and Its Metabolites in Depressive Disorders, Major Depressive Disorder is Suspected to Have the Greatest Burden by 2030,Kynurenine Pathway is Major Route Through Which the Essential Amino Acid Tryptophan is Metabolised and Activated in Time of Stress and Immune Activation.

for Major Depressive Disorder (MDD)

Sponsor: Sohag University

Sex: All·Age: 18 - 18·Accepts healthy volunteers

Code: NCT07771517

Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms

for Depression

2 sites incl. Syracuse

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07202325

Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)

for Knee Osteoarthritis

1 site in Baltimore

Sponsor: VA Office of Research and Development

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT07649291·Phase 2

Community Health Worker Implementation of Transdiagnostic Evidence-based Mental Health Intervention for Spanish-speaking Latine Parents

for Depression

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07390630

Benefits of Exergames on Neurocognitive Functions in Adults Suffering From Depression

for Depression

Sponsor: MAP Institute

Sex: All·Age: 18 - 65

Code: NCT06536530

Personalizing Mental Health Treatment for Youth and Families

for Anxiety

Sponsor: University of Oregon

Sex: All·Age: 5 - 15

Code: NCT07425366

Group PACBT for Depression

for Depression - Major Depressive Disorder

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 21 - 60

Code: NCT07566104·Phase 2

Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health.

for Hepatitis B

Sponsor: Eunice Dube

Sex: All·Age: 13 - 50·Accepts healthy volunteers

Code: NCT06786429·Phase 4

A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients

for Major Depressive Disorder

1 site in Los Angeles

Sponsor: BioLite, Inc.

Sex: All·Age: 21 - 85

Code: NCT03833206·Phase 1, Phase 2

Multimodal Differences in Effort-based Decision-Making in Depression

for Depression

1 site in Atlanta

Sponsor: Georgia Institute of Technology

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06648460

Brain Network Mechanisms of Cognitive Impairments in Major Psychiatric Disorders and Their Clinical Applications

for Schizophrenia

Sponsor: Central South University

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07444463

Qualitative Study of Student Financial Insecurity and Psychiatry

for Depressive Disorder

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07719816

Accelerated iTBS for Depression and Suicidality

for Major Depressive Disorder

Sponsor: University of Iowa

Sex: All·Age: 18 - 90

Code: NCT04441008

Sham-Controlled Rapid-Acting Neuromodulation for Depression

for Depression - Major Depressive Disorder

1 site in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18 - 65

Code: NCT07487454

Electrophysiologic Mechanisms of Ketamine Antidepressant Response

for Epilepsy

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT07768618·Phase 2

Feasibility, Acceptability, and Preliminary Effectiveness of Cognitive Behavioral Therapy for Depression in Autistic Youth in Clinical Settings

for Autism Spectrum Disorder

1 site in Los Angeles

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 11 - 17

Code: NCT07755137

Ecological Momentary Assessment of State-Dependent Decision-Making and Metacognition Across a Psychopathology Continuum

for Depression

1 site in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 55

Code: NCT07801079

Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)

for Dementia (Diagnosis)

Sponsor: Zealand University Hospital

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT07200739

Treatment of Depression Post-SCI

for Depression

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 70

Code: NCT04263285

Apply to this trial

Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder

for Alcohol Use Disorder (AUD)

2 sites incl. Dallas

Sponsor: Sherwood Brown, MD, PhD

Sex: All·Age: 21 - 55

Code: NCT07734701·Phase 2

CODEPAD-III (Collaborative Outcomes of DEpression and Pain Associated With Delivery-III)

for Depression

Sponsor: KK Women's and Children's Hospital

Sex: All·Age: 21+

Code: NCT07773259

Prescribing the Right Agent for Depression in Adults (PRADA): a Double-blind, Randomised Controlled Trial Using a Web-based Multi-modal Clinical Decision Support System and Genetic Information to Personalise Antidepressant Treatment in Diverse Clinical Settings Across the Globe

for Major Depressive Disorder (MDD)

Sponsor: University of Oxford

Sex: All·Age: 18 - 74

Code: NCT07796295

Adult ADHD Symptoms, Depression, Anxiety, and Academic Performance in Medical Students

for Attention Deficit Hyperactivity Disorder

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07803224

A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder

for Major Depressive Disorder

20 sites incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT07772531·Phase 2

Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial

for Major Depressive Disorder (MDD)

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 22 - 80

Code: NCT07043738

Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts

for Major Depressive Disorder (MDD)

1 site in New York

Sponsor: New York State Psychiatric Institute

Sex: All·Age: 18 - 59

Code: NCT07139106·Phase 4

Task-Shifting Adapted IPT-A for Youth Suicide Prevention

for Suicidal Ideation

1 site in Chestnut Hill

Sponsor: Boston College

Sex: All·Age: 12 - 17

Code: NCT07383831

Teen Vulnerability to Irritability: Brain and Estrogen Changes

for Depression - Major Depressive Disorder

2 sites in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 12 - 16·Accepts healthy volunteers

Code: NCT07544966·Phase 4

Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression

for Major Depressive Disorder (MDD)

Sponsor: First Affiliated Hospital of Chongqing Medical University

Sex: All·Age: 12 - 18

Code: NCT07645157·Phase 2

Apply to this trial

Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents

for Major Depressive Disorder (MDD)

Sponsor: Massachusetts General Hospital

Sex: All·Age: 8 - 17

Code: NCT07793071·Phase 2

The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study

for Depression

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT06206226

Apply to this trial

Efficacy of EMONO as an add-on Therapy to Conventional Antidepressants for the Treatment of Depressive Symptoms in Nursing-home Residents With Neurocognitive Disorders: a Randomized Controlled Trial-

for Depression

Sponsor: University Hospital, Tours

Sex: All·Age: 60+

Code: NCT06382389·Phase 2

Sedation and Guided Education for Depression Study

for Major Depressive Disorder (MDD)

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06705270

Deaf CBT-TS to Reduce Suicide Risk

for Depression - Major Depressive Disorder

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT07279363

Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder

for Depression - Major Depressive Disorder

1 site in Durham

Sponsor: Pulvinar Neuro, LLC

Sex: All·Age: 22+

Code: NCT07282678

An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies.

for Pharmacogenetics

1 site in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT07373470

Apply to this trial

JAK Signaling in Depression and Cognition in Male Football Players

for Depressive Symptoms

3 sites in Atlanta

Sponsor: Emory University

Sex: Male·Age: 30 - 55·Accepts healthy volunteers

Code: NCT07608796·Phase 2

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

for Fibromyalgia

Sponsor: Hospital Ambroise Paré Paris

Sex: All·Age: 18 - 80

Code: NCT07642882

Apply to this trial

Pregnenolone for Cannabis Use Disorder and Depression

for Cannabis Use Disorder

2 sites incl. Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 50

Code: NCT07685964·Phase 1, Phase 2

Cognitive Stimulation Program With Virtual Reality for Older Adults With Depressive Symptoms

for Depressive Symptoms

Sponsor: Grupo Lusófona

Sex: All·Age: 65+

Code: NCT07710222

Evaluating the Impact of Digital Behavioral Interventions to Address Insomnia and Depression in Breast Cancer Survivors Using an Adaptive Design

for Insomnia

1 site in Charlottesville

Sponsor: University of Virginia

Sex: Female·Age: 18+

Code: NCT07721064

Context-Guided Personalized iTBS for Depression

for Major Depressive Disorder (MDD)

Sponsor: Capital Medical University

Sex: All·Age: 18 - 55

Code: NCT07743398

Supported Online Self-Help for Veterans With Depression in Primary Care

for Depression

2 sites incl. San Diego

Sponsor: University of California, Los Angeles

Sex: All·Age: 18+

Code: NCT07781228

REWIRE: Real-world Engagement With Interventional and Rejoyn Effectiveness

for Major Depressive Disorder (MDD)

2 sites incl. Greenwich

Sponsor: Yale University

Sex: All·Age: 22+

Code: NCT07792252

Virtual Group Therapy for IBD Patients With Anxiety and Depression

for Crohn's Disease (CD)

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07796568

Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression

for Treatment Resistant Depression

Sponsor: The Royal's Institute of Mental Health Research

Sex: All·Age: 18 - 65

Code: NCT07801703·Phase 2, Phase 3

Study of Lurasidone as Adjunctive Treatment in Patients With Major Depressive Disorder With Inadequate Response to Antidepressant Monotherapy

for Major Depressive Disorder (MDD)

Sponsor: Bukwang Pharmaceutical

Sex: All·Age: 19 - 64

Code: NCT07781293·Phase 3

Evaluating Conversational Artificial Intelligence for Depression Management

for Major Depressive Disorder (MDD)

1 site in Fairfax

Sponsor: George Mason University

Sex: All·Age: 18 - 85

Code: NCT07105397

Apply to this trial

Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome

for Depression

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07469176

Study on Mental Health Promoting Effects of Natural Psychotherapy for Adolescents

for Anxiety Disorders

Sponsor: Beijing HuiLongGuan Hospital

Sex: All·Age: 7 - 18·Accepts healthy volunteers

Code: NCT07639476

New trials in Boston, MA?

Pick a condition and we'll email you once a week when a new study starts recruiting in Boston, MA. Unsubscribe anytime.

Depression clinical trials — common questions

Are depression clinical trials free to join?

Yes. Participating in a depression clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a depression clinical trial?

Each depression study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a depression trial near me?

Use the location controls above. We'll show recruiting depression trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many depression trials are recruiting right now?

We're currently tracking roughly 680 recruiting depression trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Depression trials by city

Boston, MA Los Angeles, CA Chicago, IL San Diego, CA Ann Arbor, MI San Francisco, CA Birmingham, AL Madison, WI Stanford, CA Miami, FL Palo Alto, CA Aurora, CO

Related specialties

Psychiatry Mental health Behavioral health