Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation

Sponsor
Sungkyunkwan University
Study ID
NCT07156955
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
19 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Electrical stimulation cue — BEHAVIORAL
    A single 30-minute session is provided. Electrodes are attached to the cubital fossa, and stimulation is delivered at a frequency that increases up to 70 Hz as the elbow joint approaches the target angle. Target angles are set between 0 degrees and 120 degrees, based on each participant's available range of motion determined during the initial assessment. Participants adjust their elbow joint angle to match the provided target angle using feedback from the electrical stimulation. When the elbow joint angle matches the target angle, the maximum frequency is applied to the cubital fossa. Participants match their elbow joint angle to the target angle based on the given frequency.
  • Visual stimulation cue — BEHAVIORAL
    A single 30-minute session is provided. The difference between the current elbow joint angle and the pre-set target angle is displayed on a screen using two colored needles (a red needle for the target angle and a black needle for the current elbow joint angle). The target angle is set within each participant's available range of motion based on the initial assessment. Participants continue the intervention by adjusting their elbow angle using the visual feedback. When the elbow joint angle matches the target angle, the two needles overlap. Based on this visual cue, participants adjust their elbow joint angle to match the target angle.
  • No cue — BEHAVIORAL
    A single 30-minute session is provided. The target angle is determined within each participant's available range of motion based on the initial assessment. Throughout the session, participants receive verbal feedback from the assessor and adjust their elbow joint angle accordingly to match the target angle.

Study Details

The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients. The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.

Key Dates

First listed
Sep 5, 2025
Start date
Sep 1, 2026
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Mar 30, 2027

Study Design

Enrollment
3 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Electrical stimulation cue first
    Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order Electrical stimulation cue, Visual cue, and No cue or Electrical stimulation cue, No cue, and Visual cue.
  • Experimental: Visual stimulation cue first
    Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: Visual cue, Electrical stimulation cue, and No cue, or Visual cue, No cue, and Electrical stimulation cue.
  • Experimental: No cue first
    Patients undergo three types of interventions, following one of two processes. Each process has its own protocol in the following order: No cue, Electrical stimulation cue, and Visual cue, or No cue, Visual cue, and Electrical stimulation cue.
  • Experimental: Only electrical stimulation cue
    Patients undergo one types of interventions which is the Electrical stimulation cue.
  • Experimental: Only visual stimulation cue
    Patients undergo one types of interventions which is the Visual stimulation cue.
  • Experimental: Only no cue
    Patients undergo one types of interventions which is the No cue.

Primary Outcome Measure

Improvement in upper limb motor function [ Time Frame: 6 visits over 3 weeks ]

Central Contacts

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