Mass Spectrometry-based Immune Profiling in Autoimmune Diseases

Conditions

• Ankylosing Spondylitis
• Gouty Arthritis (GA)
• Healthy Controls
• Inflammatory Myopathies
• Osteoarthritis
• Psoriatic Arthritis (PsA)
• Rheumatoid Arthritis (RA)
• Sjogren's Syndrome
• Systemic Lupus Erthematosus
• Systemic Sclerosis (SSc)
• Vasculitis

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Study Details

Based on mass spectrometry flow method, this study analyzed the typing of new T, B, NK and DC cell subsets in peripheral blood of common autoimmune diseases and their correlation with disease activity, aiming at establishing an early screening and diagnosis model of autoimmune diseases.

Key Dates

First listed

Sep 23, 2025

Start date

May 25, 2025

Status verified

Aug 2026

Primary completion

Sep 30, 2026

Completion

Sep 30, 2026

Study Design

Enrollment

500 participants (estimated)

Arms

• Arm: The patients with active autoimmune diseases
  The study will include patients with systemic lupus erythematosus, Sjogren's syndrome, inflammatory myopathy, systemic sclerosis, vasculitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis and gouty arthritis and healthy controls. About 50 patients of each type are required. The patients are in a state of disease activity and do not use biological agents.

Primary Outcome Measure

proportion of immune cell subsets in peripheral blood. [ Time Frame: through study completion, an average of 1 year ]

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