Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control

Conditions

• Hypertension
• Primary Care

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Not accepted

Interventions

• Provider nudge — BEHAVIORAL
  Pharmacists will deliver targeted nudges to providers through clinical decision support integrated into the electronic health record (EHR)
• Patient nudge — BEHAVIORAL
  Patients will receive pharmacist-delivered nudges (e.g., text messages) 1-7 days before their visit to encourage fixed-dosed combinations
• Pharmacist Virtual Visit — BEHAVIORAL
  Patients will receive pharmacist counseling and prescribing delivered via virtual encounters after their visit

Study Details

The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use. The trial will test the effectiveness of theory-driven nudges tailored to address provider and patient barriers. All interventions will be pharmacist-driven, with pharmacists delivering information via nudges to providers and via nudges or more intensive interventions (i.e., CPA) to patients. Data to evaluate outcomes will be extracted from electronic health records.

Key Dates

First listed

Nov 13, 2025

Start date

Aug 7, 2026

Status verified

Aug 2026

Primary completion

Apr 30, 2027

Completion

Jun 30, 2027

Study Design

Enrollment

720 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Arms

• Active Comparator: Provider nudge only
  Pharmacists will deliver targeted nudges to providers through clinical decision support integrated into the EHR.
• Experimental: Provider nudge + Patient nudge
  In addition to provider nudges (Provider nudge only arm), patients will receive pharmacist delivered nudges (e.g., text messages) 1-7 days before the visit to encourage fixed dose combination medications.
• Experimental: Provider nudge + Pharmacist Virtual Visit
  In addition to provider nudges (Provider nudge only arm), patients will receive pharmacist counseling and prescribing delivered via virtual encounters after the visit.

Primary Outcome Measure

Change in systolic blood pressure [ Time Frame: 6 months ]

Locations (1)

Find similar trials in Milwaukee, WI

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