High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients

Sponsor
Zhejiang University
Study ID
NCT07307560
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • High-flow nasal cannula Group — DEVICE
    Using High-flow nasal cannula oxygenation
  • Regular Nasal Cannula — DEVICE
    Using regular nasal cannula for oxygenation

Study Details

Hypoxia represents the most frequent adverse event during propofol-sedated gastrointestinal endoscopy. The STOP-BANG questionnaire serves as a widely adopted, straightforward tool for screening obstructive sleep apnea (OSA) risk, with a score ≥5 identifying high-risk OSA patients who are particularly susceptible to hypoxia under sedation. Although preliminary research from our team suggests that High-Flow Nasal Cannula (HFNC) may lower the incidence of hypoxemia, evidence remains limited and inconsistent in studies specifically targeting high-risk OSA populations. Therefore, this multicenter randomized controlled trial aims to evaluate whether HFNC can effectively reduce the occurrence of hypoxia during sedated gastrointestinal endoscopy in patients identified as high-risk for OSA.

Key Dates

First listed
Dec 29, 2025
Start date
Dec 21, 2025
Status verified
Dec 2025
Primary completion
Dec 1, 2026
Completion
Dec 1, 2026

Study Design

Enrollment
600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: High-flow nasal cannula Group
    In this group, patients use the High-flow nasal cannula
  • Active Comparator: Regular Nasal Cannula Group
    In this group, patients use the regular nasal cannula for oxygenation.

Primary Outcome Measure

The incidence of hypoxia [ Time Frame: Patients will be followed for the duration of hospital stay, an expected average about 2 hours ]

Central Contacts

Find similar trials

Nationwide
Esophageal cancer trialsOncology trialsGI oncology trials

Related Studies