Esophageal cancer Clinical Trials

Recruiting esophageal cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat esophageal cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting esophageal cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting esophageal cancer trials

Within

Outside the Cage (OTC) Robotic Esophagectomy

for Esophageal Cancer

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 18+

Code: NCT06735638·Phase 1

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07206589

Evaluation of the Administration of Artificial Nutrition by Feeding Jejunostomy During Neoadjuvant Treatment on Postoperative Morbidity in the Context of Esophageal or Stomach Cancer

for Esophageal Cancer

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT07584577

Apply to this trial

Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function

for Esophageal Cancer

Sponsor: Sunshine Lake Pharma Co., Ltd.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05048368·Phase 1

Neoadjuvant Intra-tumoral RP2 and FLOT in Gastroesophageal Adenocarcinoma

for Gastric Adenocarcinoma

1 site in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07059611·Phase 2

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

for Esophageal Adenocarcinoma

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07603375·Phase 2

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or Chemotherapy in Adults With Metastatic Gastric, Gastroesophageal Junction (GEJ), and Esophageal Adenocarcinomas

for HER2-negative

1 site in Boston

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT07546812·Phase 2

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Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease

for Chest Wall Tumor

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07685938·Phase 2

SL-28 for Advanced Solid Tumours

for Head & Neck Cancer

Sponsor: Second Life Therapeutics

Sex: All·Age: 18+

Code: NCT07341737·Phase 1, Phase 2

Apply to this trial

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

for Barrett Esophagus

6 sites incl. Kansas City

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06732388·Phase 2

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Prehabilitation in High-risk Oncologic Surgery

for Pancreatic Cancer

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT07638410

Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma

for Esophageal Adenocarcinoma

1 site in Weston

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07222657·Phase 2

Apply to this trial

Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels

for Foregut Adenocarcinoma

1 site in New Haven

Sponsor: Yale University

Sex: All·Age: 18 - 80

Code: NCT07282912·Phase 2

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The Value of Near-Infrared Fluorescence Imaging in the Protection of the Recurrent Laryngeal Nerve During Minimally Invasive Esophagectomy

for Esophageal Cancer

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18 - 75

Code: NCT07406815·Phase 3

ProofPrincip IntraTu TCells SinglDoseImmunCheckpoinInhib Gastro-Esophage Adenocarcinoma w/ARID1a Mu

for Solid Tumor, Adult

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT06824363·EARLY_Phase 1

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A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

for Colorectal Cancer

2 sites incl. Sarasota

Sponsor: Immunome, Inc.

Sex: All·Age: 18+

Code: NCT07578571·Phase 1

Apply to this trial

Exercise Training After Upper Gastrointestinal Cancer Surgery

for Esophageal Cancer

Sponsor: Kansai Medical University

Sex: All·Age: 18+

Code: NCT07561840

Apply to this trial

Large-scale Models of Esophageal Cancer and Related Research

for Esophageal Cancer

Sponsor: The First Affiliated Hospital of Henan University of Science and Technology

Sex: All·Age: 18 - 90

Code: NCT07642401

Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma

61 sites incl. Los Angeles

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07392892·Phase 2, Phase 3

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Circulating Tumor DNA MRD-Guided Adjuvant Therapy for Curatively Resected Locally Advanced Esophageal Squamous Cell Carcinoma

for Esophageal Cancer

Sponsor: Asan Medical Center

Sex: All·Age: 19+

Code: NCT06914011·Phase 3

A Prospective Study of Tumor-specific Tpex in Negative Lymph Nodes for Predicting Pathological Complete Response to Neoadjuvant PD 1 Therapy in Esophageal Cancer

for Esophageal Cancer

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT07573397

The Application of Symptoms Management Program Based on the Patient Reported Outcome After Esophagectomy

for Esophageal Cancer

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18+

Code: NCT07187154

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PAravertebral CaTheter Versus Epidural Analgesia in Totally Minimally Invasive Esophagectomies

for Esophageal Cancer

Sponsor: University Hospital, Lille

Sex: All·Age: 18+

Code: NCT07434739

A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers

for Colorectal Cancer

3 sites incl. Duarte

Sponsor: Dispatch Biotherapeutics

Sex: All·Age: 18+

Code: NCT07544589·Phase 1

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Timing of Minimally Invasive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma

for Esophageal Cancer

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: 18+

Code: NCT07000253·Phase 2, Phase 3

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Tpex Subsets in Negative Tumor Draining Lymph Nodes for Predicting the Efficacy of PD 1 Inhibitors in Advanced or Recurrent Esophageal Squamous Cell Carcinoma

for Esophageal Cancer

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT07533357

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for Non-Small-Cell Lung

4 sites incl. Denver

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07519655·Phase 1

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Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers

for Gastric Cancer

Sponsor: Blokhin's Russian Cancer Research Center

Sex: All·Age: 18+

Code: NCT07464470

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Stereotactic Body Radiation Therapy (SBRT) and Immunotherapy for Oligometastatic Esophageal Cancer

for Esophageal Cancer

Sponsor: AHS Cancer Control Alberta

Sex: All·Age: 18+

Code: NCT07330583·Phase 2

Clinical Trial Evaluating TQB6411 Injection in Participant s With Esophageal Cancer

for Esophageal Cancer

Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07367516·Phase 1, Phase 2

Apply to this trial

Distance-Based Exercise to Preserve Function and Prevent Disability

for Localized Malignant Solid Neoplasm

18 sites incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884

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Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for Solid Tumor

3 sites incl. Goodyear

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT07432295·Phase 2

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Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2

for Gastric Cancer

72 sites incl. Mobile

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07431281·Phase 3

Apply to this trial

Clinical Trial Protocol for Evaluating the Efficacy and Safety of Thoracoabdominal Endoscopic Surgery System in Remote Laparoscopic Surgery for Urology, General Surgery, Gynecology and Thoracic Surgery

for Colorectal Cancer

Sponsor: Cornerstone Robotics

Sex: All·Age: 18 - 80

Code: NCT07382635

EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors

for Cancer

Sponsor: Essen Biotech

Sex: All·Age: All ages

Code: NCT07410676·Phase 1, Phase 2

Apply to this trial

Application of Toripalimab as Adjuvant Therapy After Esophageal Cancer Surgery: A Multicenter Clinical Trial

for Esophageal Cancer

Sponsor: Henan Cancer Hospital

Sex: All·Age: 18 - 75

Code: NCT07332221·Phase 3

The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy

for Esophageal Cancer

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18 - 75

Code: NCT07303231·Phase 3

Indocyanine Green-guided Omental Shield Anastomosis for Cervical Esophagogastric Anastomosis in Minimally Invasive McKeown Esophagectomy

for Esophageal Squamous Cell Carcinoma (ESCC)

Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

Sex: All·Age: 18 - 80

Code: NCT07376876·Phase 2

QL1706 Plus Chemotherapy for Borderline Resectable Esophageal Cancer

for Esophageal Cancer

Sponsor: Ruijin Hospital

Sex: All·Age: 18+

Code: NCT07283991·Phase 2

High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients

for Hypoxia

Sponsor: Zhejiang University

Sex: All·Age: 18+

Code: NCT07307560

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Based on ctDNA-MRD Guided Adjuvant Treatment Escalation After Definitive Chemoradiotherapy for Unresectable Locally Advanced Esophageal Squamous Cell Carcinoma: a Study on Safety and Efficacy

for Esophageal Cancer

Sponsor: The First Affiliated Hospital with Nanjing Medical University

Sex: All·Age: 18 - 80

Code: NCT07371247·EARLY_Phase 1

Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer Using Durvalumab-680LT and Nivolumab-800CW

for Esophageal Cancer

Sponsor: University Medical Center Groningen

Sex: All·Age: 18+

Code: NCT07196384·Phase 1

A Phase Ib Trial Evaluating the Safety and Activity of Neoadjuvant Combination of Tislelizumab Plus FLOT for Resectable Esophagogastric Adenocarcinoma

for Esophagogastric Junction Adenocarcinoma

Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Sex: All·Age: 18+

Code: NCT07059299·Phase 1

Apply to this trial

ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients

for Esophageal Cancer

Sponsor: National Taiwan University Hospital

Sex: Male·Age: 18 - 99

Code: NCT07322627

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A Multiple Tumor Species, Open and Multi-center Clinical Study of Alpaloritovorelli Antibodies (QL-1706) Combined with Pulsed Low Dose Rate External Irradiation (PLDR) for Disease Progression After Previous Anti-tumor Therapy

for Esophageal Cancer

Sponsor: Anhui Provincial Hospital

Sex: All·Age: 18 - 75

Code: NCT06760676·Phase 1

Development and Application of AI-Based Therapeutic Strategies for Esophageal Cancer Integrating Multimodal Imaging and Digital Pathology

for Esophageal Cancer

Sponsor: Henan Cancer Hospital

Sex: All·Age: 18+

Code: NCT07203690

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for Esophageal Squamous Cell Carcinoma

10 sites incl. Scottsdale

Sponsor: Plexium, Inc.

Sex: All·Age: 18+

Code: NCT07284186·Phase 1

Apply to this trial

Minimally Invasive Molecular Approaches for the Detection of Barrett's Esophagus- High Grade Dysplasia and Esophageal Adenocarcinoma

for Barrett Esophagus

3 sites incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07212491

Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.

for Esophageal Cancer

15 sites incl. Cerritos

Sponsor: SOFIE

Sex: All·Age: 18+

Code: NCT07217704·Phase 3

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A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

for Head and Neck Squamous Cell Carcinoma HNSCC

6 sites incl. Denver

Sponsor: Sutro Biopharma, Inc.

Sex: All·Age: 18+

Code: NCT07227168·Phase 1

Apply to this trial

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

for Renal Cell Carcinoma

1 site in Pittsburgh

Sponsor: Diwakar Davar

Sex: All·Age: 18+

Code: NCT07223424·Phase 2

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DCRT vs. Surgery in Resectable ESCC Patient Achiving cCR/PR After nCI

for Esophageal Cancer

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: All·Age: 18 - 75

Code: NCT07162506·Phase 2

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A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

for HNSCC

9 sites incl. Denver

Sponsor: Normunity AccelCo, Inc.

Sex: All·Age: 18+

Code: NCT07182149·Phase 1

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Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbidly Obese Patients

for Hypoxemia

Sponsor: Zhejiang University

Sex: All·Age: 18+

Code: NCT07175155

Apply to this trial

Brachytherapy With Radiotherapy and Immunotherapy: Guided HDR Trial in Esophageal Squamous Cell Carcinoma

for Esophageal Cancer

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18 - 85

Code: NCT07152678·Phase 2

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Low-Dose Radiotherapy in Patients With Advanced Esophageal Squamous Cell Carcinoma Resistant to First-Line Chemotherapy Combined With Immunotherapy

for Esophageal Adenocarcinoma

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT07164690·Phase 2

DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

18 sites incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000

Apply to this trial

Total Neoadjuvant Therapy for Lymph Node-positive Adenocarcinoma of the OESophagus and Oesophagogastric Junction

for Esophageal Cancer

Sponsor: Erasmus Medical Center

Sex: All·Age: 18+

Code: NCT06161818·Phase 2

Apply to this trial

CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors

for Lung Cancer

Sponsor: Chongqing Precision Biotech Co., Ltd

Sex: All·Age: 18+

Code: NCT07179692·Phase 1

Apply to this trial

Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC

for Esophageal Cancer

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT07177794·Phase 3

Apply to this trial

Esophageal cancer clinical trials — common questions

Are esophageal cancer clinical trials free to join?

Yes. Participating in a esophageal cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a esophageal cancer clinical trial?

Each esophageal cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a esophageal cancer trial near me?

Use the location controls above. We'll show recruiting esophageal cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many esophageal cancer trials are recruiting right now?

We're currently tracking roughly 101 recruiting esophageal cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Esophageal cancer trials by city

Boston, MA Duarte, CA Denver, CO Los Angeles, CA Aurora, CO Beverly Hills, CA Birmingham, AL Orange, CA San Diego, CA Ann Arbor, MI Cleveland, OH

Related specialties

Oncology GI oncology