Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia

Conditions

• Knee Stiffness After Total Knee Arthroplasty

Eligibility Criteria

Sex

ALL

Age

18 Years - 75 Years

Healthy Volunteers

Not accepted

Interventions

• Spinal Anesthesia — PROCEDURE
  Administration of spinal anesthesia for knee manipulation.
• General Anesthesia — PROCEDURE
  Administration of general anesthesia for knee manipulation.
• Propofol — DRUG
  Patients undergoing general anesthesia will receive an induction dose of propofol that will be titrated to effect, and airway support as needed until the patient is appropriately anesthetized for the procedure as determined by the anesthesia and surgical care teams.
• Chloroprocaine — DRUG
  Patients undergoing spinal anesthesia will receive a spinal injection under standard aseptic technique, with 45mg chloroprocaine.

Study Details

The purpose of this study is to determine if changing the type of anesthesia improves the outcomes of manipulation and pain control after the procedure. The study will compare a spinal anesthesia with a general anesthesia, to see if there is a better outcome from either anesthesia type.

Key Dates

Start date

Jun 1, 2026

Status verified

Jan 2026

Primary completion

Aug 31, 2027

Completion

Sep 30, 2027

Study Design

Enrollment

128 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Spinal Anesthesia
  Patients receive spinal anesthesia during MUA (manipulation under anesthesia).
• Active Comparator: General Anesthesia
  Patients receive general anesthesia during MUA (manipulation under anesthesia).

Primary Outcome Measure

Change in degrees of motion of the affected knee [ Time Frame: At time of procedure completion ]

Locations (1)

Find similar trials in Durham, NC