Clinical, Microbial and Tissue-based Characterization of Patients Treated for Severe Temporomandibular Joint Pathology

Sponsor
Örebro University, Sweden
Study ID
NCT07350239
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • open TMJ surgery such as arthroplasty surgery with or without autogen or allogen reconstruction — PROCEDURE
    Consecutive patients (n=20) were offered open TMJ surgery, such as arthroplasty surgery with or without autogenous or allogenic reconstruction, due to TMJ ankylosis or severe osteoarthritis. The patients were treated at Karolinska University Hospital, Örebro University Hospital, or Lund University Hospital.

Study Details

The general objective of this observational study is to clarify the clinical, microbial, and tissue characteristics, aetiology, and risk factors behind severe TMJ pathology. The main questions it aims to answer are: * What are the clinical and histologic characteristics of patients with severe pathology of the TMJ? * Can microbial DNA be found in TMJ tissue from patients with severe pathology of the TMJ, and if so, does this correlate to the outcome of the surgery?

Key Dates

First listed
Jan 20, 2026
Start date
Mar 1, 2026
Status verified
Jan 2026
Primary completion
Nov 1, 2028
Completion
Feb 1, 2029

Study Design

Enrollment
20 participants (estimated)

Arms

  • Arm: Patients with TMJ ankylosis or severe osteoarthritis of TMJ.

Primary Outcome Measure

Clinical investigation (patients): [ Time Frame: Inclusion will take at least 3 years, followed by one year of follow-up ]

Central Contacts

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