Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors

Sponsor
Medical University of Warsaw
Study ID
NCT07411690
Status
Recruiting
Apply to this trial

Conditions

  • Brain Tumor Adult
  • Brain Tumor Benign
  • CerebroSpinal Fluid (CSF) Leak
  • Craniotomy
  • Glioblastoma
  • Glioma
  • Meningioma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

Cerebrospinal fluid is a clear fluid that surrounds and protects the brain. During surgery for brain tumors, neurosurgeons often need to open the covering of the brain (the dura) to reach the tumor. At the end of the operation, this covering is carefully closed again. In some cases, the closure might not be completely adequate leading to cerebrospinal fluid leak. This leakage may collect under the scalp or flow out through the surgical wound. When this happens, the surgical wound may not heal properly, and the risk of infection can increase. These complications can delay recovery and may postpone additional treatments, such as radiotherapy or chemotherapy, that are often needed after brain tumor surgery. Although cerebrospinal fluid leakage is less common after supratentorial craniotomy (surgery on the upper part of the brain) than after other types of brain surgery, it remains a challenging complication and has not been well studied in this group of patients. The aim of this study is to determine how often cerebrospinal fluid leakage occurs after supratentorial craniotomy for intracranial tumors, identify factors that increase the risk of leakage, and evaluate how these leaks are managed. Understanding these factors may help reduce the occurrence of cerebrospinal fluid leakage and improve postoperative recovery in the future.

Key Dates

First listed
Feb 17, 2026
Start date
Feb 3, 2026
Status verified
Feb 2026
Primary completion
Feb 29, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Patients qualified for a supratentorial craniotomy for intracranial tumor
    Patients who are qualified for a supratentorial craniotomy for intracranial tumor who need neither urgent neurosurgical treatment or secondary surgery due to tumor progression.

Primary Outcome Measure

Cerebrospinal fluid leakage occurrence. [ Time Frame: From the enrollment till the end of observation period (6 weeks postoperatively) ]

Central Contacts

Find similar trials

Nationwide
Brain cancer trialsOncology trialsNeuro-oncology trials

Related Studies