The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension

Sponsor
Johns Hopkins University
Study ID
NCT07460882
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Low-sodium salt substitute — DIETARY_SUPPLEMENT
    The low sodium salt substitute contains 25% potassium chloride (KCl range; 20%-35%)

Study Details

The goal of this pre-post study is to assess the risk of hyperkalemia in adults with hypertension on medication in Bangladesh. The main questions it aims to answer are: Is the risk of hyperkalemia after the initiation of Low Sodium Salt Substitute (LSSS) in people on antihypertensive medication (especially RASi) large enough to be concerned about its broad use in this population? Does initiation of LSSS correct hypokalemia in people on antihypertensive medication (especially RASi) with low serum potassium levels? Participants will be asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt.

Key Dates

First listed
Mar 10, 2026
Start date
Aug 15, 2026
Status verified
Jul 2026
Primary completion
Mar 31, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
607 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Low sodium salt substitute (LSSS)
    Participants are asked to reduce overall salt intake and to use LSSS on every occasion where regular salt would normally be used, including as cooking salt

Primary Outcome Measure

Incident hyperkalemia (K ≥5.5 mmol/L) [ Time Frame: 4 and 8 weeks ]

Central Contacts

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