Assessing the Effectiveness of Low-Dose Computed Tomography in Lung Cancer Screening for High-Risk Smokers: A Randomized Controlled Trial in Hong Kong

Sponsor
The University of Hong Kong
Study ID
NCT07478757
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - 79 Years
Healthy Volunteers
Accepted

Interventions

  • Low-dose computed tomography (LDCT) — DIAGNOSTIC_TEST
    3 rounds of LDCT screening performed at the baseline (T0), 18 ± 3 months (T1), 42 ± 3 months (T2) from baseline

Study Details

The investigators propose a randomized controlled trial to evaluate the clinical effectiveness of low-dose computed tomography (LDCT) for lung cancer screening in high-risk Chinese ever-smokers aged 50-79 years in Hong Kong and to assess the cost-effectiveness of implementing LDCT for lung cancer screening in the local setting.

Key Dates

First listed
Mar 17, 2026
Start date
Jul 1, 2026
Status verified
Mar 2026
Primary completion
Jun 30, 2032
Completion
Jun 30, 2037

Study Design

Enrollment
15,000 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING

Arms

  • Active Comparator: SCREEN Arm
    SCREEN Arm: 3 rounds of LDCT screening performed at the baseline (T0), 18 ± 3 months (T1), 42 ± 3 months (T2) from baseline
  • No Intervention: CONTROL arm
    CONTROL arm: No LDCT screening

Primary Outcome Measure

Lung cancer mortality [ Time Frame: 10 years ]

Central Contacts

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