Methadone in the Management of Post-Operative Pain in Total Knee Replacement

Part of paid clinical trials in Denver, Colorado.

Sponsor
AdventHealth
Study ID
NCT07485803
Phase
PHASE4
Status
Recruiting
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Conditions

  • Total Knee Arthroplasty

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Methadone — DRUG
    Subjects randomized to receive methadone will be given one dose of methadone 0.15mg/kg intravenously dosed based on ideal body weight administered by the anesthesia team prior to surgical incision

Study Details

The goal of this study is to determine whether one dose of IV methadone given right before surgery will help patients' pain management after a total knee replacement and reduce the amount of pain medications taken in the weeks after surgery.

Key Dates

Start date
Jun 1, 2026
Status verified
Mar 2026
Primary completion
Apr 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
192 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Methadone
    Patient will receive one perioperative dose of IV methadone prior to their surgical procedure in addition to standard of care medications.
  • No Intervention: No medication
    Patient will receive only the standard of care medications for their procedure.

Primary Outcome Measure

Opioid use for 48 hours post-operatively [ Time Frame: 48 hours after TKA procedure ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
AdventHealth PorterDenverColorado80210
Makenna Hemmerle
[email protected]
3032602951

Find similar trials in Denver, CO

By research site
AdventHealth Porter· Denver, CO

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