MRgFUS for Childhood Epilepsy

Sponsor
The Hospital for Sick Children
Study ID
NCT07497178
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
4 Years - 17 Years
Healthy Volunteers
Not accepted

Interventions

  • Ablation — PROCEDURE
    MRI-guided focused ultrasound ablation (MRgFUS) of central brain lesions in children with drug-resistant epilepsy.

Study Details

The goal of this observational study is to learn if magnetic resonance imaging guided focused ultrasound (MRgFUS) can treat brain lesions causing epilepsy in children with drug resistant epilepsy. The main questions it aims to answer are: Is MRgFUS safe in children with drug-resistant epilepsy due to central brain lesions? Does MRgFUS treatment reduce seizure frequency and severity and improve quality-of-life? Researchers will prospective assess outcomes following MRgFUS in children. Participants undergoing MRgFUS will complete seizure diaries and questionnaires related to seizure severity and quality-of-life.

Key Dates

First listed
Mar 27, 2026
Start date
Mar 1, 2026
Status verified
Jan 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Other: MRgFUS Treatment
    MRgFUS treatment of epileptogenic brain lesions

Primary Outcome Measure

Engel Epilepsy Surgery Outcome Score [ Time Frame: baseline, 7 days, 1 month, 6 months, 1 year ]

Central Contacts

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