Epilepsy Clinical Trials

Recruiting epilepsy studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat epilepsy. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting epilepsy studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting epilepsy trials

Within

Cholinergic Enhancement of Theta

for Epilepsy

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07228338·EARLY_Phase 1

Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome (LGS)

Sponsor: University of Minnesota

Sex: All·Age: 18 - 65

Code: NCT07568860

Neural Basis of Cognition

for Epilepsy

Sponsor: Duke University

Sex: All·Age: 12+

Code: NCT05132543

Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures

for Seizures

2 sites incl. Winston-Salem

Sponsor: Azurity Pharmaceuticals

Sex: All·Age: 1 Month - 17

Code: NCT06534502·Phase 4

Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy

for Epilepsy

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 6 - 65

Code: NCT07281222

Assessment of MRI-guided HIFU for Patients With Drug-resistant Focal Epilepsy

for Epilepsy

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07591350

Biomarker Targeted Stimulation for Epileptiform Events

for Epilepsy

Sponsor: Cadence Neuroscience

Sex: Male·Age: 7+

Code: NCT06424977

Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy

for Epilepsy

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 55

Code: NCT07599150

A Phase 2 Study of the Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy

for Tuberous Sclerosis Complex

Sponsor: Aeovian Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07680322·Phase 2

Neural Mechanisms for Stopping Ongoing Speech Production (Study 2)

for Epilepsy

1 site in Pittsburgh

Sponsor: Lingyun Zhao

Sex: All·Age: 8 - 26

Code: NCT07713706

Sleep, Music, And Research Trial 2.0

for Epilepsy in Children

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18 Months - 9

Code: NCT07696442

Epilepsy Enhanced Care

for Epilepsy

Sponsor: Ente Ospedaliero Cantonale, Bellinzona

Sex: All·Age: 18+

Code: NCT07709481

Korus: a Device to Prevent Sudden Unexpected Death in Epilepsy (SUDEP)

for Epilepsy

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06135285

Health Literacy Project

for Epilepsy

Sponsor: Duke University

Sex: All·Age: 12 - 18

Code: NCT06634901

Lily's Grace Temporal Interference

for Epilepsy

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 75

Code: NCT07520955

Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations

for Epilepsy

2 sites incl. Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 3 - 70

Code: NCT06898138

The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy

for Epilepsy

Sponsor: Xuanwu Hospital, Beijing

Sex: All·Age: 18 - 60

Code: NCT07095933·EARLY_Phase 1

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Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy

for Epilepsy (Treatment Refractory)

Sponsor: Kemal Tutkavul

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07716930

Cenobamate in the Intensive Care Unit

for Epilepsy

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06352723·EARLY_Phase 1

Diagnosing Epilepsy To EffeCT Change Long-Term Follow-Up

for Epilepsy

16 sites incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110454

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Epileptiform Potential of Fully Immersive Virtual Reality

for Epilepsy

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 13+

Code: NCT07451093

PREDiction of Different Variants of Sleep Stages for the Diagnosis Support of Chronic Insomnia and Epilepsy

for Chronic Insomnia

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 65

Code: NCT07547501

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

for Focal Seizure

5 sites incl. Bentonville

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT07594119·Phase 3

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Bone Management in Pregnancy Outcomes in Epilepsy

for Epilepsy

Sponsor: The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07651709

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Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1

for Focal Seizure

3 sites incl. Palmdale

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT07563881·Phase 3

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AI-Based Mobile Intervention on Medication Non-Adherence and Transition

for Epilepsy

2 sites in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 14 - 24

Code: NCT07445074

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A Phase I Clinical Trial of UX-GIP001 in the Treatment of Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy

for Epilepsy

Sponsor: Shanghai UniXell Biotechnology Co., Ltd

Sex: All·Age: 18 - 75

Code: NCT07572812·Phase 1

A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome

for Epilepsy

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07013331

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The Benefits of a Care Pathway Combining Remote Monitoring and Support From a Nurse After a Change in Anti-epileptic Treatment: a Pilot Study

for Epilepsy

Sponsor: University Hospital, Toulouse

Sex: All·Age: 18+

Code: NCT07507240

Epilepsy Emergency Department High Utilizer Program

for Epilepsy

1 site in Atlanta

Sponsor: Morehouse School of Medicine

Sex: Female·Age: 18+

Code: NCT07663240

S100B Protein: a Diagnostic Aid in Episodes of Transient Loss of Consciousness?

for Epilepsy

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07527754

TIS for Drug Resistant TLE

for Epilepsy

Sponsor: Xijing Hospital

Sex: All·Age: 18 - 65

Code: NCT07519018

Effect of Epilepsy and Antiepileptic Drug Therapy on Gastric Motility and Emptying With Point-Of-Care Gastric Ultrasound

for Epilepsy

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07421661

Healthy Aging in People With Epilepsy Program

for Epilepsy

1 site in Cleveland

Sponsor: Anny Reyes

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT06052605

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Bridging the Gap: Educating Patients on Social Determinants of Health to Improve Epilepsy Surgery Access and Outcomes

for Epilepsy

1 site in Cleveland

Sponsor: Anny Reyes

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07509190

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Evaluation of the Efficacy of Neurofeedback Technique Based on EEG Desynchronization in Epileptic Patients

for Epilepsy

Sponsor: Assistance Publique Hopitaux De Marseille

Sex: All·Age: 18 - 18·Accepts healthy volunteers

Code: NCT07356661

MRgFUS for Childhood Epilepsy

for Drug Resistant Epilepsy

Sponsor: The Hospital for Sick Children

Sex: All·Age: 4 - 17

Code: NCT07497178

Hippocampal Oscillations During Exploration

for Epilepsy

1 site in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07224191

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Impact of Canine Mediation Practice in Psychomotor Therapy on Improving the Quality of Life in Adult Epileptic Patients.

for Epilepsy

Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Sex: All·Age: 18+

Code: NCT06898749

Compassion Focussed Therapy Informed Psychoeducation and Loving Kindness Meditation for Young People With Epilepsy

for Epilepsy

Sponsor: University of Lincoln

Sex: All·Age: 12 - 17

Code: NCT07265362

Prevalence of ADHD in Children With Epilepsy

for ADHD

Sponsor: Assiut University

Sex: All·Age: 3 - 18

Code: NCT07205211

Impact of Epilepsy on the Brainstem Adenosine Pathway and Its Relation With Arousal and Respiratory Reactivity

for Epilepsy

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07249034

Predictors of Drug Resistant Epilepsy Among Pediatric Patients

for Epilepsy

Sponsor: Assiut University

Sex: All·Age: 1 - 18

Code: NCT07241754

Diagnosing Epilepsy To EffeCT Change

for Epilepsy

19 sites incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337

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Prophylactic Anti-Seizure Medication vs No Anti-Seizure Medication for Patients With Primary Motor Cortex Brain Metastases

for Seizures

1 site in Boston

Sponsor: Ayal A. Aizer, MD

Sex: All·Age: 18+

Code: NCT07130786·Phase 2

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LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome

for Down Syndrome

Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Sex: All·Age: 40+

Code: NCT07234695·Phase 3

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The Impact of Medical TV Drama in Improving Literacy on Neurocysticercosis

for Neurocysticercosis

Sponsor: Cephas Health Research Initiative Inc, Ibadan, Nigeria

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07208656

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

for Focal Epilepsy

7 sites incl. Boise

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 70

Code: NCT07219407·Phase 2

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Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents

for Epilepsy

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: Up to 15

Code: NCT05126914

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Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)

for Baker Gordon Syndrome

1 site in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: Up to 99·Accepts healthy volunteers

Code: NCT07329257

Apply to this trial

LIFUS For Neurological Disorders

for Parkinson's Disease (PD)

Sponsor: University Health Network, Toronto

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07417280

Apply to this trial

Phenotypic Exploration During Sensory Stimulation in an Acoustic Chamber

for Epilepsy

Sponsor: Centre Hospitalier St Anne

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07544563

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Clinical Profile And Outcomes Of Neonatal Convulsions In The Neonatal Intensive Care Unit At Assiut University Children's Hospital

for Neonatal Convulsions

Sponsor: Assiut University

Sex: All·Age: 1 Day - 30 Days

Code: NCT07274410

Transition From Pediatric to Adult Care in Epilepsy

for Epilepsy

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 15+

Code: NCT07592676

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National Survey on Physical and Sports Activity of Adults With Epilepsy

for Epilepsy

Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Sex: All·Age: All ages

Code: NCT07075380

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Exploratory Study of UX-GIP001 Cell Therapy in Adult Patients With Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy (MTLE)

for Epilepsy

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Sex: All·Age: 18 - 75

Code: NCT07244328·EARLY_Phase 1

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Epilepsy and Driving

for Epilepsy

Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07026591

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Prospective Evaluation of Probabilistic Predictions of Epileptic Seizure Risk Using the EPIDAY Tool

for Epilepsy

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 65

Code: NCT07068919

Subcortical Arousal in Perceptual Awareness

for Epilepsy

8 sites incl. New Haven

Sponsor: Yale University

Sex: All·Age: 13+

Code: NCT06934356

Apply to this trial

Levetiracetam Three Times Daily in Epilepsy

for Epilepsy

Sponsor: Waad Alkathiri

Sex: All·Age: 18+

Code: NCT07490769·Phase 3

Apply to this trial

Epilepsy clinical trials — common questions

Are epilepsy clinical trials free to join?

Yes. Participating in a epilepsy clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a epilepsy clinical trial?

Each epilepsy study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a epilepsy trial near me?

Use the location controls above. We'll show recruiting epilepsy trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many epilepsy trials are recruiting right now?

We're currently tracking roughly 108 recruiting epilepsy trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Epilepsy trials by city

Boston, MA San Francisco, CA Palo Alto, CA Cleveland, OH Birmingham, AL Jacksonville, FL Miami, FL Sacramento, CA Stanford, CA Worcester, MA Boise, ID Chicago, IL

Related specialties

Neurology Brain disorders